(S)-DIOP

(S)-DIOP - Names and Identifiers

Name	(+)-2,2-dimethyl-4,5-((diphenylphosphino)dimethyl)dioxolane
Synonyms	(S)-DIOP (+)-DIOP (+)-2,2-dimethyl-4,5-((diphenylphosphino)dimethyl)dioxolane (+)-2,3-O-Isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosp (+)-4,5-Bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane (+)-4,5-Bis(Diphenylphosphinomethyl)-2,2-Dimethyl-1,3-Dioxolane (S,S)-4,5-Bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane (4S,5S)-(+)-4,5-Bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane (+)-1,4-Bis-(diphenylphosphino)-2,3-dihydroxy-2,3-O-isopropylidenebutane (S,S)-2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane (+)-1,4-Bis(diphenylphosphino)-1,4-dideoxy-2,3-O-isopropylidene-D-threitol {[(4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl]dimethanediyl}bis(diphenylphosphane) (4S,5S)-(+)-4,5-Bis(diphenylphosphinoMethyl)-2,2-diMethyl-1,3-dioxolane,(S,S)-DIOP. {[(4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl]bis(methylene)}bis(diphenylphosphine) 1,1'-[[(4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl]bis(methylene)]bis[1,1-diphenyl-Phosphine phosphine, 1,1'-[[(4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl]bis(methylene)]bis[1,1-diphenyl- (4S,5S)-(+)-Bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane(+)-DIOP(2S,3S)-(+)-2,3-O-Isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane
CAS	37002-48-5
EINECS	253-307-9
InChI	InChI=1/C31H32O2P2/c1-31(2)32-29(23-34(25-15-7-3-8-16-25)26-17-9-4-10-18-26)30(33-31)24-35(27-19-11-5-12-20-27)28-21-13-6-14-22-28/h3-22,29-30H,23-24H2,1-2H3/t29-,30-/m1/s1
InChIKey	VCHDBLPQYJAQSQ-LOYHVIPDSA-N

(S)-DIOP - Physico-chemical Properties

Molecular Formula	C31H32O2P2
Molar Mass	498.54
Melting Point	86-88°C(lit.)
Boling Point	590.3±25.0 °C(Predicted)
Specific Rotation(α)	+26° (c 2.0, CHCl3)
Flash Point	390.9°C
Water Solubility	Sparingly soluble in water at 25°C 2.1E-5 g/L.
Vapor Presure	2.75E-13mmHg at 25°C
Appearance	Powder
Color	White
BRN	1630280
Storage Condition	Store below +30°C.
Sensitive	Air Sensitive
MDL	MFCD00009760

(S)-DIOP - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany	3
FLUKA BRAND F CODES	10-23
HS Code	29319090

(S)-DIOP - Introduction

()-2,2-dimenthyl-4, 5-((diphenylphosphino)dimethyl)dioxolane, also known as ()-2,2-dimenthyl-4, 5-((diphenylphosphino)dimethyl)dioxolane, is an organic compound. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: Colorless to light yellow liquid
-Density: Approximately 1.12 g/mL
-melting point: about -62 ℃
-Boiling point: about 246 ℃
-Refractive index: about 1.531

Use:
( )-2,2-dimenthyl-4, 5-((diphenylphosphino)dimethyl)dioxolane is a chiral phosphine ligand, which is widely used in organic synthesis and metal-catalyzed reactions. It can form complexes with platinum, palladium, nickel, iron and other metals, and is used to catalyze various important chemical conversion reactions, such as asymmetric hydrogenation, Soxhlet coupling and ring-closing reactions. In addition, it can also be used as an intermediate in anticancer drug research.

Preparation Method: The synthesis of
( )-2,2-dimenthyl-4, 5-((diphenylphosphino)dimethyl)dioxolane is more complex, and a common synthesis method is prepared by the rearrangement reaction of the precursor isopropene-2, 3-dicrypthydroxy-1, 4-dipropylphosphinobutane.

Safety Information:
The compound has no known obvious danger under normal use conditions. However, as an organic compound, care should be taken to follow laboratory safety procedures and wear appropriate personal protective equipment. There is no clear toxicological data for this compound, so when using and handling, you should follow the general safety measures for organic compounds, and avoid contact with the skin and eyes, and avoid inhalation or ingestion. If an accident or discomfort occurs, seek medical attention immediately.

Last Update：2024-04-09 20:49:11