(S)-TERT-LEUCINOL
(S)-tert-Leucinol
CAS: 112245-13-3
Molecular Formula: C6H15NO
(S)-TERT-LEUCINOL - Names and Identifiers
| Name | (S)-tert-Leucinol |
| Synonyms | L-T-LEUCINOL L-TERT-LEUCINOL (S)-TERT-LEUCINOL (S)-tert-Leucinol L-T-BUTYLGLYCINOL L-(+)-TERT-LEUCINOL 2-AMINO-3,3-DIMETHYL-1-BUTANOL (S)-2-AMINO-3,3-DIMETHYLBUTANOL (S)-2-AMINO-3,3-DIMETHYL-1-BUTANOL (S)-2-Amino-3,3-dimethyl-1-butanol (2S)-2-amino-3,3-dimethylbutan-1-ol (2S)-1-hydroxy-3,3-dimethylbutan-2-aminium |
| CAS | 112245-13-3 |
| InChI | InChI=1/C6H15NO/c1-6(2,3)5(7)4-8/h5,8H,4,7H2,1-3H3/p+1/t5-/m1/s1 |
| InChIKey | JBULSURVMXPBNA-RXMQYKEDSA-N |
(S)-TERT-LEUCINOL - Physico-chemical Properties
| Molecular Formula | C6H15NO |
| Molar Mass | 117.19 |
| Density | 0.9g/mLat 25°C(lit.) |
| Melting Point | 30-34°C(lit.) |
| Boling Point | 114-116 °C (10 mmHg) |
| Flash Point | 194°F |
| Solubility | soluble in Methanol |
| Vapor Presure | 0.0906mmHg at 25°C |
| Appearance | Colorless to white liquid or solid |
| Color | White or colorless |
| BRN | 3600321 |
| pKa | 12.88±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| Refractive Index | 38 ° (C=1.5, EtOH) |
| MDL | MFCD00192250 |
(S)-TERT-LEUCINOL - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-23 |
| HS Code | 29221990 |
(S)-TERT-LEUCINOL - Reference Information
| Introduction | (S)-tert-leucine is a white solid, which can be obtained by reducing carboxyl groups from L-tert-leucine. The reducing agent can be selected From sodium borohydride and lithium tetrahydroaluminum. |
| preparation | add (83.04g,4eq) sodium borohydride, 2L dried tetrahydrofuran, L-tert-leucine 120g into a 5L three-mouth flask. Under the protection of nitrogen balloons, 760mL of 4 hydrofuran solution of iodine (231g,1eq) is slowly dropped in an ice bath at 0 ℃ to make it fully react. After dropping and stirring until no gas is released, then heat and reflux for 18 hours, cool to room temperature, and slowly drop 300ml of methanol to clarify the mixture. Stir for 30min to remove the white paste from the solvent, and then dissolve it in 800mL 20% KOH. In solution. The room temperature solution was stirred for 4h, and extracted with 1.5L dichloromethane 3 times each time, the organic phase was combined, washed with saturated salt water, dried with anhydrous sodium sulfate and concentrated by spin evaporation to obtain white semi-solid 97g yield 90%. |
Last Update：2024-04-09 21:54:55
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