1,2,3-Trichloropropane
1,2,3-Trichloropropane
CAS: 96-18-4
Molecular Formula: C3H5Cl3
1,2,3-Trichloropropane - Names and Identifiers
| Name | 1,2,3-Trichloropropane |
| Synonyms | Trichloropropane 1,2,3-TRICHLOROPROPANE 1,2,3-Trichloropropane 1,2,3-trichloro-propan GLYCEROL TRICHLOROHYDRIN 1 2 3-TRICHLOROPROPANE STANDARD FOR GC 1,2,3-TRICHLOROPROPANE, not stabilized, OEKANAL |
| CAS | 96-18-4 |
| EINECS | 202-486-1 |
| InChI | InChI=1/C3H5Cl3/c4-1-3(6)2-5/h3H,1-2H2 |
1,2,3-Trichloropropane - Physico-chemical Properties
| Molecular Formula | C3H5Cl3 |
| Molar Mass | 147.43 |
| Density | 1.387 g/mL at 25 °C (lit.) |
| Melting Point | -14 °C (lit.) |
| Boling Point | 156 °C (lit.) |
| Flash Point | 180°F |
| Water Solubility | 2 g/L (25 ºC) |
| Solubility | Soluble in alcohol and ether (Weast, 1986); miscible with propyl chloride, carbon tetrachloride,and chloroform. |
| Vapor Presure | 3.1 at 25 °C (Banerjee et al., 1990) |
| Appearance | neat |
| Color | Colorless to Almost colorless |
| Exposure Limit | TLV-TWA 10 ppm (～60 mg/m3) (ACGIH),50 ppm (MSHA, OSHA, and NIOSH); IDLH1000 ppm (NIOSH). |
| BRN | 1732068 |
| Storage Condition | 2-8°C |
| Refractive Index | n20/D 1.484(lit.) |
| Physical and Chemical Properties | Colorless flammable liquid. melting point -14.7 ℃ boiling point 156.8 ℃ relative density 1.3889 refractive index 1.4852 flash point 82.2 ℃ solubility slightly soluble in water. Soluble oil, grease, wax, chlorinated rubber and most resins. |
| Use | For the production of pesticides and organic synthesis, gas chromatography comparative samples |
1,2,3-Trichloropropane - Risk and Safety
| Risk Codes | R45 - May cause cancer R60 - May impair fertility R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable R38 - Irritating to the skin R68/20/21/22 - R48/23 - R48/21/22 - R36 - Irritating to the eyes R24/25 - R20 - Harmful by inhalation |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S37 - Wear suitable gloves. S36 - Wear suitable protective clothing. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S16 - Keep away from sources of ignition. S7 - Keep container tightly closed. |
| UN IDs | UN 2810 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | TZ9275000 |
| TSCA | Yes |
| HS Code | 29031980 |
| Hazard Class | 6.1 |
| Packing Group | III |
| Toxicity | Acute oral LD50 for rats 320 mg/kg (quoted, RTECS, 1985). |
1,2,3-Trichloropropane - Nature
Open Data Verified Data
colorless flammable liquid. Slightly soluble in water. Soluble oil, grease, wax, chlorinated rubber and most resins. The relative density was 1. 3889. Melting Point -14.7 °c. Boiling point 156.8 °c. Refractive index 4852. Flash point (Open Cup) 82.2 °c. Spontaneous ignition point 304.4.
Last Update：2024-01-02 23:10:35
1,2,3-Trichloropropane - Preparation Method
Open Data Verified Data
- a-allyl chloride propylene high temperature chlorination of allyl chloride, after washing, separation, and then low temperature chlorination, fractionation, that is to obtain the finished product.
- dichloroisopropanol method.
Last Update：2022-01-01 10:14:30
1,2,3-Trichloropropane - Use
Open Data Verified Data
It is mainly used to produce 1,2,3-allyl chloride, which is also a good solvent. It can also be used as the raw material of pesticide chlormequat and oat enemy.
Last Update：2022-01-01 10:14:30
1,2,3-Trichloropropane - Safety
Open Data Verified Data
- vapor is narcotic and its effect is similar to that of chloroform, but slower. Can invade the heart, liver, kidney and other internal organs. Operators should wear protective masks. The maximum allowable concentration in air is 150mg/m3.
- This product is flammable. The use of plastic or iron drum packaging. 200kg per barrel. Storage and transportation should be kept in a cool, ventilated place, away from the fire. According to the provisions of flammable chemicals storage and transportation.
Last Update：2022-01-01 10:14:30
1,2,3-Trichloropropane - Reference Information
| Henry's Law Constant | 34.5 at 25.0 °C (mole fraction ratio-GC, Leighton and Calo, 1981) |
| LogP | 2.63 at 25℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| (IARC) carcinogen classification | 2A (Vol. 63) 1995 |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| organic synthesis intermediate | trichloropropane is an important organic synthesis intermediate, which can be used for the preparation of glycerol, trichloropropene, triacetin, tetrachloropropene, 2-chloropropylamine, polychloropropane, 2, 4-dimethyl-3-acetylfuran; Trichloropropane is also the production of pesticide raw materials, can be used in the production of pesticide chlormequat and oat enemies. Trichloropropane is also a good solvent to remove metal surface coatings and paints. It is also used as a solvent for grease, wax, resin and chlorinated rubber. The polycondensation of trichloropropane with alkali metal polysulfide and BIS (dichlorovinyl) formal to form ST-type Polysulfide rubber. In addition, trichloropropane is also used as a standard substance for chromatographic analysis. |
| toxicity and hazard | (1) trichloropropane is toxic, corrosive and irritant, and can also be absorbed by the skin to cause poisoning, the vapor is narcotic, and its effect is similar to that of chloroform, but it is slower; It has a strong stimulating effect on the eyes and respiratory tract. Rat oral LD50320 mg/kg. (2) flammable, ignition point 580 F (304 C). The maximum allowable concentration of trichloropropane in air is 50ppm (300mg/m3) in the United States. |
| incompatibility | trichloropropane is incompatible with active metals, strong bases and strong oxidants. |
| adverse effects and toxic symptoms | trichloropropane is highly toxic by inhalation and moderately toxic by skin absorption. Human exposure to 100ppm is not permitted. It is a local irritant that irritates the eyes and throat and has an unpleasant odor. In addition, it also has a stimulating effect on the skin. Inhalation of high concentrations can cause central nervous system depression, and can affect the heart, liver, kidney and other internal organs. |
| first aid | if this chemical enters the eye, rinse immediately with water or eye wash; If it contacts the skin, wash quickly with soap and water; If there is a large amount of inhalation, immediately remove the scene to fresh air, if necessary, artificial respiration; If swallowed, give medical attention, taking a large amount of saline, induced Vomit, and sent to the hospital or a doctor for treatment. |
| preparation method | (1) trichloropropane is separated and extracted from a high-boiling mixture by-product in the production of epichlorohydrin. (2) trichloropropane can be obtained by chlorination of propylene as raw material. |
| Protection Measure | During operation, you should wear suitable work clothes to prevent repeated or prolonged skin contact. Wear protective glasses to prevent eye contact. Permeable work clothes, if wetted or contaminated, should be removed immediately. Safety signal indicators and eye washes should be provided at the operating site. |
| medical monitoring | before employment and regular medical examination, pay attention to the inspection of the invasion site. |
| determination method | determination of trichloropropane in air: analysis by activated carbon adsorption, CS2 treatment and gas chromatography. |
| store | in plastic or iron barrels to prevent mechanical damage. Store in a cool, ventilated, dry place, away from fire. |
| transportation requirements | trichloropropane is an organic flammable narcotic. Crisis#: 84007. The container must be marked with a "flammable drug" mark during transport. |
| proposed waste disposal method | incineration; Incineration after mixing with other combustible fuels is preferable. Care must be taken to ensure complete combustion to prevent phosgene generation. In order to remove the generated hydrohalic acid, it is necessary to prepare an acid scrubber. |
| Application | for the production of pesticides and organic synthesis, gas chromatography comparison samples mainly used for the production of 1,2, 3-trichloropropene is also a preferred solvent. It can also be used as the raw material of pesticide chlormequat and oat enemy. solvent. Detergent. Gas chromatographic comparison sample |
| production method | 1. Α-chloropropene chlorination propylene high temperature chlorination allyl chloride, after washing, separation, and then low temperature chlorination, fractionation, that is, to obtain the finished product. 2. Dichloroisopropanol method. |
| category | toxic substances |
| toxicity grade | high toxicity |
| Acute toxicity | oral-rat LD50: 140 mg/kg; Oral-mouse LD50: 369 mg/kg |
| stimulation data | Skin-rabbit 700 mg mild; Eye-rabbit 140 mg severe |
| explosive hazard characteristics | explosive when mixed with air |
| flammability hazard characteristics | Thermal decomposition; Toxic chloride gas generated during combustion; working with oxidants |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored separately from food additives |
| fire extinguishing agent | water mist, foam, carbon dioxide, dry powder. |
| Occupational Standard | TWA 300 mg/m3; Tel 450 mg/m3 |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
| immediate life-and health-threatening concentration | 100 ppm |
Last Update：2024-04-10 22:29:15
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