1,2-Proplenediamine
1,2-Diaminopropane
CAS: 78-90-0
Molecular Formula: C3H10N2
1,2-Proplenediamine - Names and Identifiers
| Name | 1,2-Diaminopropane |
| Synonyms | 12AP 1,2-PDA Propylenediamine PROPYLENEDIAMINE 2,3-diaminopropane 1,2-Propanediamine 1,2-DIAMINOPROPANE 1,2-PROPANEDIAMINE 1,2-Diaminopropane 1,2-Propane Diamine propane-1,2-diamine 1,2-Proplenediamine 1,2-PROPYLENEDIAMINE 1,2-Propylenediamine 2,3-Propylenediamine PROPYLENE-1,2-DIAMINE (2S)-propane-1,2-diamine (2S)-propane-1,2-diaminium |
| CAS | 78-90-0 |
| EINECS | 201-155-9 |
| InChI | InChI=1/C3H10N2/c1-3(5)2-4/h3H,2,4-5H2,1H3/t3-/m0/s1 |
| InChIKey | AOHJOMMDDJHIJH-UHFFFAOYSA-N |
1,2-Proplenediamine - Physico-chemical Properties
| Molecular Formula | C3H10N2 |
| Molar Mass | 74.12 |
| Density | 0.87g/mLat 25°C(lit.) |
| Melting Point | -37 °C |
| Boling Point | 120-122°C(lit.) |
| Flash Point | 92°F |
| Water Solubility | SOLUBLE |
| Solubility | H2O: very soluble |
| Vapor Presure | 14 mm Hg ( 20 °C) |
| Vapor Density | 2.6 (vs air) |
| Appearance | clear liquid |
| Color | Colorless to Almost colorless |
| Merck | 14,7852 |
| BRN | 605274 |
| pKa | 9.82(at 25℃) |
| PH | 12 (100g/l, H2O, 20℃) |
| Storage Condition | Flammables area |
| Stability | Stable. Flammable. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides. |
| Sensitive | Air Sensitive & Hygroscopic |
| Explosive Limit | 2.2-11.1%(V) |
| Refractive Index | n20/D 1.446 |
| Physical and Chemical Properties | Colorless, transparent, viscous liquid, with ammonia odor. It has strong alkalinity and strong hygroscopicity. |
| Use | For organic synthesis, pharmaceutical and synthetic dyes, and used as cellosolve, rubber vulcanization accelerator |
1,2-Proplenediamine - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | R10 - Flammable R21/22 - Harmful in contact with skin and if swallowed. R35 - Causes severe burns R42/43 - May cause sensitization by inhalation and skin contact. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S23 - Do not breathe vapour. |
| UN IDs | UN 2258 8/PG 2 |
| WGK Germany | 1 |
| RTECS | TX6650000 |
| FLUKA BRAND F CODES | 3-10-23 |
| TSCA | Yes |
| HS Code | 29212900 |
| Hazard Class | 8 |
| Packing Group | II |
1,2-Proplenediamine - Nature
Open Data Verified Data
colorless transparent viscous liquid, ammonia odor. It has strong alkalinity and strong hygroscopicity, and produces white smoke in contact with air. Soluble in water, ethanol and chloroform, insoluble in ether and benzene. The relative density was 0.8584. Boiling point 120.5 °c. Flash point 71.1 °c. Refractive index 4460.
Last Update：2024-01-02 23:10:35
1,2-Proplenediamine - Preparation Method
Open Data Verified Data
obtained by amination of 1,2-chloropropane with liquid ammonia. 1, 2-chloropropane and 25% ammonia water were respectively added to the reactor, so that the temperature was controlled at about 1 50 ° C. And the pressure was maintained at 2. 45MPA, the reaction is carried out, and then the reaction solution is deammoniated, and then neutralized to alkaline with sodium hydroxide. After concentration, desalting, rectification is carried out, and the fraction above 11 2 ℃ is cut out to be the finished product, the yield can reach 65% ~ 70%.
Last Update：2022-01-01 10:35:35
1,2-Proplenediamine - Use
Open Data Verified Data
This product is used for the production of mineral processing agent, metal passivator, aviation resin curing agent, rubber vulcanization accelerator, also used in dyes, electroplating and Analytical reagents.
Last Update：2022-01-01 10:35:34
1,2-Proplenediamine - Safety
Open Data Verified Data
- This product has the same toxicity as ethylenediamine, and has a stimulating effect on skin and mucosa. Long-term exposure can cause Cough, bronchiectasis, nasal bleeding, Head Pain and dizziness and other symptoms. Inhalation of high concentrations of propylenediamine vapor can cause wheezing and fatal poisoning. Protective equipment should be worn during operation to prevent direct contact. Production equipment should be closed, to prevent running, run, drip, leakage, the workplace should be maintained in good ventilation, pay attention to safety.
- the container is packed in an iron drum, and the type of fire is strictly prohibited during storage and transportation.
Last Update：2022-01-01 10:35:36
1,2-Proplenediamine - Reference Information
| LogP | -1.2 at 20℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | used in organic synthesis, pharmacy and synthetic dyes, and used as cellosolve, rubber vulcanization accelerator, etc. used as analytical reagent, cellosolve and rubber vulcanization accelerator used in the production of mineral processing agent, metal passivator, resin curing agent for void, rubber vulcanization accelerator, it is also used for dyes, electroplating and Analytical reagents (mercury, copper and silver assays). It is used in the pharmaceutical industry for the production of 1, 2-propanediamine tetraacetic acid as an intermediate for the anticancer drug propanimine. used in medicine, emulsifier, antioxidant, rubber curing agent, etc. Analytical reagents for mercury, copper and silver. Organic Synthesis. |
| production method | is obtained by ammoniating 1, 2-dichloropropane with liquid ammonia. 1, 2-dichloropropane and 25% aqueous ammonia were separately added to the reactor, and the temperature was controlled at about 150 ° C. And the pressure was maintained at 2.45MPa. After completion of the ammoniation reaction, the reaction solution is deammoniated, neutralized to alkali by adding sodium hydroxide, concentrated, desalted and subjected to rectification, and the fraction above 112 ° C. Is cut out to be the finished product with a yield of 65-70%. Fixed consumption of raw materials: 1, 2-dichloropropane (60%)8000kg/t, liquid ammonia (95%)3000kg/t, sodium hydroxide (40%) 100000kg/t. |
| category | corrosive article |
| toxicity grade | poisoning |
| Acute toxicity | oral-rat LD50: 2230 mg/kg; Abdominal injection-mouse LD50: 593 mg/kg |
| stimulation data | Skin-rabbit 435 mg severe; Eye-rabbit 87 mg severe |
| explosive hazard characteristics | corrosive to skin and cornea |
| flammability hazard characteristics | flammable in case of open or high heat; Thermal decomposition of toxic nitrogen oxide gas |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored separately from acids and oxidants. |
| extinguishing agent | Sand, foam, carbon dioxide, dry powder |
| autoignition temperature | 680 ° F. |
Last Update：2024-04-09 15:16:52
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