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1,3-Diazine

Pyrimidine

CAS: 289-95-2;25247-63-6

Molecular Formula: C4H4N2

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1,3-Diazine - Names and Identifiers

Name Pyrimidine
Synonyms Miazine
m-Diazine
NSC 89305
Pyrimidine
1,3-Diazine
Metadiazine
1,3-Diazabenzene
CAS 289-95-2
25247-63-6
EINECS 206-026-0
InChI InChI=1/C4H4N2/c1-2-5-4-6-3-1/h1-4H

1,3-Diazine - Physico-chemical Properties

Molecular FormulaC4H4N2
Molar Mass80.09
Density1.055g/cm3
Melting Point20-22℃
Boling Point122.4°C at 760 mmHg
Flash Point31.1°C
Water Solubilitysoluble
Vapor Presure16.8mmHg at 25°C
AppearanceForm Liquid, color Clear colorless to orange
pKa1.23(at 20℃)
Storage ConditionFlammables area
StabilityStable, but air-sensitive and hygroscopic. Incompatible with acids, acid chlorides, acid anhydrides, strong oxidizing agents, carbon dioxide. Flammable.
SensitiveEasily absorbing moisture
Refractive Index1.503
MDLMFCD00006059
Physical and Chemical Properties

Melting Point: 19-22°C

Boiling Point: 123-124°C

density: 1.016g/mL at 25°C

UseUsed as raw materials for pharmaceutical intermediates, photosensitizers, etc

1,3-Diazine - Risk and Safety

Risk CodesR10 - Flammable
Safety DescriptionS16 - Keep away from sources of ignition.
S23 - Do not breathe vapour.
S24/25 - Avoid contact with skin and eyes.
UN IDsUN 1993
WGK Germany3
RTECSUV6263000
TSCAYes
HS Code29335990
Hazard Class3
Packing GroupIII

1,3-Diazine - Upstream Downstream Industry

Raw MaterialsP-XYLENE-D10
Downstream Products4-Aminopyrimidine
PYRIMIDIN-4-YL-METHANOL

1,3-Diazine - Introduction

Soluble in water, ethanol and ether
Last Update：2022-10-16 17:24:17

1,3-Diazine - Nature

solubility soluble
sensitivity Hygroscopic
Merck 14,7987
BRN 103894
NIST chemical information 1,3-Diazine(289-95-2)
EPA chemical information Pyrimidine (289-95-2)
Last Update：2024-04-09 01:59:50

1,3-Diazine - Uses and synthesis methods

pyrimidine base

One of the chemical components of pyrimidine base nucleotides is composed of carbon, nitrogen, hydrogen, oxygen and other elements. Pyrimidine bases include uracil, cytosine and thymine, where uracil and cytosine constitute the bases in the ribonucleic acid molecule, and thymine and cytosine constitute the bases in the deoxyribonucleic acid molecule. Pyrimidine base has strong absorption effect on ultraviolet light wave with wavelength of 250 ~ 280nm. The raw materials for its synthesis are derived from carbamoyl phosphate and aspartic acid. Pyrimidine base can also be metabolized and decomposed into carbon dioxide, β alanine and β aminoisobutyric acid. Some patients due to congenital factors or taking certain drugs, can cause pyrimidine metabolism disorders, causing whorky aciduria.

fluorouracil

Fluorouracil is a pyrimidine antimetabolite. In vivo, it is first converted to 5-fluoro-2-deoxyuracil nucleotide (FUdRP), inhibits deoxythymidylate synthase (TMPS), prevents deoxyuracil nucleotide from being converted into thymine nucleotide, and interferes with DNA synthesis, leading to cell damage and death. The effect is stronger in the presence of aldehyde hydrofolate (CF), because FUdRP, FH4 and TMPS can form a triple complex, which makes the active metabolite of the drug more tightly bound to the enzyme, so the effect of adding CF when using fluorouracil is better, especially when used in colorectal cancer. This product is a cell cycle specific drug, which has a killing effect on all stages of proliferating cells, is the most sensitive to the S phase, and has a delaying effect on the G1/S boundary. Oral absorption is incomplete, and the drug is easy to inactivate in liver metabolism, and the blood drug concentration is relatively stable after intravenous drip or arterial perfusion.

fluorouracil has a significant effect on choriocarcinoma and malignant hydatidiform mole. It also has certain effects on gastric cancer, colon cancer, rectal cancer, esophageal cancer, liver cancer, pancreatic cancer, breast cancer, ovarian cancer, cervical cancer, prostate cancer, bladder cancer, kidney cancer, lung cancer, head and neck cancer, skin cancer, etc.

The role of purine, pyrimidine and other substances

Purines and pyrimidine are heterocyclic nitrogen-containing compounds necessary for nucleic acid metabolism in organisms (including humans). They are important substances that constitute ribonucleic acid and deoxyribonucleic acid in cells. Purines and pyrimidine combine with ribose and phosphate to form RNA; purines and pyrimidine combine with deoxyribose and phosphate to produce DNA. DNA is the main chemical component of genes, which plays an important role in gene transmission, that is, genetic function. The main role of RNA is to regulate the synthesis of proteins in cells. The final product of purine metabolism is mainly uric acid. Barley and malt contain 0.2% ~ 0.3% nucleic acid dry matter. During saccharification, they are degraded by various phosphatase enzymes to form a variety of degradation products such as nucleotides, nucleosides, purines and pyrimidines. Among them, only purines and pyrimidine enter Yeast cells constitute ribonucleic acid, deoxyribonucleic acid, adenosine triphosphate and certain coenzymes. Nucleotides are difficult to be absorbed. If the culture medium lacks purine and pyrimidine, it has to rely on carbohydrates and amino acids to synthesize, which will consume a lot of energy and affect the proliferation of yeast. Generally speaking, there is no shortage of purines and pyrimidines in wort.

Last Update：2024-04-09 20:52:54
1,3-Diazine
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Nantong Reform Petro-Chemical CO., LTD.
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CAS: 289-95-2
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Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
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Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: Pyrimidine Request for quotation
CAS: 289-95-2
Tel: +86-17551318830
Email: r@reformchem.com­
Mobile: +86-17551318830
QQ: 3785839865 Click to send a QQ messageSend QQ message
Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: Pyrimidine Request for quotation
CAS: 289-95-2
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Pyrimidine Request for quotation
CAS: 289-95-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: Pyrimidine Visit Supplier Webpage Request for quotation
CAS: 289-95-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
View History
1,3-Diazine
Raw Materials for 1,3-Diazine
P-XYLENE-D10
Downstream Products for 1,3-Diazine
4-Aminopyrimidine
PYRIMIDIN-4-YL-METHANOL
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