1,2,3-Trihydroxybenzen
Pyrogallol
CAS: 87-66-1
Molecular Formula: C6H6O3
1,2,3-Trihydroxybenzen - Names and Identifiers
| Name | Pyrogallol |
| Synonyms | Pyrogallol C.I. 76515 Pyrogallic acid Pyrogallol [NF X] 1,2,3-Benzenetriol 2,3-Dihydroxyphenol Pyrogallol solution benzene-1,2,3-triol 1,2,3-Trihydroxybenene 1,2,3-Trihydroxybenzen C.I. Oxidation Base 32 1,2,3-trihydroxy-benzen 1,2,3-Trihydroxybenzene Benzene, 1,2,3-trihydroxy- 1,2,3-trihydroxybenzen(czech) 1,2,3-trihydroxybenzene(pyrogallol) Pyrogallic acid~1,2,3-Trihydroxybenzene |
| CAS | 87-66-1 |
| EINECS | 201-762-9 |
| InChI | InChI=1/C6H6O3/c7-4-2-1-3-5(8)6(4)9/h1-3,7-9H |
| InChIKey | WQGWDDDVZFFDIG-UHFFFAOYSA-N |
1,2,3-Trihydroxybenzen - Physico-chemical Properties
| Molecular Formula | C6H6O3 |
| Molar Mass | 126.11 |
| Density | 1.112g/mLat 25°C(lit.) |
| Melting Point | 43-47°C(lit.) |
| Boling Point | 309 °C |
| Flash Point | >230°F |
| Water Solubility | 400 g/L (25 ºC) |
| Solubility | Soluble in water, ethanol, ether, slightly soluble in benzene, chloroform, carbon disulfide. |
| Vapor Presure | 10 mm Hg ( 167.7 °C) |
| Vapor Density | 4.4 (vs air) |
| Appearance | Powder |
| Color | White |
| Merck | 14,8000 |
| BRN | 907431 |
| pKa | pK1:9.03(0);pK2:11.63(+1) (25°C) |
| PH | 4-5 (50g/l, H2O, 20℃) |
| Storage Condition | Store below +30°C. |
| Stability | Stability Stable, but decolourises in light. Combustible. Incompatible with strong oxidising agents, alkalies, metal oxides, ammonia, antipyrine, phenol, iodine, lime water, menthol, potassium perman |
| Sensitive | Light Sensitive |
| Refractive Index | n20/D 1.387 |
| MDL | MFCD00002192 |
| Physical and Chemical Properties | White odorless crystals. Bitter taste. Exposure to air and light turned gray. Slowly heat and sublimate. The melting point is 133-134 ℃, the boiling point is 309 ℃, the relative density is 1.453, and the refractive index is 1.561. Soluble in water, ethanol, ether, benzene-soluble, chloroform, carbon disulfide. When exposed to air, the aqueous solution darkened in color, while the caustic solution changed color more rapidly. |
| Use | Used as analytical reagents, reducing agents and developers |
1,2,3-Trihydroxybenzen - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R68 - Possible risk of irreversible effects R40 - Limited evidence of a carcinogenic effect R36/38 - Irritating to eyes and skin. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S36/37 - Wear suitable protective clothing and gloves. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | UX2800000 |
| FLUKA BRAND F CODES | 8 |
| TSCA | Yes |
| HS Code | 2907 29 00 |
| Hazard Class | 6.1 |
| Packing Group | III |
| Toxicity | LD50 orally in rabbits: 1.6 g/kg (Dollahite) |
1,2,3-Trihydroxybenzen - Upstream Downstream Industry
| Downstream Products | 1,2,3-Trimethoxybenzene |
1,2,3-Trihydroxybenzen - Reference
| Reference Show more | 1. Huang Kuan to Runqing Lin Ai-he et al. Determination of four components in Phyllanthus emblica L. At different pH values by HPLC [J]. Journal of Yunnan College of Traditional Chinese Medicine, 2019 v.42;No.196(06):18-23. 2. Jiang Runsheng, Liu Menghu, Yi Xiangyu, etc. Effect of drying methods on quality and antioxidant capacity of Ginkgo biloba powder [J]. Food Science and Technology, 2019(12). 3. Yuan Zi-min, Liu Huan, Jia Tianzhu, et al. Antioxidant effects of alcohol extracts from nutmeg and processed products [J]. Journal of Changchun University of Traditional Chinese Medicine, 2015, 31(5):930-932. 4. Chu, Haijiao. Study on extraction technology of SOD from mycelium of Lentinus edodes [J]. Specialty studies (phase 1):32-34. 5. Yang Hui, Chen De Jing, Xia Dong Hui, etc. Study on extraction and antioxidation of skin pigment from Andrias davidianus [J]. Natural product research and development, 2019, 031(005):887-894. 6. Yang Hui, Chen De Jing, Chen Hai Tao, etc. Study on the properties and functions of skin pigment of Andrias davidianus [J]. Food Research and Development, 2019, 40(09):39-45. 7. Luo Min, Chen De Jing, Han Hao, et al. Antioxidant activity of selenium-modified rice germ polysaccharide [J]. Food Science, 2018, 39(19):65-70. 8. Que Fei, Huang Hannian, Zhao Xian. Changes of components and antioxidant activity during fermentation of banana enzyme [J]. Science and Technology of food industry, 2019, v.40;No.432(16):296-299 309. 9. Huang Renshu, Hu Xiaomeng, He Huili. Optimization of ultrasonic-assisted extraction of isoflavones from Pueraria lobata by response surface methodology and determination of reducing power [J]. Chinese Pharmaceutical Journal, 2015, 50(001):51-57. 10. Zhang Yu, Zhang Xiaona, Xue Qiao Li, etc. Antioxidant effect of mistletoe extract in vitro [J]. The Journal of Light Industry, 2016, 31(003):39-48. 11. Du Bowei, Xu Xiaobing, Guo Shangwei, etc. Study on small molecule donkey-hide gelatin with high antioxidant activity [J]. Journal of Beijing University of Chemical Technology: natural science, 2019, 46(6):15-20. 12. Zhang Yanjiao, Yang Ling, to Runqing, Huang Kuan, Fang Shan Dan, Fan Yuan, Zhu Peifang. Analysis and content of β-PGG hydrolysates from Galla Chinensis under different pH conditions [J]. Yunnan Journal of Traditional Chinese Medicine and Materia Medica, 2020,41(08):54-58. 13. Tingting, Chen Jiashu, Huang Guiying, Xin Yanping, Zeng Xiaofang, Chen Haiguang, Ye shaohuan, Zhang Yung, Feng Weihua, Huang Dexian. Effect of ozone on quality and antioxidant activity of preserved orange peel [J]. Modern food science and technology, 2020,36(09):109-116 25. 14. Liu Jingjing, Zhou Rong, Wang Yang Yiyi, Yu Xiaojin, Han Junping, Wang Xuefeng, Zhang Ran, Dai Yangjun. Study on antioxidant activity of Corbicula fluminea antioxidant peptide-zinc chelate [J]. Food Science and Technology, 2020,45(09):142-147. 15. [IF=4.952] Lihua Yang et al."Extraction of low molecular weight peptides from bovine bone using ultrasound-assisted double enzyme hydrolysis: Impact on the antioxidant activities of the extracted peptides."Lwt Food Sci Technol. 2021 Jul;146:111470 16. [IF=1.718] HUA Li Yue et al."Determination of SOD in black ginger extract and its effect on the liver of rats with type 2 diabetes."Food Sci Tech-Brazil. 2022 Mar;42: |
1,2,3-Trihydroxybenzen - Nature
Open Data Verified Data
white odorless crystals. Bitter taste. Exposure to air and light turned gray. Slowly heat and sublimate. The relative density was 1. 453. Melting point 133~134 °c, boiling point 309 °c. Refractive index 1.5 61. Soluble in water, ethanol, ether, benzene-soluble, chloroform, carbon disulfide. When exposed to air, the aqueous solution darkened in color, while the caustic solution changed color more rapidly.
Last Update：2024-01-02 23:10:35
1,2,3-Trihydroxybenzen - Preparation Method
Open Data Verified Data
obtained by decarboxylation of Gallic acid by heating.
Last Update：2022-01-01 10:41:54
1,2,3-Trihydroxybenzen - Use
Open Data Verified Data
can be used for the preparation of metal colloidal solution, leather coloring, fur, hair dyeing, etching, etc.; And can be used as film developer, infrared photographic heat-sensitive agent, Styrene inhibitor, pharmaceutical and dye intermediates and reagents for analysis.
Last Update：2022-01-01 10:41:54
1,2,3-Trihydroxybenzen - Safety
Open Data Verified Data
-
Highly toxic. On the skin, mucous membrane irritation is extremely strong, there have been cases of death by skin absorption poisoning. Swallowing can damage the digestive organs, liver, kidney, causing hemolysis, lethargy, collapse and even death. Rat oral LD50 789mg/kg. Dog oral LD25mg/kg. After contamination of the skin, should immediately take off the toxic clothing, shoes, socks, etc., with a large amount of water. The patient was sent to hospital for treatment immediately after swallowing. The operator should wear protective gear.
- The analytical pure reagent was filled with brown glass bottles, and each bottle was loaded with 10g. Chemical pure reagents and industrial products are packed in plastic and acetate fiber bags lined with wooden cases, each weighing 25kg. Be protected from light, sealed and moisture. According to the provisions of toxic substances storage and transportation.
Last Update：2022-01-01 10:41:55
1,2,3-Trihydroxybenzen - Reference Information
| LogP | -0.47 |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | for the preparation of metal colloidal solution, leather coloring, fur, hair dyeing, etching, etc; it can also be used as a developer of a film, an infrared photographic heat-sensitive agent, a styrene and polystyrene polymerization inhibitor, an intermediate of a medicine and a dye, an analytical reagent, and the like. Pyrogallic acid is used as an absorbent for oxygen in gas analysis, and is used in cosmetics for dusting powders, hair conditioners, hair dyes, and the like. mainly used for the production of developer, inhibitor and infrared photographic heat-sensitive agent, also used as pharmaceutical and dye intermediates used as analytical reagent, reducing agent and developer used for the analysis and determination of oxygen, antimony, bismuth, cerium, iron, molybdenum, tantalum and niobium; Used for oxygen absorption in gas analysis; Used for nitrite, molybdenum, niobium, titanium, cerium, bismuth, copper, vanadium, color reaction of iron, iodate, etc. metal complexing agent. Bismuth and antimony were determined gravimetrically. Reducing agents for gold, silver, mercury salts, phosphomolybdic acid, and phosphotungstic acid, used in gas analysis to absorb oxygen. Titanium, iron and aluminum were separated in the determination of tantalum and niobium. For nitrite, molybdenum, niobium, titanium, cerium, bismuth, copper, vanadium, iron, iodate color reaction. |
| production method | add gallic acid and water into the autoclave, decarboxylate at 200-210 °c for 0.5h, decolorize, filter, evaporation to produce the finished product, or vacuum sublimation purification. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:52:54
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