1,1-Diphenylacetone
1,1-Diphenylacetone
CAS: 781-35-1
Molecular Formula: C15H14O
1,1-Diphenylacetone - Names and Identifiers
| Name | 1,1-Diphenylacetone |
| Synonyms | 1,1-Diphenylactone 1,1-DIPHENYLACETONE 1,1-Diphenylacetone UNSYM-DIPHENYLACETONE 1,1-diphenyl-2-propanon BENZHYDRYL METHYL KETONE 1,1-Diphenyl-2-propanone 1,1-DIPHENYLPROPAN-2-ONE 1,1-DIPHENYL-2-PROPANONE 1,1-diphenylpropan-2-one 2-OXO-1,1-DIPHENYLPROPANE methyldiphenylmethylketone |
| CAS | 781-35-1 |
| EINECS | 212-307-9 |
| InChI | InChI=1/C15H14O/c1-12(16)15(13-8-4-2-5-9-13)14-10-6-3-7-11-14/h2-11,15H,1H3 |
1,1-Diphenylacetone - Physico-chemical Properties
| Molecular Formula | C15H14O |
| Molar Mass | 210.27 |
| Density | 1.0232 (rough estimate) |
| Melting Point | 59-63 °C (lit.) |
| Boling Point | 135 °C (1.5 mmHg) |
| Flash Point | 133.8°C |
| Vapor Presure | 0.000719mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Almost white |
| BRN | 1910206 |
| Storage Condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. Combustible. |
| Refractive Index | 1.5361 (estimate) |
| MDL | MFCD00008759 |
| Physical and Chemical Properties | This product is a colorless solid, industrial products are yellow crystals, m.p.59 ~ 63 ℃, B. p.142 ~ 144 ℃/0.266kPa, relative density of 1.5361, insoluble in water. |
| Use | It can be used as an intermediate for the production of anticoagulant rodenticides, such as the rat sodium salt, the rat and the chlorophenone. It can also be used as a pharmaceutical intermediate such as prostaglandin I2 agonist. |
1,1-Diphenylacetone - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | UC2010020 |
| TSCA | Yes |
| HS Code | 29143990 |
1,1-Diphenylacetone - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | 1, 1-diphenylacetone is an intermediate of the rodenticide, rat-rat. used as an intermediate for rodenticide, Diphacinone. it can be used as an intermediate in the production of anticoagulant rodenticides, such as sodium salt of rat, rat and chlorophenone, and can also be used as a pharmaceutical intermediate such as prostaglandin I2 agonist |
| production method | obtained by Bromination and phenylation of phenylacetone ([103-79-7]). The preparation method is to bromination 1-phenyl-1-bromoacetone using 1-phenylacetone as a raw material to obtain 1-phenyl-1-bromoacetone, and then carry out Fourier reaction with benzene in the presence of anhydrous aluminum trichloride to obtain a product. It is also possible to use acetone to inject chlorine gas into the reaction Tower, and the liquid temperature is controlled at 25~40 ℃ to generate trichloroacetone. Then trichloroacetone is added to the reaction kettle, and the reducing agent solution is added dropwise at 60~80 ℃, the solvent was evaporated by heating after dropwise addition, and after 1-3 h, the temperature was raised to 110-120 ° C. And the reaction was completed. Then dilute hydrochloric acid is added into the hydrolysis kettle, and the above-mentioned reducing agent reaction solution is added dropwise under stirring for hydrolysis, layering, and the lower crude product is distilled under reduced pressure, the 80~85 ℃/8.0kPa fraction is trichloroisopropanol, which is cooled to obtain a slightly gray-white prismatic crystal. Then, benzene and anhydrous aluminum trichloride are added to the reaction kettle, A solution consisting of trichloroisopropanol and benzene is added dropwise under stirring, the reaction temperature is 30~40 ℃, and the reaction is completed for 1 h, and then the reactant is hydrolyzed to unreacted aluminum trichloride in the hydrolysis kettle, hydrolysis temperature is not more than 70 deg C, hydrolysis of the complete layer, under normal pressure to remove benzene, vacuum distillation products. |
Last Update：2024-04-09 21:11:58
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