1,4-DI-BOC-2-(HYDROXYMETHYL)PIPERAZINE
Di-tert-butyl 2-(hydroxymethyl)-piperazine-1,4-dicarboxylate
CAS: 143540-05-0
Molecular Formula: C15H28N2O5
1,4-DI-BOC-2-(HYDROXYMETHYL)PIPERAZINE - Names and Identifiers
1,4-DI-BOC-2-(HYDROXYMETHYL)PIPERAZINE - Physico-chemical Properties
| Molecular Formula | C15H28N2O5 |
| Molar Mass | 316.39 |
| Density | 1.123 |
| Melting Point | 119-126°C |
| Boling Point | 406.9±20.0 °C(Predicted) |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 14.97±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Sensitive | IRRITANT |
| MDL | MFCD09908093 |
1,4-DI-BOC-2-(HYDROXYMETHYL)PIPERAZINE - Introduction
Di-tert-butyl 2-(hydroxymethyl)-piperazine-1,4-dicarboxylate is an organic compound with the formula C14H26N2O5.
Nature:
1. Appearance: colorless or yellowish solid.
2. melting point: about 58-62 ℃.
3. Solubility: Soluble in alcohols and organic solvents, slightly soluble in water.
Use:
1. pharmaceutical field: as a synthesis of certain drug intermediates.
2. Organic synthesis: as a blocking agent, it plays a role in controlling and regulating the reaction speed.
3. Chemical research: In the field of organic reactions and organic synthesis, it is often used to construct compounds containing piperazine groups.
Preparation Method:
Di-tert-butyl 2-(hydroxymethyl)-piperazine-1,4-dicarboxylate can be prepared by the following steps:
1. First, 2-benzyloxyformaldehyde is condensed with tert-butylamine to obtain 2-(hydroxymethyl) piperazine di-tert-butyl alcohol.
2. Then, 2-(hydroxymethyl) piperazine di-tert-butyl alcohol is reacted with dimethoxymethacrylic anhydride to produce the Di-tert-butyl 2-(hydroxymethyl)-piperazine-1,4-dicarboxylate.
Safety Information:
Di-tert-butyl 2-(hydroxymethyl)-piperazine-1,4-dicarboxylate has no obvious safety risk under normal operating conditions. However, as a chemical substance, it should comply with laboratory safety practices and avoid inhalation, ingestion or contact with skin. Waste needs to be stored, treated and disposed of properly. Wear appropriate personal protective equipment such as lab gloves and eye protection during use. Refer to the relevant safety data sheets and operating instructions before use.
Nature:
1. Appearance: colorless or yellowish solid.
2. melting point: about 58-62 ℃.
3. Solubility: Soluble in alcohols and organic solvents, slightly soluble in water.
Use:
1. pharmaceutical field: as a synthesis of certain drug intermediates.
2. Organic synthesis: as a blocking agent, it plays a role in controlling and regulating the reaction speed.
3. Chemical research: In the field of organic reactions and organic synthesis, it is often used to construct compounds containing piperazine groups.
Preparation Method:
Di-tert-butyl 2-(hydroxymethyl)-piperazine-1,4-dicarboxylate can be prepared by the following steps:
1. First, 2-benzyloxyformaldehyde is condensed with tert-butylamine to obtain 2-(hydroxymethyl) piperazine di-tert-butyl alcohol.
2. Then, 2-(hydroxymethyl) piperazine di-tert-butyl alcohol is reacted with dimethoxymethacrylic anhydride to produce the Di-tert-butyl 2-(hydroxymethyl)-piperazine-1,4-dicarboxylate.
Safety Information:
Di-tert-butyl 2-(hydroxymethyl)-piperazine-1,4-dicarboxylate has no obvious safety risk under normal operating conditions. However, as a chemical substance, it should comply with laboratory safety practices and avoid inhalation, ingestion or contact with skin. Waste needs to be stored, treated and disposed of properly. Wear appropriate personal protective equipment such as lab gloves and eye protection during use. Refer to the relevant safety data sheets and operating instructions before use.
Last Update：2024-04-09 21:01:54
