1,1,7,7-Tetramethyl-8-hydroxy-9-formyljulolidine

1,1,7,7-Tetramethyl-8-hydroxy-9-formyljulolidine - Names and Identifiers

Name	9-Formyl-8-hydroxy-1,1,7,7-tetramethyljulolidine
Synonyms	9-Formyl-8-hydroxy-1,1,7,7-tetramethyljulolidine 1,1,7,7-Tetramethyl-8-hydroxy-9-formyljulolidine 8-HYDROXY-1,1,7,7-TETRAMETHYLJULOLIDINE-9-CARBOXALDEHYDE 8-Hydroxy-1,1,7,7-tetramethyl-1,2,3,5,6,7-hexahydro-pyrido[3,2,1-ij]quinoline-9-carbaldehyde 8-hydroxy-1,1,7,7-tetramethyl-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline-9-carbaldehyde 8-HYDROXY-1,1,7,7-TETRAMETHYL-2,3,6,7-TETRAHYDRO-1H,5H-PYRIDO[3,2,1-IJ]QUINOLINE-9-CARBOXALDEHYDE 9-Formyl-8-hydroxy-1,1,7,7-tetramethyljulolidine2,3,6,7-Tetrahydro-8-hydroxy-1,1,7,7-tetramethyl-1H,5H-benzo[ij]quinolizine-9-carboxaldehyde
CAS	115662-09-4
InChI	InChI=1/C17H23NO2/c1-16(2)5-7-18-8-6-17(3,4)13-14(18)12(16)9-11(10-19)15(13)20/h9-10,20H,5-8H2,1-4H3

1,1,7,7-Tetramethyl-8-hydroxy-9-formyljulolidine - Physico-chemical Properties

Molecular Formula	C17H23NO2
Molar Mass	273.37
Density	1.0101 (rough estimate)
Melting Point	74-77 °C
Boling Point	416.39°C (rough estimate)
Flash Point	187.9°C
Solubility	soluble in Methanol
Vapor Presure	1.51E-06mmHg at 25°C
Appearance	Light green crystal
Color	White to Light yellow to Green
pKa	9.50±0.60(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.5200 (estimate)

1,1,7,7-Tetramethyl-8-hydroxy-9-formyljulolidine - Risk and Safety

Safety Description	24/25 - Avoid contact with skin and eyes.
HS Code	29339900

1,1,7,7-Tetramethyl-8-hydroxy-9-formyljulolidine - Introduction

9-Aldehyd-8-hydroxy-1, 1,7, 7-tetramethyljulonidin is a compound, also known as furosemide, with the following properties and uses:

Nature:
-Appearance: White to light yellow crystalline powder.
-Solubility: Soluble in ethanol and chloroform, slightly soluble in water and ether.
-Melting point: about 181-183 ℃.
-storage conditions: should be stored in a dry, ventilated, dark place.

Use:
-Furosemide is a diuretic that is widely used in the treatment of diseases such as hypertension and heart failure.
-It can increase urine excretion by inhibiting sodium reabsorption by the renal tubules, thereby reducing fluid retention and reducing plasma volume.

Preparation Method:
-The preparation method of furosemide is more complicated, and the general steps include:
1.3,4-dimethylbutyraldehyde reacts with ethyl acetate to generate 4-ethoxy -2,2-dimethyl -3-hydrogen furan -5-one.
2. it is further converted into 9,9-dimethyl -7-ethoxyhydroxy -3-hydrogen -10H-furan [2,3-b] pyrazol-10-one by sodium chloride/sodium hydrogen acetate treatment and acidification.
3. Finally, 9-aldehyde -8-hydroxy -1,1,7,7-tetramethyljulonidine was obtained by reacting with aminoethyl trimethyl ammonium chloride.

Safety Information:
-Furosemide is a prescription drug and should only be used under the guidance of a doctor. It should not be purchased and taken by yourself.
-During the use of furosemide, attention should be paid to the monitoring of renal function and electrolyte levels to prevent possible side effects.
-Some patients may have an allergic reaction to furosemide. If allergic symptoms occur, stop the drug immediately and seek medical help.
-According to the individual situation, the doctor will adjust the dosage and medication time, and provide guidance and advice on the use.

Last Update：2024-04-09 15:17:51