1,4-Bis-(difluoromet

1,4-Bis-(difluoromet - Names and Identifiers

Name	1,4-Bis(difluoromethyl)benzene
Synonyms	1,4-Bis-(difluoromet 1,4-Bis(difluoromethyl)benzene 1,4-BIS(DIFLUOROMETHYL)BENZENE a,a,a',a'-Tetrafluoro-p-xylene 1,4-Bis-(difluoromethyl)benzene 3-[(trifluoromethyl)sulfanyl]aniline ALPHA,ALPHA,ALPHA',ALPHA'-TETRAFLUORO-P-XYLENE 1,4-Bis(difluoromethyl)benzene p-Xylylene alpha,alpha,alpha',alpha'-Tetrafluoride
CAS	369-54-0
EINECS	1312995-182-4
InChI	InChI=1/C7H6F3NS/c8-7(9,10)12-6-3-1-2-5(11)4-6/h1-4H,11H2

1,4-Bis-(difluoromet - Physico-chemical Properties

Molecular Formula	C8H6F4
Molar Mass	178.13
Density	1,312 g/cm3
Boling Point	83-84°C 30mm
Flash Point	63°C
Vapor Presure	1.09mmHg at 25°C
Storage Condition	Sealed in dry,2-8°C
Refractive Index	1.437-1.439
MDL	MFCD01320708

1,4-Bis-(difluoromet - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R10 - Flammable
Safety Description	S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S16 - Keep away from sources of ignition.
HS Code	29039990
Hazard Note	Irritant
Packing Group	III

1,4-Bis-(difluoromet - Introduction

1,4-Bis(difluoromethyl)benzene is an organic compound with the chemical formula C8H6F4. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: colorless liquid
-Melting point:-25°C
-Boiling point: 181°C
-Density: 1.324g/cm³
-Solubility: Soluble in organic solvents, such as alcohols and ethers, insoluble in water.

Use:
1,4-Bis(difluoromethyl)benzene has certain application value in organic synthesis and drug research, and is commonly used for the following purposes:
-As a drug intermediate: used to synthesize drugs and biologically active compounds.
-as a phosphorus-based reagent: participate in organic synthesis reactions, such as olefin phosphorus-based, aromatic hydrocarbon phosphorus-based, etc.

Preparation Method:
1,4-Bis(difluoromethyl)benzene can be synthesized by the following methods:
-Through the substitution reaction: the phenyloctanoic acid is reacted with chloroform and phosphorus trichloride to obtain 1,4-bis (trichloromethyl) benzene, and then reacted with sulfur tetrafluoride to obtain 1,4-Bis(difluoromethyl)benzene.

Safety Information:
The safe use of 1,4-Bis(difluoromethyl)benzene requires attention to the following:
-Irritating to eyes, skin and respiratory system. Wear appropriate protective equipment during operation.
-Avoid contact and inhalation, and operate in a well-ventilated place.
-Store sealed, protected from light, insulated, and stored separately from oxidants and strong acids.
-Laboratory safety practices should be followed during use.

Last Update：2024-04-09 19:05:49