(S,S)-Tadalafil

Name	ent-Tadalafil
Synonyms	ent-Tadalafil (S,S)-Tadalafil Tadanafil EP or USP impurity B Tadalafil Impurity B (ent-tadalafil) Tadalafil EP Impurity B ((6S,12S)-Tadalafil)
CAS	629652-72-8

Molecular Formula	C22H19N3O4
Molar Mass	389.4
Density	1.51±0.1 g/cm3(Predicted)
Melting Point	278-282°C
Boling Point	679.1±55.0 °C(Predicted)
Solubility	Chloroform (Slightly), Methanol (Slightly, Heated)
Appearance	Solid
Color	White
pKa	16.68±0.40(Predicted)
Storage Condition	-20°C Freezer

biological activity	ent-Tadalafil (ent-IC-351), compound (6S,12aS), is the inactive cis-enantiomer of compound (6R,12aS). The compound (6R,12aS) is a potent PDE5 inhibitor with an IC50 of 0.090 μM, while the ent-Tadalafil remains inactive at a high concentration of 10 µM.
target	PDE5 10 μM (IC 50 )

Last Update：2024-04-09 21:54:55

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(S,S)-Tadalafil

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