(S)-1-PHENYL-1,2,3,4-TRTROHYDROISOQUINOLINE
(1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline
CAS: 118864-75-8
Molecular Formula: C15H15N
(S)-1-PHENYL-1,2,3,4-TRTROHYDROISOQUINOLINE - Names and Identifiers
(S)-1-PHENYL-1,2,3,4-TRTROHYDROISOQUINOLINE - Physico-chemical Properties
| Molecular Formula | C15H15N |
| Molar Mass | 209.29 |
| Density | 1.065 |
| Melting Point | 80-82°C |
| Boling Point | 338°C |
| Flash Point | 167°C |
| Solubility | Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly) |
| Vapor Presure | 9.87E-05mmHg at 25°C |
| Appearance | White solid |
| Color | White to Off-White |
| pKa | 8.91±0.40(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Refractive Index | 1.589 |
| MDL | MFCD08692036 |
(S)-1-PHENYL-1,2,3,4-TRTROHYDROISOQUINOLINE - Reference Information
| Application | (S)-1-phenyl -1,2,3, 4-tetrahydroisoquinoline can be used to prepare Sofenasin. Solifenacin succinate (SolifenacinSuccinate),CAS No. 242478-38-2, chemical name 1-azabicyclo [2.2.2] octane -8-yl-(1S)-1-phenyl -3, 4-dihydro-1H-isoquinoline -2-formate succinate, is a selective muscarinic M3 receptor antagonist developed by Japan Astellas Company. It was first listed in Holland, Germany, Britain and Denmark in 2004 and in China in 2009, so far, it has been marketed in more than 50 countries and regions around the world, and has become an important drug for the treatment of overactive bladder (OAB) in Europe, the United States and Japan, and has been recommended by many authoritative organizations and guidelines. The preparation is as follows: (S)-1-phenyl -1,2,3, 4-tetrahydroisoquinoline (I) is condensed with triphosgene under the condition of organic base (weak base) to obtain (S)-1-phenyl -3, 4-dihydro-1 H-isoquinoline -2-formyl chloride (II), compound II can not be separated, direct heating under organic base catalysis by a one-pot method, condensation reaction with (R)-3-quinine cycloalcohol to obtain solinasine (III), and then salt with succinic acid to obtain solinasine succinate (IV). |
| synthesis | add 10mL of methanol solution of 1-phenyl -1,2,3,4-tetrahydroisoquinoline (racemate raw material) 2750mg (chemical purity 87.4 mass%,11.5mmol) to the solution formed by L-tartaric acid 1726mg(11.5mmol,1 equivalent) and methanol 10mL, and cool to 5 ℃, precipitation of crystals. Stir for 1 h, and then filter under reduced pressure to remove the precipitated (R)-1-phenyl -1,2,3, 4-tetrahydroisoquinoline/L-tartaric acid salt (R-type tartrate crystal). The optical purity of (S)-1-phenyl -1,2,3, 4-tetrahydroisoquinoline S-type raw material in the obtained mother liquor was determined as 83% e.e.. Add 20mL of water to it and distill under reduced pressure to remove methanol. Add 30% by mass sodium hydroxide aqueous solution to the obtained solution (19.65g) until pH 12, and precipitate crystals. Cool to 5 ℃, stir for 30 minutes, then filter the crystals under reduced pressure, wash with 20mL of water, and dry in vacuum to obtain white crystals of (S)-1-phenyl -1,2,3, 4-tetrahydroisoquinoline (S-type raw material) (S)-1-phenyl -1,2,3, 4-tetrahydroisoquinoline (1092mg, chemical purity 93% by mass, 4.83mmol, yield 42 mol%, optical purity 82% e.e.). |
Last Update：2024-04-09 21:04:16
Supplier List
Spot supply
Product Name: Solifenacin Impurity 20（Solifenacin EP Impurity A） Visit Supplier Webpage Request for quotationCAS: 118864-75-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: (S)-1-Phenyl-1,2,3,4-Tetrahydroisoquinoline Visit Supplier Webpage Request for quotationCAS: 118864-75-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: (1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline Request for quotation
CAS: 118864-75-8
Tel: 86-10-10086 81625225
Email: yeqim@boyechemicals.com
Mobile: 86-15387090420
QQ: 1377812380
Wechat: 15387090420
CAS: 118864-75-8
Tel: 86-10-10086 81625225
Email: yeqim@boyechemicals.com
Mobile: 86-15387090420
QQ: 1377812380
Wechat: 15387090420
Product Name: (1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline Request for quotation
CAS: 118864-75-8
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: 13651600618
WhatsApp: +8613651600618
CAS: 118864-75-8
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: 13651600618
WhatsApp: +8613651600618
Spot supply
Product Name: Solifenacin Impurity 20（Solifenacin EP Impurity A） Visit Supplier Webpage Request for quotationCAS: 118864-75-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: (S)-1-Phenyl-1,2,3,4-Tetrahydroisoquinoline Visit Supplier Webpage Request for quotationCAS: 118864-75-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: (1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline Request for quotation
CAS: 118864-75-8
Tel: 86-10-10086 81625225
Email: yeqim@boyechemicals.com
Mobile: 86-15387090420
QQ: 1377812380
Wechat: 15387090420
CAS: 118864-75-8
Tel: 86-10-10086 81625225
Email: yeqim@boyechemicals.com
Mobile: 86-15387090420
QQ: 1377812380
Wechat: 15387090420
Product Name: (1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline Request for quotation
CAS: 118864-75-8
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: 13651600618
WhatsApp: +8613651600618
CAS: 118864-75-8
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: 13651600618
WhatsApp: +8613651600618
View History