1,2-dithio-glycero
2,3-Dimercapto-1-propanol
CAS: 59-52-9
Molecular Formula: C3H8OS2
1,2-dithio-glycero - Names and Identifiers
| Name | 2,3-Dimercapto-1-propanol |
| Synonyms | BAL Dimercaprol Dimercaptol 1,2-DITHIOGLYCEROL 1,2-dithio-glycero dimercaprolpropanol 2,3-Dimercaptopropanol 1,2-Dimercaptopropanol 1,2-Dimercapto-3-propanol 2,3-Dimercapto-1-propanol 1-Propanol, 2,3-dimercapto- 3-hydroxy-1,2-propanedithiol (2S)-2,3-disulfanylpropan-1-ol (2R)-2,3-disulfanylpropan-1-ol |
| CAS | 59-52-9 |
| EINECS | 200-433-7 |
| InChI | InChI=1/C3H8OS2/c4-1-3(6)2-5/h3-6H,1-2H2/t3-/m1/s1 |
1,2-dithio-glycero - Physico-chemical Properties
| Molecular Formula | C3H8OS2 |
| Molar Mass | 124.22 |
| Density | 1.239g/mLat 25°C(lit.) |
| Melting Point | 77 °C |
| Boling Point | 120°C15mm Hg(lit.) |
| Flash Point | >230°F |
| Water Solubility | 87 g/L (25 ºC) |
| Solubility | 87g/l (slow decomposition) |
| Vapor Presure | 7.4 hPa (100 °C) |
| Vapor Density | 4.3 |
| Appearance | Liquid |
| Color | Clear colorless to slightly yellow |
| Odor | pungent odor |
| Merck | 14,3209 |
| BRN | 1732058 |
| pKa | 9.00±0.25(Predicted) |
| PH | 5.0-6.5 (H2O, 20℃)(saturated solution) |
| Storage Condition | Store at +2°C to +8°C. |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents, many metals. |
| Sensitive | Air Sensitive |
| Refractive Index | n20/D 1.573(lit.) |
| Physical and Chemical Properties | Density 1.239 boiling point 120 ° C. (15 mmHg) refractive index 1.57-1.574 water-soluble 87g/L (25°C) |
| Use | As an antidote, suitable for arsenic, mercury, bismuth, gold, cadmium, antimony and other heavy metal ion poisoning |
1,2-dithio-glycero - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R36/38 - Irritating to eyes and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S24/25 - Avoid contact with skin and eyes. S23 - Do not breathe vapour. |
| UN IDs | UN 2810 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | UB2625000 |
| FLUKA BRAND F CODES | 8-9-13-23 |
| TSCA | Yes |
| HS Code | 29309070 |
| Hazard Class | 6.1 |
| Packing Group | III |
| Toxicity | LD50 i.m. in rats: 86.7 mg/kg (Zvirblis, Ellin) |
1,2-dithio-glycero - Standard
Authoritative Data Verified Data
This product is 2, 3-dimercapto-1-propanol. The content of C3HsOS2 shall not be less than 98.5%(g/g).
Last Update：2024-01-02 23:10:35
1,2-dithio-glycero - Trait
Authoritative Data Verified Data
- This product is colorless or almost colorless, easy to flow of the clear liquid; Similar to the garlic special odor.
- This product is very soluble in methanol, ethanol or benzyl benzoate, dissolved in water; Insoluble in fatty oil, but dissolved in benzyl benzoate, can be diluted and mixed with fatty oil.
relative density
The relative density of this product (General rule 0601) is 1.235~1.255 at 25°C.
Last Update：2022-01-01 11:30:12
1,2-dithio-glycero - Differential diagnosis
Authoritative Data Verified Data
- take 1 drop of this product, add 2ml of water to dissolve, add several drops of lead acetate solution, and generate yellow precipitate.
- take a small amount of this product, add sodium carbonate and heat, that is, the occurrence of acrolein special odor.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 15).
Last Update：2022-01-01 11:30:12
1,2-dithio-glycero - Exam
Authoritative Data Verified Data
stability
take this product, after heating for 2 hours at 140C, and determine it according to the method under the content determination item, the loss content shall not exceed 4.0%.
acidity
take l.Og of this product, add 10ml of water, shake to make saturated, filter, and determine according to law (General rule 0631), the pH value should be 5.0~7.0.
bromine
Take 40mg of this product, according to oxygen flask combustion method (General rule 0703) for organic destruction, 2.0% sodium hydroxide solution 15ml and concentrated hydrogen peroxide solution 15 drops as absorption liquid, once the generated smoke is completely absorbed into the absorbing liquid, rinse the bottle stopper with 20ml of water and the platinum wire, combine the washing liquid with the absorbing liquid, heat and boil for 2 minutes, cool, and move into a 50ml Nessler's colorimetric tube, after neutralization with nitric acid solution (1-2), add 2ml more, add 1.0mL of silver nitrate test solution and an appropriate amount of water to 50ml, shake well, and place in the dark for 10 minutes, if turbidity occurs, and the control liquid [same method as the test sample, but not containing the test sample during combustion, and add standard sodium bromide solution (precision weighing sodium bromide 12.88mg, add water 1000ml made, equivalent to 10ug of Br per 1 ml) 4.0ml] should not be more concentrated (0.10%).
Last Update：2022-01-01 11:30:13
1,2-dithio-glycero - Content determination
Authoritative Data Verified Data
take this product about 0.lg, precision weighing, add 10ml ethanol, shake, titration with Iodine titration solution (0.05mol/L) until the solution continues to be yellowish, the results of the titration were corrected by a blank test. Each 1 ml Iodine titration solution (0.05mOl/L) is equivalent to 6.211mg of CaHsOS.
Last Update：2022-01-01 11:30:14
1,2-dithio-glycero - Category
Authoritative Data Verified Data
antidote.
Last Update：2022-01-01 11:30:14
1,2-dithio-glycero - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:30:14
1,2-dithio-glycero - Dimercaptopropanol injection
Authoritative Data Verified Data
- This product is a sterile oil solution of dimercaptopropanol. Dimercaptopropanol (c3h8os2) shall be present in an amount of 95.0% to 105.0% of the label amount.
- This product is added with an appropriate amount of benzyl benzoate as a cosolvent.
trait
This product is colorless to light yellow clear oily liquid.
identification
take 0.3ml of this product, Add 10ml of water, shake, add a few drops of lead acetate test solution, that is, the formation of yellow precipitate.
examination
acidity: take 10ml of this product, add 10ml of water, shake for 2 minutes, let stand for stratification, filter the water layer with neutral filter paper, and measure it according to law (General rule 0631). The pH value should be 4.5~6.5.
Bacterial endotoxin this product, according to the inspection (General 1143), each 1 mg of dimercaptopropanol containing endotoxin should be less than 1.0EU.
Others should comply with the relevant provisions under injections (General rule 0102).
Content determination
take 1 ml of this product with a volume pipette, put it in an Erlenmeyer flask, wash the inner wall of the pipette with anhydrous ethanol-chloroform (3:l)10ml fractional washing, wash solution into the Erlenmeyer flask, add 40ml of anhydrous ethanol-chloroform (3:1), shake well, and titrate with Iodine titration solution (0.05mol/l) until the solution continues to be yellowish, the results of the titration were corrected by a blank test. Each 1 ml of Iodine titration solution (0.05mol/L) is equivalent to 6. 1L mg of c3h8os2.
category
Same as dimercaptopropanol.
specification
(l)lml:0.lg (2)2ml:0.2g
storage
light shielding, closed storage.
Last Update：2022-01-01 11:30:15
1,2-dithio-glycero - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| introduction | dimercaptopropanol is a colorless or almost colorless, easy-to-flow clear liquid. It smells like onion and garlic. It is easily soluble in methanol, ethanol or benzyl benzoate, soluble in water, and insoluble in fatty oil, which can prevent arsenic, mercury, bismuth, gold, antimony and other metals from poisoning body tissues. |
| Biological activity | Dimercaprol (2,3-Dimercapto-1-propanol) is an antidote to heavy metal poisoning and has anti-HIV activity. |
| target | HIV |
| use | this product is an antidote, mainly used for detoxification of arsenic or mercury-containing poisons, and can also be used for poisoning of certain heavy metals (such as bismuth, antimony, cadmium, etc.). 2, 3-dimercaptopropanol reacts with Lewis gas to generate stable, insoluble and non-toxic arsenic compounds. So it is called the British anti-Lewis gas agent. A variety similar to the detoxification effect of dimercaptopropanol is sodium dimercaptosuccinate (C4H4Na2O4S2). This is a new antidote created by our country. Its detoxification effect is stronger than that of dimercaptopropanol and its toxicity is less. The LD50 of dimercaptopropanol injected under the skin of rats was 86.7 mg/kg. As an antidote, it is suitable for poisoning by heavy metal ions such as arsenic, mercury, bismuth, gold, cadmium, and antimony |
| production method | is obtained by addition and meridization of allyl alcohol. |
| category | toxic substances |
| toxicity classification | highly toxic |
| acute toxicity | abdominal cavity-rat LD50: 105 mg/kg; Oral administration-mouse LD50: 217 mg/kg |
| flammability hazard characteristics | flammability; combustion produces toxic sulfur oxide smoke; side effects used by patients; bleeding, dermatitis, skin redness and swelling |
| storage and transportation characteristics | ventilation and low temperature drying; separate from warehouse food |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, mist water |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 15:16:46
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