0DM021
ODM-201
CAS: 1297538-32-9
Molecular Formula: C19H19ClN6O2
0DM021 - Names and Identifiers
0DM021 - Physico-chemical Properties
| Molecular Formula | C19H19ClN6O2 |
| Molar Mass | 398.8462 |
| Density | 1.41±0.1 g/cm3(Predicted) |
| Boling Point | 719.5±60.0 °C(Predicted) |
| Solubility | DMSO: ≥ 44 mg/mL |
| pKa | 11.10±0.10(Predicted) |
| Storage Condition | -20℃ |
| MDL | MFCD29472270 |
| Physical and Chemical Properties | Bioactive Darolutamide (ODM-201, BAY-1841788) is a new androgen receptor (AR) antagonist, which can block AR nuclear transport with Ki of f 11 nM. Phase 3. |
0DM021 - Upstream Downstream Industry
0DM021 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.507 ml | 12.536 ml | 25.072 ml |
| 5 mM | 0.501 ml | 2.507 ml | 5.014 ml |
| 10 mM | 0.251 ml | 1.254 ml | 2.507 ml |
| 5 mM | 0.05 ml | 0.251 ml | 0.501 ml |
Last Update：2024-01-02 23:10:35
0DM021 - Uses and synthesis methods
target
Target Value
Androgen receptor 11 nM(Ki)
in vitro study
In AR-HEK293 cells that stably express full-length hAR, human AR (hAR) is ODM-201 inhibited, and the IC50 is 26 nM. ODM-201 inhibited VCaP cell proliferation, IC50 was 230 nM, but had no effect on the activity of the tested AR-negative cell lines, DU-145 prostate cancer cells and H1581 lung cancer cells.
in vivo studies
In mice loaded with VCaP xenografts, ODM-201 (50 mg/kg, p.o.) significantly inhibited the growth of castration-resistant prostate tumors.
Last Update：2024-04-09 21:21:28
Supplier List
Spot supply
Product Name: ODM-201 Visit Supplier Webpage Request for quotationCAS: 1297538-32-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: ODM-201 Visit Supplier Webpage Request for quotationCAS: 1297538-32-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History
Raw Materials for 0DM021
2-chloro-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)benzonitrile
2-Chloro-4-(1H-Pyrazol-5-Yl)Benzonitrile
2-Chloro-4-(1H-Pyrazol-5-Yl)Benzonitrile