)-1-Methyl-3-pyrrolidinol
(R)-(−)-1-Methyl-3-pyrrolidinol
CAS: 104641-60-3
Molecular Formula: C5H11NO
)-1-Methyl-3-pyrrolidinol - Names and Identifiers
| Name | (R)-(− )-1-Methyl-3-pyrrolidinol |
| Synonyms | )-1-Methyl-3-pyrrolidinol (R)-N-Methyl-3-pyrrolidinol (R)-1-METHYL-3-PYRROLIDINOL (R)-1-Methyl-3-pyrrolidinol (R)-1-METHYLPYRROLIDIN-3-OL (3R)-1-methylpyrrolidin-3-ol (3R)-1-Methylpyrrolidin-3-ol (R)-(-)-1-METHYL-3-PYRROLIDINOL (R)-(-)-1-Methyl-3-pyrrolidinol 3-Pyrrolidinol,1-methyl-, (3R)- (R)-3-hydroxy-N-methylpyrrolidine (R)-(-)-1-METHYL-3-HYDROXYPYRROLIDINE |
| CAS | 104641-60-3 |
| EINECS | 626-120-9 |
| InChI | InChI=1/C5H11NO/c1-6-3-2-5(7)4-6/h5,7H,2-4H2,1H3/t5-/m1/s1 |
| InChIKey | FLVFPAIGVBQGET-RXMQYKEDSA-N |
)-1-Methyl-3-pyrrolidinol - Physico-chemical Properties
| Molecular Formula | C5H11NO |
| Molar Mass | 101.15 |
| Density | 0.921g/mLat 25°C(lit.) |
| Boling Point | 50-52°C1mm Hg(lit.) |
| Specific Rotation(α) | -7 º (c=1%, chloroform) |
| Flash Point | 159°F |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 0.132mmHg at 25°C |
| Appearance | Slightly yellow to slightly brown liquid |
| Color | Colorless to yellow to brown |
| BRN | 4349393 |
| pKa | 14.95±0.20(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Sensitive | Air Sensitive & Hygroscopic |
| Refractive Index | n20/D 1.4640(lit.) |
| MDL | MFCD03788747 |
| Use | Reactant for: Asymmetric synthesis of constrained (-)-S-adenosyl-L-homocysteine (SAH) analogs as DNA methyltransferase inhibitors Preparation of diaryl acylaminopyrimidines as adenosine A2A antagonists Synthesis of analogs of istaroxime, a potent inh |
)-1-Methyl-3-pyrrolidinol - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | NA 1993 / PGIII |
| WGK Germany | 3 |
| HS Code | 29339900 |
)-1-Methyl-3-pyrrolidinol - Introduction
(R)-(-)-1-methyl-3-pyrrolidinol, formula C6H11NO. The following is a description of its nature, use, preparation and safety information:
Nature:
(R)-(-)-1-methyl-3-pyrrolidinol is a colorless or light yellow liquid with a special smell. It is soluble in water and many organic solvents. It is a chiral compound with optical rotation of -24.3 °.
Use:
(R)-(-)-1-methyl-3-pyrrolidinol is an important chiral reagent in organic synthesis, which is often used in asymmetric synthesis. It can be used to prepare biologically active compounds, such as drugs and hormones. It is also used as a catalyst and ligand.
Preparation Method:
(R)-(-)-1-methyl-3-pyrrolidinol is prepared by a reaction catalyzed by a chiral inducer. A common method is to react 1-pyrrolidone with an enantioselective catalyst to give one of the enantiomers, and then to give the target compound by some chemical transformation.
Safety Information:
(R)-(-)-1-methyl-3-pyrrolidinol is an organic compound and is dangerous. It may cause irritation to the skin, eyes and respiratory system. Wear appropriate personal protective equipment to avoid inhalation, contact with skin and eyes. In addition, it should be handled in a well-ventilated area and properly stored and handled. Detailed safety operation information can be found in the relevant Safety Data Sheet (MSDS).
Nature:
(R)-(-)-1-methyl-3-pyrrolidinol is a colorless or light yellow liquid with a special smell. It is soluble in water and many organic solvents. It is a chiral compound with optical rotation of -24.3 °.
Use:
(R)-(-)-1-methyl-3-pyrrolidinol is an important chiral reagent in organic synthesis, which is often used in asymmetric synthesis. It can be used to prepare biologically active compounds, such as drugs and hormones. It is also used as a catalyst and ligand.
Preparation Method:
(R)-(-)-1-methyl-3-pyrrolidinol is prepared by a reaction catalyzed by a chiral inducer. A common method is to react 1-pyrrolidone with an enantioselective catalyst to give one of the enantiomers, and then to give the target compound by some chemical transformation.
Safety Information:
(R)-(-)-1-methyl-3-pyrrolidinol is an organic compound and is dangerous. It may cause irritation to the skin, eyes and respiratory system. Wear appropriate personal protective equipment to avoid inhalation, contact with skin and eyes. In addition, it should be handled in a well-ventilated area and properly stored and handled. Detailed safety operation information can be found in the relevant Safety Data Sheet (MSDS).
Last Update：2024-04-09 02:00:40
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