1,2,3,4-tetrahydroquinolin-5-ol
4-Aminoguinoline
CAS: 578-68-7
Molecular Formula: C9H8N2
1,2,3,4-tetrahydroquinolin-5-ol - Names and Identifiers
| Name | 4-Aminoguinoline |
| Synonyms | 4-QUINOLINAMINE 4-Quinolylamine 4-Aminoguinoline 4-Aminoquinoline quinolin-4-amine 4-AMINOQUINOLINE Quinolin-4-amine 4-aminoquinolinium QUINOLIN-4-YLAMINE 4-AMinoquinoline hydrochloride 1,2,3,4-tetrahydroquinolin-5-ol |
| CAS | 578-68-7 |
| EINECS | 640-116-4 |
| InChI | InChI=1/C9H8N2/c10-8-5-6-11-9-4-2-1-3-7(8)9/h1-6H,(H2,10,11)/p+1 |
1,2,3,4-tetrahydroquinolin-5-ol - Physico-chemical Properties
| Molecular Formula | C9H8N2 |
| Molar Mass | 144.17 |
| Density | 1.1148 (estimate) |
| Melting Point | 151.0 and le 155.0 °C |
| Boling Point | 312.78°C (estimate) |
| Flash Point | 181.2°C |
| Vapor Presure | 0.000147mmHg at 25°C |
| pKa | 9.17(at 20℃) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.7080 (estimate) |
1,2,3,4-tetrahydroquinolin-5-ol - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R36 - Irritating to the eyes R22 - Harmful if swallowed R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S39 - Wear eye / face protection. |
| UN IDs | 2811 |
| HS Code | 29334900 |
1,2,3,4-tetrahydroquinolin-5-ol - Introduction
4-Aminoguinoline(4-Aminoguinoline) is an organic compound with the chemical formula C9H7N2.
Nature:
-Appearance: 4-Aminoguinoline is a colorless crystal or white crystalline powder.
-Solubility: It is soluble in chloroform, methanol and ethyl acetate, slightly soluble in ethanol and ether, and almost insoluble in water.
-Melting point: The melting point of 4-Aminoguinoline is 90-92°C.
- pH value: The aqueous solution of the compound is neutral.
Use:
-Chemical reagent: 4-Aminoguinoline is widely used as a chemical reagent, such as a catalyst and intermediate in organic synthesis.
-Drug research: This compound is also used in drug research, such as the synthesis of anti-malaria drugs quinoline and anti-cancer drugs.
Preparation Method:
4-Aminoguinoline preparation methods are mainly the following:
-Obformed by the reaction of dichloroquinoline: 4-Aminoguinoline can be obtained by reacting dichloroquinoline with an amino compound, such as ammonia water.
-Synthesis by amide: Benzamide and ammonia react to produce 4-Aminoguinoline under the action of a catalyst.
Safety Information:
- 4-Aminoguinoline is irritating to the skin and should be rinsed with water immediately after contact.
-Wear protective gloves and glasses when operating 4-Aminoguinoline to avoid inhaling its dust.
-The toxicity of this compound is low, but you still need to pay attention to protective measures.
Please note that when using and handling any chemical substances, you should carefully read and follow the relevant safety instructions and operating instructions.
Nature:
-Appearance: 4-Aminoguinoline is a colorless crystal or white crystalline powder.
-Solubility: It is soluble in chloroform, methanol and ethyl acetate, slightly soluble in ethanol and ether, and almost insoluble in water.
-Melting point: The melting point of 4-Aminoguinoline is 90-92°C.
- pH value: The aqueous solution of the compound is neutral.
Use:
-Chemical reagent: 4-Aminoguinoline is widely used as a chemical reagent, such as a catalyst and intermediate in organic synthesis.
-Drug research: This compound is also used in drug research, such as the synthesis of anti-malaria drugs quinoline and anti-cancer drugs.
Preparation Method:
4-Aminoguinoline preparation methods are mainly the following:
-Obformed by the reaction of dichloroquinoline: 4-Aminoguinoline can be obtained by reacting dichloroquinoline with an amino compound, such as ammonia water.
-Synthesis by amide: Benzamide and ammonia react to produce 4-Aminoguinoline under the action of a catalyst.
Safety Information:
- 4-Aminoguinoline is irritating to the skin and should be rinsed with water immediately after contact.
-Wear protective gloves and glasses when operating 4-Aminoguinoline to avoid inhaling its dust.
-The toxicity of this compound is low, but you still need to pay attention to protective measures.
Please note that when using and handling any chemical substances, you should carefully read and follow the relevant safety instructions and operating instructions.
Last Update：2024-04-09 15:17:58
