(melle-4)cyclosporin
(melle-4)cyclosporin
CAS: 143205-42-9
Molecular Formula: C62H111N11O12
(melle-4)cyclosporin - Names and Identifiers
(melle-4)cyclosporin - Physico-chemical Properties
| Molecular Formula | C62H111N11O12 |
| Molar Mass | 1202.64 |
| Density | 1.018±0.06 g/cm3(Predicted) |
| Boling Point | 1293.6±65.0 °C(Predicted) |
| pKa | 13.32±0.70(Predicted) |
| Storage Condition | -20°C |
| In vitro study | NIM811 induces a concentration-dependent reduction of HCV RNA in the replicon cells with an IC 50 of 0.66 μM at 48 h. In addition, the combination of NIM811 with alpha IFN significantly enhances anti-HCV activities without causing any increase of cytotoxicity. NIM811 blocks the mitochondrial permeability transition induced by calcium and inorganic phosphate. |
| In vivo study | NIM811 prevents mitochondrial depolarization thereby attenuates liver injury, stimulates regeneration and improves liver function and survival. |
(melle-4)cyclosporin - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 0.832 ml | 4.158 ml | 8.315 ml |
| 5 mM | 0.166 ml | 0.832 ml | 1.663 ml |
| 10 mM | 0.083 ml | 0.416 ml | 0.832 ml |
| 5 mM | 0.017 ml | 0.083 ml | 0.166 ml |
Last Update：2024-01-02 23:10:35
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