(S)-5-(BROMOMETHYL)-2-PYRROLIDONE

(S)-5-(BROMOMETHYL)-2-PYRROLIDONE - Names and Identifiers

Name	(5S)-5-(bromomethyl)pyrrolidin-2-one
Synonyms	5β-(Bromomethyl)pyrrolidine-2-one (S)-5-(BROMOMETHYL)-2-PYRROLIDONE (S)-5-BROMOMETHYL-2-OXOPYRROLIDINE (5S)-5-(Brommethyl)pyrrolidin-2-on (S)-5-(Bromomethyl)-2-Pyrrolidinone (S)-5-(BROMOMETHYL)-2-PYRROLIDINONE (5S)-5-(bromomethyl)pyrrolidin-2-one (5S)-5-(Bromomethyl)pyrrolidin-2-one (5S)-5β-(Bromomethyl)pyrrolidine-2-one 2-pyrrolidinone, 5-(bromomethyl)-, (5S)- 2-Pyrrolidinone, 5-(bromomethyl)-, (5S)- [S,(-)]-5β-(Bromomethyl)pyrrolidine-2-one 2-Pyrrolidinone,5-(bromomethyl)-,(5S)-(9CI)
CAS	72479-05-1
InChI	InChI=1/C5H8BrNO/c6-3-4-1-2-5(8)7-4/h4H,1-3H2,(H,7,8)/t4-/m0/s1

(S)-5-(BROMOMETHYL)-2-PYRROLIDONE - Physico-chemical Properties

Molecular Formula	C5H8BrNO
Molar Mass	178.03
Density	1.541±0.06 g/cm3(Predicted)
Melting Point	75-79°C
Boling Point	102-106 °C(Press: 0.1 Torr)
Flash Point	157.1°C
Vapor Presure	0.000115mmHg at 25°C
Appearance	White powder
pKa	15.39±0.40(Predicted)
Storage Condition	2-8°C
Refractive Index	1.506
MDL	MFCD01632456

(S)-5-(BROMOMETHYL)-2-PYRROLIDONE - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R43 - May cause sensitization by skin contact R36 - Irritating to the eyes R22 - Harmful if swallowed
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36/37 - Wear suitable protective clothing and gloves.
WGK Germany	3
HS Code	29339900

(S)-5-(BROMOMETHYL)-2-PYRROLIDONE - Reference Information

Application

(S)-5-bromomethyl-2-pyrrolidone can be used as intermediates in organic synthesis and pharmaceutical intermediates, mainly used in laboratory research and development process and chemical production process.

preparation

(S)-5-methyl-2-pyrrolidone as raw material, NBS as bromination reagent, BPO
as initiator, (S)-5-bromomethyl-2-pyrrolidone was obtained by radical bromination reaction in carbon tetrachloride solution. (S)-5-methyl-2-pyrrolidone, 30mL
carbon tetrachloride, N-bromosuccinimide and benzoyl peroxide were added to the reaction system and reacted at 60 ℃ for 7H, the reaction was monitored by TLC
. After the reaction was completed, the solvent was distilled off under reduced pressure, and the obtained crude product was purified by column chromatography (V petroleum ether: V ethyl acetate = 10: 1). 1.20g of a light yellow solid was obtained.

Last Update：2024-04-09 21:11:58