(S)-3-(4-((4-(吗啉甲基)苄基)氧基)-1-氧代异吲哚啉-2-基)哌啶-2,6-二酮
Iberdomide
CAS: 1323403-33-3
Molecular Formula: C25H27N3O5
(S)-3-(4-((4-(吗啉甲基)苄基)氧基)-1-氧代异吲哚啉-2-基)哌啶-2,6-二酮 - Names and Identifiers
(S)-3-(4-((4-(吗啉甲基)苄基)氧基)-1-氧代异吲哚啉-2-基)哌啶-2,6-二酮 - Physico-chemical Properties
| Molecular Formula | C25H27N3O5 |
| Molar Mass | 449.5 |
| Density | 1.332±0.06 g/cm3(Predicted) |
| Boling Point | 717.8±60.0 °C(Predicted) |
| Solubility | DMSO: ≥30 mg/mL |
| pKa | 10.70±0.40(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | In cell degradation experiments, treatment with CC-220 resulted in the disappearance of Ikaros protein with an EC50 of 1 nM. CC-220 is equally effective for Aiolos, with an EC50 of 0.5 nM. CC-220 is a potent anti-proliferative, pro-apoptotic compound with activity against a variety of MM cell lines. CC-220 induced PBMC-mediated killing activity in multiple myeloma cells, regardless of the level of cereblon expression and cellular autonomic sensitivity. CC-220 can act by binding to cereblon, leading to degradation of the hematopoietic transcription factors Ikaros and Aiolos, and disruption of the MM-promoted c-Myc/IRF4 axis. |
(S)-3-(4-((4-(吗啉甲基)苄基)氧基)-1-氧代异吲哚啉-2-基)哌啶-2,6-二酮 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.225 ml | 11.123 ml | 22.247 ml |
| 5 mM | 0.445 ml | 2.225 ml | 4.449 ml |
| 10 mM | 0.222 ml | 1.112 ml | 2.225 ml |
| 5 mM | 0.044 ml | 0.222 ml | 0.445 ml |
Last Update：2024-01-02 23:10:35
(S)-3-(4-((4-(吗啉甲基)苄基)氧基)-1-氧代异吲哚啉-2-基)哌啶-2,6-二酮 - Reference Information
| biological activity | Iberdomide (CC-220) is a novel oral immunomodulatory compound, targeting cereblon(cereblon is part of the CRL4 CRBN E3 ubiquitin ligase complex) with an IC50 of 60 nM. Iberdomide (CC-220) induces apoptosis and has antitumor and Immunostimulatory activity. |
| Target | Value |
| cereblon () | 60 nM |
Last Update：2024-04-09 20:49:11
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Product Name: CC-220 Visit Supplier Webpage Request for quotationCAS: 1323403-33-3
Tel: 609-228-6898
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tech@medchemexpress.com
Mobile: 609-228-6898
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Product Name: Iberdomide Visit Supplier Webpage Request for quotationCAS: 1323403-33-3
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
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WhatsApp: +86-18621343501
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Product Name: Iberdomide Visit Supplier Webpage Request for quotationCAS: 1323403-33-3
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
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View History
(S)-3-(4-((4-(吗啉甲基)苄基)氧基)-1-氧代异吲哚啉-2-基)哌啶-2,6-二酮
1-(2-(二氟甲氧基)苯基)乙酮
4-((1S)-1-AMINO-1-CARBOXYETHYL)BENZOIC ACID
[2,3-13C2]-2,3-丁二酮
tert-butyl N-[(1-hydroxy-2-methylpropan-2-yl)oxy]carbamate
2-methyl-5-iodobenzoic acid
富马酸替诺福韦二吡呋酯
1,6-萘啶-2-羧酰胺盐酸盐
styryl acetate
Morantel EP Impurity B L-Tartrate (cis-Morantel L-Tartrate)
1-(2-(二氟甲氧基)苯基)乙酮
4-((1S)-1-AMINO-1-CARBOXYETHYL)BENZOIC ACID
[2,3-13C2]-2,3-丁二酮
tert-butyl N-[(1-hydroxy-2-methylpropan-2-yl)oxy]carbamate
2-methyl-5-iodobenzoic acid
富马酸替诺福韦二吡呋酯
1,6-萘啶-2-羧酰胺盐酸盐
styryl acetate
Morantel EP Impurity B L-Tartrate (cis-Morantel L-Tartrate)