(Z)-4EGI-1 - Names and Identifiers
(Z)-4EGI-1 - Physico-chemical Properties
| Molecular Formula | C18H12Cl2N4O4S
|
| Molar Mass | 451.28 |
| Storage Condition | -20°C，干燥，密封 |
(Z)-4EGI-1 - Reference Information
| biological activity | (Z)-4 gi-1 is a Z-isomer of 4 gi-1, is an inhibitor of eIF4E/eIF4G interaction and translation initiation. (Z)-4 gi-1 effectively binds eIF4E with an IC50 of 43.5 μm and a Kd of 8.74 μm. (Z)-4 gi-1 has anti-cancer activity. |
| Target | IC50: 43.5 μm (eIF4E) Kd: 8.74 μm (eIF4E) |
|
Cell Line:
| CRL-2813 melanoma cells |
|
Concentration:
| 15 µM, 30 µM |
|
Incubation Time:
| 6 hours |
|
Result:
| Markedly reduced the expressions of the regulatory proteins: cyclin D1, cyclin E, and Survivin. |
Last Update：2024-04-09 20:52:54
