1,1-diphenyl-1-(beta-dimethylaminopropyl)butanone-2hydrochloride
Methadone hydrochloride
CAS: 1095-90-5
Molecular Formula: CH3ClO
1,1-diphenyl-1-(beta-dimethylaminopropyl)butanone-2hydrochloride - Names and Identifiers
1,1-diphenyl-1-(beta-dimethylaminopropyl)butanone-2hydrochloride - Physico-chemical Properties
| Molecular Formula | CH3ClO |
| Molar Mass | 66.49 |
| Density | 1.0103 (rough estimate) |
| Melting Point | 232-2340C |
| Flash Point | 11°C |
| Water Solubility | 120 mg/mL |
| Solubility | Soluble in water, freely soluble in ethanol (96 per cent) |
| Appearance | powder |
| Color | white to off-white |
| Storage Condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Refractive Index | 1.5790 (estimate) |
| Physical and Chemical Properties | White crystalline powder. Melting point 235 ℃. Solubility (g/100ml): water 12, ethanol 8, isopropanol 2.4; Almost insoluble in ether and glycerol. |
1,1-diphenyl-1-(beta-dimethylaminopropyl)butanone-2hydrochloride - Risk and Safety
| Risk Codes | R25 - Toxic if swallowed R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. |
| UN IDs | UN 2811 |
| WGK Germany | 3 |
| RTECS | MJ6300000 |
| HS Code | 2922310000 |
| Toxicity | LD50 orally in rats: 95 mg/kg (Finnegan) |
1,1-diphenyl-1-(beta-dimethylaminopropyl)butanone-2hydrochloride - References
| indication | clinically applicable for trauma, cancer pain and postoperative sedation, due to its pharmacological effects similar to morphine, and the dependence is lower than that of opioids, so methadone is more used in the treatment of opiates. |
| Use | the analgesic effect of this product is similar to that of morphine. Apply to the elimination of trauma, surgery, advanced cancer and other causes of severe pain. |
| production method | diphenylacetonitrile (see 16180) is obtained by condensation, Grignard reaction and hydrolysis. |
Last Update：2024-04-09 20:48:19
