(S)-Oxiranemethanol

Name	S(-)-glycidol
Synonyms	S-Glycidoe (S)-Glycidol S(-)-glycidol (S)-(-)-Glycidol (S)-Oxiranemethanol [(2r)-oxiran-2-yl]methanol (R)-3-Hydroxy-1,2-epoxypropane (S)-(-)-GLYCIDOL ((S)-(-)-2,3-EPOXY-1-PROPANOL) (S)-(-)-2,3-Epoxy-1-propanol, (S)-(-)-Oxirane-2-methanol
CAS	60456-23-7
InChI	InChI=1/C3H6O2/c4-1-3-2-5-3/h3-4H,1-2H2
InChIKey	CTKINSOISVBQLD-VKHMYHEASA-N

Molecular Formula	C3H6O2
Molar Mass	74.08
Density	1.116g/mLat 20°C(lit.)
Melting Point	72-73 °C
Boling Point	66-67°C19mm Hg(lit.)
Specific Rotation(α)	-15 º (neat)
Flash Point	178°F
Solubility	Soluble in chloroform, DMSO and methanol.
Appearance	Liquid
Color	Pale yellow
BRN	79783
pKa	14.62±0.10(Predicted)
Storage Condition	-20°C
Refractive Index	n20/D 1.433(lit.)
Physical and Chemical Properties	Colorless to light yellow liquid, stored in a closed container at room temperature. Boiling point 163-164°C.
Use	For the synthesis of a variety of Chiral Pharmaceutical Intermediates

Hazard Symbols	T - Toxic
Risk Codes	R45 - May cause cancer R60 - May impair fertility R21/22 - Harmful in contact with skin and if swallowed. R23 - Toxic by inhalation R36/37/38 - Irritating to eyes, respiratory system and skin. R68 - Possible risk of irreversible effects R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin.
Safety Description	S53 - Avoid exposure - obtain special instructions before use. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
UN IDs	UN 2810 6.1/PG 2
WGK Germany	3
RTECS	RR0508100
FLUKA BRAND F CODES	10-21
HS Code	29109000
Hazard Class	6.1
Packing Group	III

NIST chemical information	Information provided by: webbook.nist.gov (external link)
application	(S)-glycidyl is a colorless to light yellow liquid under normal temperature and pressure, which belongs to epoxy compounds and is often used in organic synthesis Chiral pharmaceutical intermediates are synthesized by epoxy ring opening reaction in its structure. In addition,(S)-glycidyl can be used to construct the molecular skeleton of cyclin and prostaglandin.
synthesis method	to 1.2 liters of dichloromethane, add 200 grams (S)-3-chloro -1,2-propanediol (99.5% ee) and 419 grams of potassium phosphate, the obtained mixed solution is refluxed and reacted under stirring for 3 hours, then the obtained solution is cooled to room temperature and filtered to remove insoluble solid precipitate, then the dichloromethane is evaporated under reduced pressure, and the residue is purified by fractionation (66 degrees/19 mmHg) to obtain 122 grams of target compound:(S)-glycidyl, yield: 122 grams, 91.0% chemical purity: 99.0% optical purity (GC)99.5%. Figure (S)-synthetic route of glycidyl
Uses	is used to synthesize chiral (E)-allyl alcohol side chains, which can be introduced into prostacyclin and prostaglandin skeletons through cross metathesis reactions. for the synthesis of a variety of chiral pharmaceutical intermediates

Last Update：2024-04-09 21:54:55

Product Name: (S)-Oxiranemethanol Request for quotation
CAS: 60456-23-7
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987

Wechat: 13605431940
WhatsApp: 13605431940

Product Name: (S)-Oxiranemethanol Request for quotation
CAS: 60456-23-7
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987

Wechat: 13605431940
WhatsApp: 13605431940

View History

(S)-Oxiranemethanol

(S)-Oxiranemethanol Request for Quotation