(S)-3-(4-((4-(吗啉甲基)苄基)氧基)-1-氧代异吲哚啉-2-基)哌啶-2,6-二酮
Iberdomide
CAS: 1323403-33-3
Molecular Formula: C25H27N3O5
(S)-3-(4-((4-(吗啉甲基)苄基)氧基)-1-氧代异吲哚啉-2-基)哌啶-2,6-二酮 - Names and Identifiers
(S)-3-(4-((4-(吗啉甲基)苄基)氧基)-1-氧代异吲哚啉-2-基)哌啶-2,6-二酮 - Physico-chemical Properties
| Molecular Formula | C25H27N3O5 |
| Molar Mass | 449.5 |
| Density | 1.332±0.06 g/cm3(Predicted) |
| Boling Point | 717.8±60.0 °C(Predicted) |
| Solubility | DMSO: ≥30 mg/mL |
| pKa | 10.70±0.40(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | In cell degradation experiments, treatment with CC-220 resulted in the disappearance of Ikaros protein with an EC50 of 1 nM. CC-220 is equally effective for Aiolos, with an EC50 of 0.5 nM. CC-220 is a potent anti-proliferative, pro-apoptotic compound with activity against a variety of MM cell lines. CC-220 induced PBMC-mediated killing activity in multiple myeloma cells, regardless of the level of cereblon expression and cellular autonomic sensitivity. CC-220 can act by binding to cereblon, leading to degradation of the hematopoietic transcription factors Ikaros and Aiolos, and disruption of the MM-promoted c-Myc/IRF4 axis. |
(S)-3-(4-((4-(吗啉甲基)苄基)氧基)-1-氧代异吲哚啉-2-基)哌啶-2,6-二酮 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.225 ml | 11.123 ml | 22.247 ml |
| 5 mM | 0.445 ml | 2.225 ml | 4.449 ml |
| 10 mM | 0.222 ml | 1.112 ml | 2.225 ml |
| 5 mM | 0.044 ml | 0.222 ml | 0.445 ml |
Last Update：2024-01-02 23:10:35
(S)-3-(4-((4-(吗啉甲基)苄基)氧基)-1-氧代异吲哚啉-2-基)哌啶-2,6-二酮 - Reference Information
| biological activity | Iberdomide (CC-220) is a novel oral immunomodulatory compound, targeting cereblon(cereblon is part of the CRL4 CRBN E3 ubiquitin ligase complex) with an IC50 of 60 nM. Iberdomide (CC-220) induces apoptosis and has antitumor and Immunostimulatory activity. |
| Target | Value |
| cereblon () | 60 nM |
Last Update：2024-04-09 20:49:11
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Product Name: CC-220 Visit Supplier Webpage Request for quotationCAS: 1323403-33-3
Tel: 609-228-6898
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tech@medchemexpress.com
Mobile: 609-228-6898
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Product Name: Iberdomide Visit Supplier Webpage Request for quotationCAS: 1323403-33-3
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
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WhatsApp: +86-18621343501
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Product Name: Iberdomide Visit Supplier Webpage Request for quotationCAS: 1323403-33-3
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
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View History
(S)-3-(4-((4-(吗啉甲基)苄基)氧基)-1-氧代异吲哚啉-2-基)哌啶-2,6-二酮
2-[(2R,3R)-2-羟基-3-[(3-羟基-2-甲基苯甲酰)氨基]-4-(苯基硫)丁基]-(3S,4aS,8aS)-N-叔丁基十氢异喹啉-3-甲酰胺甲磺酸盐
TRIBUTYLHEPTYLAMMONIUM BROMIDE
4-三氟甲氧基苯硼酸
[R,(R﹡,R﹡)]-2-(4-氟苯基 )-β,α-二羟基-5-(1-甲基乙基)-3-苯基-[(苯胺基)-羟基]-1H-吡咯-1-庚酸钙盐
2-甲基-3-氧代-3-(吡嗪-2-基)丙酸甲酯
3-(苄氨基)氧杂环丁烷-3-羧酸
二氯[2-(4,5-二氢-2-噁唑基)喹啉]钯(II)
Estr-4-en-3-one, 17-beta-hydroxy-, 3-cyclopentylpropionate (ester)
4-氨基苯酚硫代磷酸酯
2-[(2R,3R)-2-羟基-3-[(3-羟基-2-甲基苯甲酰)氨基]-4-(苯基硫)丁基]-(3S,4aS,8aS)-N-叔丁基十氢异喹啉-3-甲酰胺甲磺酸盐
TRIBUTYLHEPTYLAMMONIUM BROMIDE
4-三氟甲氧基苯硼酸
[R,(R﹡,R﹡)]-2-(4-氟苯基 )-β,α-二羟基-5-(1-甲基乙基)-3-苯基-[(苯胺基)-羟基]-1H-吡咯-1-庚酸钙盐
2-甲基-3-氧代-3-(吡嗪-2-基)丙酸甲酯
3-(苄氨基)氧杂环丁烷-3-羧酸
二氯[2-(4,5-二氢-2-噁唑基)喹啉]钯(II)
Estr-4-en-3-one, 17-beta-hydroxy-, 3-cyclopentylpropionate (ester)
4-氨基苯酚硫代磷酸酯