-DGG

Name	H-D-GLU(GLY-OH)-OH
Synonyms	-DGG DGG gamma- H-D-GLU(GLY-OH)-OH -D-glutamylglycine g-D-Glutamylglycine γ-D-Glutamylglycine Γ-D-GLUTAMYLGLYCINE γ-D-Glutamylglycine(γDGG) H-g-D-Glu-Gly-OH, DGG, g-DGG
CAS	6729-55-1

Molecular Formula	C7H12N2O5
Molar Mass	204.18
Density	1.424±0.06 g/cm3(Predicted)
Melting Point	～191℃
Boling Point	586.6±50.0 °C(Predicted)
pKa	2.21±0.10(Predicted)
Storage Condition	-15°C
In vitro study	gamma-DGG (γ-DGG), a competitive AMPA receptor blocker that blocks less at higher glutamate concentration. At 200-400 μM, gamma-DGG in the bath reduces the miniature EPSC (mEPSC) amplitude by 26±2% (n=5 synapses), and shifts both the mEPSC amplitude distribution and the cumulative probability curve to the left. gamma-DGG (γ-DGG) is the most effective antagonist of the excitatory post-synaptic potentials (e.p.s.p.s). Its action is reversible and not associated with any change in the passive membrane properties of the granule cells or in the apparent reversal potential of the e.p.s.p. Quantal analysis shows that the reduction in the e.p.s.p. paralleled the decrease in quantal size rather than quantal content, confirming a post-synaptic site of the action of gamma-DGG.

Last Update：2024-01-02 23:10:35

biological activity	gamma-DGG is a competitive AMPA receptor blocker.
Target	AMPA receptor

Last Update：2024-04-09 21:11:58

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CAS: 6729-55-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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