1,3-difluoropropan-2-one
1,3-difluoro-2-propanol
CAS: 453-13-4
Molecular Formula: C3H6F2O
1,3-difluoropropan-2-one - Names and Identifiers
| Name | 1,3-difluoro-2-propanol |
| Synonyms | Geiftor 1,3-difluoro-2-propano 1,3-DIFLUORO-2-PROPANOL 1,3-DIFLUOROPROPAN-2-OL 1,3-difluoro-2-propanol 1,3-difluoropropan-2-one 2-Propanol, 1,3-difluoro- 1,3-DIFLUORO-ISO-PROPANOL 1,3-Difluoro-2-hydroxypropane |
| CAS | 453-13-4 |
| EINECS | 207-216-6 |
| InChI | InChI=1/C3H4F2O/c4-1-3(6)2-5/h1-2H2 |
1,3-difluoropropan-2-one - Physico-chemical Properties
| Molecular Formula | C3H6F2O |
| Molar Mass | 96.08 |
| Density | 1.24g/mLat 25°C(lit.) |
| Boling Point | 54-55°C34mm Hg(lit.) |
| Flash Point | 108°F |
| Vapor Presure | 68.5mmHg at 25°C |
| Appearance | Liquid |
| Color | Clear yellow to brownish |
| BRN | 1732050 |
| pKa | 12.67±0.20(Predicted) |
| Storage Condition | Flammables area |
| Refractive Index | n20/D 1.373(lit.) |
| Physical and Chemical Properties | Colorless or yellowish transparent liquid, slightly sour. B. P. 120~130 deg C, the relative density of 1.25~1.27 (23 deg C), wherein A compound accounted for 70%, B. p. 127~128 C, relative density 1.244 (20 C), refractive index 1.3800 (20 C);B compound accounted for 30%, B. p. 146 to 148 ° C., the relative density is 1.300 (20 ° C.), and the refractive index is 1.4360 (20 ° C.). Soluble in water, ethanol, ether and other organic solvents, chemical stability in acidic solution, in alkaline solution can be decomposed, high temperature volatile loss of toxicity. |
1,3-difluoropropan-2-one - Risk and Safety
| Risk Codes | R10 - Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | UN 1987 3/PG 3 |
| WGK Germany | 3 |
| RTECS | UB1770000 |
| TSCA | Y |
| HS Code | 29055998 |
| Hazard Note | Flammable |
| Hazard Class | 3 |
| Packing Group | III |
1,3-difluoropropan-2-one - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| toxicity | acute oral LD50 for brown rabbits is 30.0 mg/kg(LD5035mg/kg ), 3.38 mg/kg for dauri pika, 4.5 mg/kg for prairie chinchilla, 10.0 mg/kg for long-scratched gerbils, 2.8 mg/kg for Chinese zokor and 4.0 mg/kg for guinea pigs. It is safer for poultry, chicken LD501500mg/kg, duck 2000 mg/kg. High toxicity to livestock. Ames test, micronucleus test of mouse bone marrow cells and chromosome aberration test of mouse testicular cells were all negative and had no obvious accumulation. |
| use | highly toxic, fast-acting fluorohydrin rodenticide. It is mainly used for rodent control in the wild, especially in grassland pastoral areas. It can be absorbed through the skin and can cause poisoning and death in mice through digestive system, respiratory system or skin contact. The usage content is 0.6%. When it is used for rodent control in houses, warehouses, ships, etc., poison bait is put into rat holes (beside) or places where rats often move. Each room puts 4 piles, each pile is 5-10g, and each hole is 10g during rodent control in the field. Dead rats can be seen 24 hours after administration, with a peak of 2-4 days, and rodent infestation is controlled after 4 days. Mainly used for rodent control in the wild, especially suitable for grassland pastoral areas. With a liquid medicine containing 0.05-0.2% active ingredients, 30g per mu, pikas and other pests can be killed; To prevent and control Apodemus aspodii, hamster and other pests, 0.5, 1.5% bait, 10 × 5 square meters put in a pile, each pile of 10g; Prepare barley bait containing 0.5% active ingredients and put it into rodents for better effect. |
| production method | chloromethyl ethylene oxide and potassium difluoride are reacted in diethylene glycol at 160-170 ℃, and the obtained crude product is distilled under reduced pressure and then distilled under regular pressure to obtain. Raw material consumption quota: 1700kg/t of chloromethyl ethylene oxide, 1000kg/t of potassium difluoride and 1920kg/t of diethylene glycol. using diethylene glycol as solvent, heat and reflux the mixture of epichlorohydrin and hydrogen fluoride-potassium fluoride at 118 ℃. After the reaction, the rat is distilled under reduced pressure to obtain Ganfu. Or epichlorohydrin and KHF2 in diethylene glycol in 160~170 DEG C reaction, by decompression and atmospheric distillation to produce rat Ganvolt. |
| category | pesticide |
| toxicity classification | highly toxic |
| acute toxicity | intravenous injection-mouse LD50: 178 mg/kg |
| flammability hazard characteristics | thermal decomposition of toxic fluoride gas |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; separate from food raw materials storage and transportation |
| fire extinguishing agent | sand, dry powder, foam |
Last Update：2024-04-09 21:11:58
