1,3-二甲基2-氨基苯-1,3-二羧酸酯

1,3-二甲基2-氨基苯-1,3-二羧酸酯 - Names and Identifiers

Name	diMethyl 2-aMinoisophthalate
Synonyms	diMethyl 2-aMinoisophthalate Dimethyl 2-aminoisophthalic acid dimethyl 2-aminobenzene-1,3-dioate dimethyl 2-aminobenzene-1,3-dicarboxylate 1,3-dimethyl 2-aminobenzene-1,3-dicarboxylate 1,3-Benzenedicarboxylic acid, 2-amino-, dimethyl ester 1,3-Benzenedicarboxylic acid, 2-amino-, 1,3-dimethyl ester
CAS	57053-02-8

1,3-二甲基2-氨基苯-1,3-二羧酸酯 - Physico-chemical Properties

Molecular Formula	C10H11NO4
Molar Mass	209.2
Density	1.248±0.06 g/cm3(Predicted)
Melting Point	102-103 °C
Boling Point	309.3±22.0 °C(Predicted)
pKa	-0.19±0.10(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature
Use	Uses Dimethyl 2-aminoiso-phthalate can be used as an intermediate in pharmaceutical and chemical synthesis, such as the preparation of dimethyl 2-(methylsulfonyl amino) isophthalate,

1,3-二甲基2-氨基苯-1,3-二羧酸酯 - Reference Information

preparation

dimethyl 2-amino iso-phthalate is prepared as follows: trimethylsilyldiazane (9.12mL,18.24mmol)(2M in ether) is slowly added to 2-amino -3-(methoxycarbonyl) benzoic acid (2.0g,10.25mmol) in an anhydrous solution of 9mL tetrahydrofuran and 6mL methanol, and then the mixture was stirred overnight at room temperature. The reaction mixture was concentrated and purified by rapid chromatography (1-6% methanol/CH2Cl2) to give the title compound dimethyl 2-aminoiso-phthalate.

use

dimethyl 2-aminoisophthalate can be used as an intermediate in pharmaceutical and chemical synthesis, for example, it can be used to prepare dimethyl 2-(methylsulfonamido) isophthalate,

Last Update：2024-04-10 22:29:15

1,3-二甲基2-氨基苯-1,3-二羧酸酯 - Preparation

Dimethyl 2-aminoiso-phthalate is prepared as follows: Trimethylsilyldiazane (9.12mL,18.24mmol)(2M in diethyl ether) is slowly added to 2-Amino -3-(methoxycarbonyl) benzoic acid (2.0g,10.25mmol) in an anhydrous solution of 9mL tetrahydrofuran and 6mL methanol, and then the mixture is stirred overnight at room temperature. The reaction mixture was concentrated and purified by rapid chromatography (1-6% methanol/CH2Cl2) to give the title compound dimethyl 2-aminoiso-phthalate.

Last Update：2024-04-10 22:29:15