(S)-2-HYDROXYPROPIONIC ACID SODIUM SALT
Sodium (S)-lactate
CAS: 867-56-1
Molecular Formula: C3H7NaO3
(S)-2-HYDROXYPROPIONIC ACID SODIUM SALT - Names and Identifiers
| Name | Sodium (S)-lactate |
| Synonyms | SODIUM L-LACTATE Sodium (S)-lactate L-Lactic acid sodium salt S-LACTIC ACID SODIUM SALT SODIUM L-LACTATE SOLUTION SARCOLACTIC ACID SODIUM SALT SODIUM-L-2-HYDROXY-PROPIONATE L-Lactic acid sodium salt, Extra Pure (S)-2-HYDROXYPROPIONIC ACID SODIUM SALT 2-hydroxy-,monosodiumsalt,(s)-propanoicaci (S)-2-Hydroxypropanoic acid monosodium salt |
| CAS | 867-56-1 |
| EINECS | 212-762-3 |
| InChI | InChI=1/C3H6O3.Na/c1-2(4)3(5)6;/h2,4H,1H3,(H,5,6);/q;+1/p-1 |
(S)-2-HYDROXYPROPIONIC ACID SODIUM SALT - Physico-chemical Properties
| Molecular Formula | C3H7NaO3 |
| Molar Mass | 114.08 |
| Density | 1.33 |
| Melting Point | 163-165 °C (lit.) |
| Boling Point | 115℃[at 101 325 Pa] |
| Water Solubility | soluble |
| Solubility | It is miscible with water and alcohol, and its aqueous solution is neutral |
| Appearance | Powder |
| Color | White to yellow |
| BRN | 4567087 |
| Storage Condition | 2-8°C |
| Stability | Hygroscopic |
| Sensitive | Hygroscopic |
| Refractive Index | 1,422-1,425 |
| MDL | MFCD00066576 |
| Physical and Chemical Properties | density 1.33 melting point 163-165°C water-soluble solution |
| Use | Is a natural food additive, used as antioxidant Synergist, emulsifier, as a moisturizing agent in the cosmetics industry |
(S)-2-HYDROXYPROPIONIC ACID SODIUM SALT - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 1 |
| FLUKA BRAND F CODES | 3-10 |
| TSCA | Yes |
| HS Code | 29181100 |
(S)-2-HYDROXYPROPIONIC ACID SODIUM SALT - Upstream Downstream Industry
| Raw Materials | Sodium hydroxide DL-Lactic acid L(+)-Lactic acid |
(S)-2-HYDROXYPROPIONIC ACID SODIUM SALT - Reference
| Reference Show more | Peng Mingbing, Zheng Zhiju, Zeng Zhirui et al. Neutral lactic acid promotes proliferation, migration and invasion of liver cancer cells through PI3K/Akt signaling pathway [J]. Tumor 2020 v.40;No.323(01):15-25. |
(S)-2-HYDROXYPROPIONIC ACID SODIUM SALT - Compound Sodium Lactate and Glucose Injection
Authoritative Data Verified Data
This product is sodium lactate, sodium chloride, potassium chloride, calcium chloride and anhydrous glucose sterilization solution. Containing sodium lactate (C3H5NaO3) shall be 93.0% to 107.0% of the labeled amount, containing sodium chloride (NaCl), potassium chloride (KC1), calcium chloride (CaCl2 • 2H20) and anhydrous glucose (C6Hl205) should be 95.0% to 110.0% of the labeled amount.
prescription
sodium lactate 3.10g
Sodium chloride 6.00g
Potassium chloride 0.30g
Calcium chloride (CaCl2 • 2H20) 0.20g
Anhydrous glucose 50.0G
Appropriate amount of water for injection
Made up to 1000ml
trait
This product is colorless to yellowish clear liquid.
identification
- take 5ml of this product, slowly drop into the warm alkaline copper tartrate color to take this product, and compare with the yellow 6th Standard Colorimetric solution (in the first test solution of 0901, that is, the red precipitation method of cuprous oxide), not deeper.
- This product is sodium salt identification (1), potassium salt, calcium salt identification (2), lactate and chloride identification (1) reaction (General 0301).
examination
- the pH value should be 3.6 to 6.5 (General 0631).
- S-hydroxymethyl furfural precision take 5ml of this product, put it in a 50ml measuring flask, dilute it with water to the scale, shake it well, according to UV-visible spectrophotometry (General rule 0401), the absorbance shall not be greater than 0.25 when measured at a wavelength of 284nm.
- take 100ml heavy metal of this product, put it on a water bath and evaporate to dryness, slowly burn it until it is completely carbonized, let it cool, add 2ml nitric acid and 5 drops of sulfuric acid, and heat it at low temperature until the white smoke is removed, fully ash by cauterization at 500~600°C, cool, add 2ml hydrochloric acid, heat for 2 min on water bath, add 1 drop phenolphthalein indicator solution, add ammonia test solution Dropwise to microscopic red, filter, the filtrate was placed in a Nessler's colorimetric tube, added with 2ml of acetate buffer (pH 3.5) and an appropriate amount of water to make 25ml, and checked according to law (General rule 0821, Method 2), containing no more than 2 parts of heavy metals.
- The osmolality should be 540 to 590 mosmol/kg (General 0632).
- arsenic salt: take 40ml of this product, evaporate to about 5ml on a water bath, add 5ml of dilute sulfuric acid and 1ml of bromine test solution, evaporate to about 5ml on the water bath, and let it cool, add hydrochloric acid 5ml and water 18ml, inspection according to law (General Principles 0822 The first law), should comply with regulations (0.000005%)
- pyrogen to take this product, according to the law (General rule 1142), the dose of rabbit body weight per lkg slow injection of 10ml, should comply with the provisions.
- others should comply with the relevant provisions under injection (General 0102).
determination of content
- potassium chloride an appropriate amount of potassium chloride dried at 105 ° C. For 2 hours was accurately weighed, dissolved in water and quantitatively diluted to prepare a solution containing about 15ug per 1 ml as a solution of a reference product.
- take 10ml of this product with precision, put it in a 100ml measuring flask, dilute it to scale with water, shake it well, take 10ml with precision, put it in a 100ml measuring flask, dilute it to scale with water, shake it well, as a test solution.
- determination precision: take 15ml, 20ml and 25ml of the reference solution, respectively put it in a 100ml measuring flask, and add mixed solution (sodium lactate 0.31g, sodium chloride 0.60g, calcium chloride (CaCl2 • 2H20) 5.00g, anhydrous glucose g, put in a measuring flask, add water to dissolve and dilute to scale] 1.0 mL, dilute to scale with water, shake. Each of the above solutions and the test solution were taken, measured and calculated at a wavelength of 0406 mn according to Atomic Absorption Spectrophotometry (general rule, Method 1).
- sodium chloride the appropriate amount of gasified sodium dried at ll0 °C for 2 hours was accurately weighed, dissolved by adding water and quantitatively diluted to prepare a solution containing about 20ug per 1 ml, which was shaken well and used as a reference solution.
- take 2ml of this product with precision, put it in a 100ml measuring flask, dilute it to the scale with water, shake it well, take 2ml with precision, put it in a 100ml measuring flask, dilute it to the scale with water, shake it well, as a test solution.
- measurement precision: 10ml, 15ml and 20ml of the reference solution were respectively placed in a 100ml measuring flask, diluted with water to scale, and shaken. Each of the above solutions and the test solution are taken, measured at a wavelength of 0406 NM according to Atomic Absorption Spectrophotometry (the first method of general rule 1), and calculated by the following formula.
- preparation of calcium chloride reference solution about 110g of calcium carbonate reference material dried at 0.3125°C for 2 hours was accurately weighed, placed in a 500ml measuring flask, and dissolved with 1 mol/L hydrochloric acid solution 25mr, dilute to scale with water to make a solution containing 250ug of calcium per 1 ml and shake.
- preparation of lanthanum solution 6.6g of lanthanum oxide was weighed, dissolved by adding 10ml of hydrochloric acid, diluted to ML with water, and shaken.
- preparation of test solution: take 10ml of this product, put it in a 50ml measuring flask, add 2ml of lanthanum solution, dilute it with water to the scale, and shake it well.
- determination precision: take lml, 2ml and 3ml of reference solution, put them in 50ml measuring flask respectively, and add mixed solution (sodium lactate 0.31g, sodium chloride 0.60g, potassium chloride 0.03g, in a 100ml measuring flask, add water to dissolve and dilute to the scale, shake well) 10ml and 2ml of lanthanum solution, dilute to the scale with water, shake well. Each of the above-mentioned solutions and the test solution was taken by atomic absorption spectrophotometry (General rule 0406, Method 1), measured at a wavelength of 422.7nm, and calculated.
- preparation of sodium lactate cation exchange resin 10-15g of sodium salt sulfonic acid type ion exchange resin was taken, soaked in water, and heated at 80°C for about 1 hour, together with the water transfer to the ion exchange column, add 30-40ml of 2mol/L hydrochloric acid solution from the top, open the piston, and keep the added hydrochloric acid solution flowing out at a flow rate of 10ml per minute, again, hot water at 60-70°C was maintained at a flow rate of 20-30ml per minute until the wash liquid was free of chloride. Then flow through the resin column with 30ml of sodium chloride solution (1-20), then rinse with water, thus repeatedly treating 2-3 times with 2mol/L hydrochloric acid solution and sodium chloride solution (1-20), before use, treat with 2mol/L hydrochloric acid solution, rinse with fresh boiling cold water of about 300 ~ 500ml to almost no chloride, and take 100ml of the final wash solution, add 2~3 drops of phenolphthalein indicator solution and sodium hydroxide titration solution (0.1 mol/L) 1 drop, such as pink, can be used for the test.
- measurement precision: take 25ml of this product and move it into the above ion exchange column, let it stand for 5 minutes, use a 250ml Erlenmeyer flask as a receiver, open the piston, and keep it flowing out at a flow rate of about 2ml for 1 minute. After all the samples enter the resin column, wash with water at the same flow rate for 2 times, 20ml each time, combine the effluent and the washing solution, and add 3-5 drops of phenolphthalein indicator solution, titration with sodium hydroxide titration solution (0.1 mo1/ L), minus the consumption of chlorine in the Test Volume of silver nitrate titration solution (0.1 mol/L) amount (ml), minus the sodium hydroxide titration solution (O. 1 mol/L) amount (ml), calculated, obtained. Each 1 ml of sodium hydroxide titration solution (0.1 mol/L) corresponds to 11.21mg of C3H5Na03.
- free acid precision measure 25ml of this product, add 3-5 drops of phenolphthalein indicator solution, and titrate with sodium hydroxide titration solution (0.lmol/L).
- anhydrous glucose this product is taken, and the optical rotation is measured at 25 ° C. According to the law (General rule 0621), and multiplied by 1.8958 to obtain the Weight (g) of C6H1206 in the Test quantity.
category
acid-base balance regulator.
specification
500ml
storage
sealed storage.
Last Update：2022-01-01 13:43:26
(S)-2-HYDROXYPROPIONIC ACID SODIUM SALT - Reference Information
| LogP | -1.52 at 20℃ |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Overview | sodium L-lactate is a natural L-lactate produced from lactic acid produced by fermentation of sucrose, PH is neutral (6.5-7.0), with mild salty taste. The product has a liquid and powder content of 60%. Is a kind of antiseptic effect of food additives. Sodium L-lactate is naturally present in foods. Natural sodium L-lactate is recognized as a safe and non-toxic food additive that has been approved for use in meat products by the U. S. Food and Drug Administration (FDA), the European Union (EU) and most countries in the world. Figure 1: Structural formula of sodium L-lactate. |
| production method | sodium lactate solution (867-56-1) is prepared by adding sodium hydroxide to lactic acid for neutralization under cooling, after being concentrated, it is allowed to stand for about one week, and then neutralized with alkali and diluted to obtain the finished product. |
| Use | sodium L-lactate is used for food preservation, moisture retention, flavor enhancement and as a pharmaceutical raw material for pharmaceutical manufacturing, it is also used as a casein toughener and water-absorbing agent. In terms of food antibacterial, sodium L-lactate can not only inhibit the majority of spoilage bacteria breeding, but also for many pathogenic bacteria, such as Listeria monocytogenes, salmonella, clostridium botulinum and the like have different degrees of inhibition, thus effectively extending the shelf life of meat products. L-sodium lactate has been successfully used in cooked ham, roast beef, chicken breast and other whole meat products and hot dog sausage, sausage, sausage and other minced meat products. No addition of L-sodium L-lactate ham in 15 days, the total number of bacteria reached 106; And the addition of L-sodium lactate ham, shelf life can be extended to 4 weeks. When sodium L-lactate is used in combination with other preservatives (such as potassium sorbate), The bacteriostatic effect is more significant. In addition to the antibacterial effect, sodium L-lactate in meat products also has the function of maintaining moisture, improving the yield, reducing the moisture precipitation of vacuum packaging products, antioxidant and increasing the flavor of meat. In addition, sodium L-lactate is also widely used as a moisturizing agent for skin care products, which can keep the skin water and reduce wrinkles. Sodium lactate is a natural wet factor, sodium lactate is responsible for 1/4 of the stratum corneum of human skin. Sodium lactate used in cosmetics can form a hydration film with other chemical components to prevent skin moisture volatilization, so that the skin quality easy moist state, prevent wrinkles, is widely used as a moisturizing agent for skin care products. Lactic acid also acts as a regulator of pH. L-lactate can be used as a new generation of skin whitening agents, which can produce synergistic effects when used in combination with other skin whitening agents. Sodium lactate can be used as a humectant in a variety of bath washes, such as body washes, bar soaps, and moisturizers. In liquid soap, soap and shampoo can be used as a pH regulator. In addition, the addition of bar soap can reduce the loss of water during storage, thus preventing the cracking of the soap; Sodium lactate is very effective in treating skin disorders. Such as: dry skin disease caused by extreme dry symptoms. L-lactic acid and L-lactate have antimicrobial effects and are used in anti-acne products. They often produce a synergistic effect when used in combination with many other active ingredients. used for food preservation, moisture, flavor and as pharmaceutical raw materials used in the manufacture of medicine, also used as casein toughening agent and water absorbing agent is a kind of natural food additive, used as antioxidant Synergist, emulsifier, as a moisturizing agent in the cosmetics industry |
| antibacterial mechanism | sodium L-lactate inhibits bacterial growth mainly by reducing the water activity (aW) of meat products. Lactate ions alter the osmotic pressure inside and outside the bacterial cell wall, thereby inhibiting bacterial growth. |
| dosage | the dosage of L-sodium lactate is generally between 2-5% of the weight of the product, according to the dosage of sodium L-lactate and the formulation of the product, the shelf life can be extended by 30-100%. Because the taste of sodium L-lactate is slightly salty, the use of sodium L-lactate in meat products can reduce the normal amount of salt (about 0.2%). Figure 2: sodium L-lactate powder |
| references | [1] http://bbs.foodmate.net/thread-69740-1-1.html. [2] http://www.med66.com/ [3]http://baike.baidu.com/link? url=wW6bxQz6_LBrkZ-ovbbAkiJgfj_ayR4L3-1X_am51MIwS97Hx37qeRzJOAYlhZydzH6onfyZ0O48pvIwhWYgkm7JDubP-kR9FeuB-HiSgyPVoTpz_fH7EMubg9aWTOO |
Last Update：2024-04-10 22:41:03
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Raw Materials for (S)-2-HYDROXYPROPIONIC ACID SODIUM SALT