1,4-BIS(TRICHLOROMETHYL)BENZENE

1,4-BIS(TRICHLOROMETHYL)BENZENE - Names and Identifiers

Name	1,4-BIS(TRICHLOROMETHYL)BENZENE
Synonyms	P303 1,4-Di(trichloromethyl)benzene 1,4-BIS(TRICHLOROMETHYL)BENZENE 1,4-bis(trichloromethyl)-benzen A,A,A,A,A,A-HEXACHLORO-P-XYLENE antischistosomiasis preparatiion 846 ALPHA,ALPHA,ALPHA,ALPHA,ALPHA,ALPHA-HEXACHLORO-P-XYLENE
CAS	68-36-0
EINECS	200-686-3

1,4-BIS(TRICHLOROMETHYL)BENZENE - Physico-chemical Properties

Molecular Formula	C8H4Cl6
Molar Mass	312.84
Density	1.6957 (rough estimate)
Melting Point	106-110 °C
Boling Point	312 °C
Appearance	Morphological Crystalline Powder and Chunks, color Light yellow
Storage Condition	Room Temprature
Refractive Index	1.5840 (estimate)
MDL	MFCD00000791
Physical and Chemical Properties	Chemical properties White needle crystal or crystalline powder, made of special odor, tasteless. Melting point 108-110 ℃. Insoluble in water, easily soluble in ethanol, xylene, petroleum ether and vegetable oil. When exposed to light and alkali, acid will be formed.
Use	Widely used in pharmaceutical, pesticide, paint, dye production

1,4-BIS(TRICHLOROMETHYL)BENZENE - Risk and Safety

Hazard Symbols	C - Corrosive
Risk Codes	34 - Causes burns
Safety Description	S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RTECS	ZE4655000
HS Code	29036990

1,4-BIS(TRICHLOROMETHYL)BENZENE - Upstream Downstream Industry

Raw Materials	Xylene Benzoyl peroxide Triethanolamine Activated carbon,decolor m-Xylene P-XYLENE
Downstream Products	1,4-Bis(trifluoromethyl)-benzene

1,4-BIS(TRICHLOROMETHYL)BENZENE - Uses and synthesis methods

use

1. As an anti-schistosomiasis drug, it is effective for liver fluke disease, amoebic disease, malaria and intestinal protozoa in animals.

2. Anti-schistosomiasis drugs. It has certain curative effect on liver fluke disease, amoebic disease, malaria and intestinal nematode. However, adverse reactions to the nervous system are more common, and the delayed reaction lasts for a long time.

production method

1. using mixed xylene as raw material, sulfonate with 98% sulfuric acid first to make m-xylene generate m-xylene sulfonate. The oil layer containing o-and p-xylene is separated from the sulfonated reactant, washed and dried, and distilled o-and p-xylene under reduced pressure. The by-product m-xylene can be obtained by hydrolysis of m-xylene sulfonate. Chlorination of o-and p-xylene yields 1, 4-bis (trichloromethyl) benzene: put o-and p-xylene in the reaction pot, and then add benzoyl peroxide and triethanolamine. After heating to 70 ℃, chlorine gas is introduced under light irradiation, reacted at 70-80 ℃ for 6 hours, and then heated to 100-120 ℃ to continue the reaction until the relative density of the reaction liquid phase reaches 1.560-1.580(65 ℃), which is the end point of the reaction. Chlorine is stopped and residual chlorine is removed under reduced pressure. Cool down to 5 ℃, filter, wash the crude, recrystallize, and decolorize the finished product with activated carbon.

2. It is obtained by chlorination with o-or p-xylene as raw material.

add benzoyl peroxide and triethanolamine to o-or p-xylene, and react with chlorine at 70-80 ℃ for 6h. Then the temperature is raised to 100-120 ℃, and the chlorine gas reaction is continued until the relative density of the feed liquid reaches 1.560-1.580(65 ℃). After the reaction is over, the residual chlorine gas is removed under reduced pressure, cooled to 5 ℃, filtered, washed, decolorized, and recrystallized to obtain the finished product.

Last Update：2024-04-10 22:29:15

1,4-BIS(TRICHLOROMETHYL)BENZENE - Nature

Merck	1303
EPA chemical information	p-Di(trichloromethyl)benzene (68-36-0)

Last Update：2024-04-10 22:29:15

1,4-BIS(TRICHLOROMETHYL)BENZENE - Security information

toxic substance data

68-36-0(Hazardous Substances Data)

Last Update：2024-04-10 22:29:15

Shanghai Macklin Biochemical Co., Ltd

Featured ProductsSpot supply

Product Name: α,α,α,α',α',α'-Hexachloro-p-xylene Visit Supplier Webpage Request for quotation
CAS: 68-36-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328

WhatsApp: +86-18821248368

MedChemExpress (MCE)

Spot supply

Product Name: 1,4-Bis(trichloromethyl)benzene; Chloxyle Visit Supplier Webpage Request for quotation
CAS: 68-36-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
　　　　 tech@medchemexpress.com
Mobile: 609-228-6898