Name | Pyruvic aldehyde dimethyl acetal |
Synonyms | 1,1-Dimethoxyacetone 1,1-dimethoxypropan-2-one PYRUVALDEHYDE DIMETHYLACETAL Pyruvaldehyde dimethyl acetal PYRUVALDEHYDE-1-DIMETHYL ACETAL Pyruvic aldehyde dimethyl acetal PYRUVIC ALDEHYDE DIMETHYL ACETAL PYRUVALDEHYDE 1,1-DIMETHYL ACETAL Methylglyoxal dimethyl acetal~Pyruvaldehyde dimethyl acetal PYRUVIC ALDEHYDE DIMETHYL ACETAL(INTERMEDIATE OF B-CAROTENE) |
CAS | 6342-56-9 |
EINECS | 228-735-4 |
InChI | InChI=1/C5H10O3/c1-4(6)5(7-2)8-3/h5H,1-3H3 |
InChIKey | ULVSHNOGEVXRDR-UHFFFAOYSA-N |
Molecular Formula | C5H10O3 |
Molar Mass | 118.13 |
Density | 0.976g/mLat 25°C(lit.) |
Melting Point | -57 °C |
Boling Point | 143-147°C(lit.) |
Flash Point | 100°F |
Water Solubility | MISCIBLE |
Vapor Presure | 11hPa at 20℃ |
Appearance | Liquid |
Color | Clear colorless to yellow |
BRN | 1560557 |
Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
Refractive Index | n20/D 1.398(lit.) |
Use | For the preparation of anti-tumor drugs, cytokines inhibitors, anti-cardiovascular drugs, antibiotics and other drugs |
Hazard Symbols | Xi - Irritant |
Risk Codes | R10 - Flammable R36/38 - Irritating to eyes and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S16 - Keep away from sources of ignition. |
UN IDs | UN 1224 3/PG 3 |
WGK Germany | 1 |
TSCA | Yes |
HS Code | 29145000 |
Hazard Class | 3 |
Packing Group | III |
Raw Materials | Methylglyoxal |
NIST chemical information | information provided by: webbook.nist.gov (external link) |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
preparation | pyruvic aldehyde monohydrate example: a reactor with an inner diameter of 10mm and a length of MM was selected, in which the constant temperature section was 55mm. The catalyst can be selected from Zn2 +, Ce4 +, Pb4 +, Pr3 +, La3 +, K +, ZrO2, α-al2o3, Cu +, SiO2, H3PO4, (NH4)H2PO4, agNO3 and others modified electrolytic silver, with a dose of 3mL, placed in the constant temperature section; The upper and lower parts were filled with quartz sand respectively, and the reaction product was condensed at the first level to obtain methylglyoxal monohydrate, the tail gas is then absorbed in multiple stages. The experimental device is made of stainless steel. 1,2-propylene glycol is injected by a double piston pump, water vapor is provided by a boiler and is measured by a flow meter, and air and nitrogen are compressed air, which is provided by a cylinder and is measured by a flow meter. The optimum synthesis conditions are as follows: reaction temperature 350~650 ℃, oxygen-alcohol ratio 1.1~1.2, air-nitrogen ratio 2.2~3.0, space velocity 18000~20000h -1. Under the above conditions, the conversion rate of 1,2 propylene glycol was 100%, and the selectivity of acetone aldehyde was 76%, The yield of methylglyoxal monohydrate was 60%. In a 100 ml three-necked flask equipped with a mechanical stirring device, reflux condenser, thermometer, G of pyruvic aldehyde monohydrate was added to the CH3COCHO.H2O 90%, industrial grade methanol 320.4 grams, modified resin catalyst 40 grams, vigorously stirred, heated reflux reaction for 16 hours; Cooled to room temperature, filtered, filtered modified resin catalyst; the filtrate is injected into 1000ml of a three-necked flask equipped with a mechanical stirring device, a thermometer and a distillation head with controllable reflux ratio for distillation, and low boiling substances such as methylal and methyl acetate are distilled out until the top temperature reaches 64 ℃; then methanol was recovered under the condition of variable reflux ratio, and the top temperature was maintained at 64~66 °c until the temperature in the flask reached 90 °c; The distillation was continued by passing water vapor into the lower part of the flask, collect the crude solution of acetone aldehyde dimethanol under the condition of slight negative pressure; Then extract the solution with 5 × 30ml of dichloromethane; Recover the aqueous phase (after pretreatment, to be used next time); Merge the organic phase, recovery of dichloromethane under normal pressure (39.5~40.5 ℃); And then refined, After distilling off the pre-fraction, 60.19G of a fraction of 64 to 66 ° C. (60mmHg) was collected, with a purity of 99.1% and a yield of 50.5%. |
uses | for the preparation of antitumor drugs, cytohormone inhibitors, anti-cardiovascular drugs, antibiotics and other drugs organic intermediates. This product is an important intermediate raw material in the field of chemical and pharmaceutical industry. The products produced by our company can meet all kinds of needs at home and abroad. It is a key intermediate raw material for the production of carotene |