1,4-Naphthalenediol,2-methyl-,diacetate
menadiol di(acetate)
CAS: 573-20-6
Molecular Formula: C15H14O4
1,4-Naphthalenediol,2-methyl-,diacetate - Names and Identifiers
| Name | menadiol di(acetate) |
| Synonyms | Kayvite Pafavit VitavelK Vitamin K4 Prokayvitoral ACETOMENAPHTHONE VitaminKdiacetate MENADIOL DIACETATE Menadiol diacetate menadiol di(acetate) 2-methylnaphthalene-1,4-diyl diacetate 1,4-Naphthalenediol,2-methyl-,diacetate |
| CAS | 573-20-6 |
| EINECS | 209-352-1 |
| InChI | InChI=1/C15H14O4/c1-9-8-14(18-10(2)16)12-6-4-5-7-13(12)15(9)19-11(3)17/h4-8H,1-3H3 |
1,4-Naphthalenediol,2-methyl-,diacetate - Physico-chemical Properties
| Molecular Formula | C15H14O4 |
| Molar Mass | 258.27 |
| Density | 1.2105 (rough estimate) |
| Melting Point | 113 °C |
| Boling Point | 361.52°C (rough estimate) |
| Flash Point | 195.1°C |
| Water Solubility | Insoluble in water |
| Vapor Presure | 2.96E-06mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Almost white |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.4872 (estimate) |
| MDL | MFCD00021469 |
| Use | Used as procoagulant |
1,4-Naphthalenediol,2-methyl-,diacetate - Risk and Safety
| RTECS | QJ5250000 |
1,4-Naphthalenediol,2-methyl-,diacetate - Reference
| Reference Show more | Regulatory effect and mechanism of blueberry pomace fermented by Lactobacillus casei on intestinal barrier function in mice fed with high fat diet [D]. Huazhong Agricultural University, 2020. |
1,4-Naphthalenediol,2-methyl-,diacetate - Reference Information
| Introduction | vitamin K4 is a vitamin drug, mainly applicable to coagulation disorders caused by vitamin K deficiency. Such as intestinal malabsorption caused by vitamin K deficiency. Various causes of obstructive jaundice, chronic ulcerative colitis, chronic pancreatitis and extensive small bowel resection after intestinal absorption function; Long-term use of antibiotics can lead to vitamin K deficiency, broad-spectrum antibiotics or intestinal sterilization drugs can kill or inhibit the bacterial community in the normal intestinal tract, resulting in reduced vitamin synthesis by bacteria in the intestinal tract. |
| pharmacological action | as a coenzyme of carboxylase, vitamin K4 participates in the synthesis of coagulation factors II, VII, IX, X, the glutamic acid residues on these factors must form 9-12 gamma-carboxyglutamate under the action of the liver microsomal enzyme system carboxylase, so that these factors have the ability to bind to Ca2, and linked to the phospholipid surface and regulatory proteins, so that these factors have coagulation activity, resulting in coagulation. If the lack of vitamin K4 or epoxide reduction reaction is blocked (such as by coumarin antagonism), factor II, VII, IX, X synthesis is to stay in the precursor state, the prothrombin time is prolonged, caused bleeding. |
| indication | vitamin K4 can be used for vitamin K deficiency and hypothromboplastin. |
| note | Taking vitamin K4 should be noted: 1, patients with liver function damage, the effect of this product is not obvious, blind dosage can aggravate liver injury. 2, this product is invalid for bleeding caused by heparin. Traumatic bleeding is not necessary to use this product. |
| biological activity | Vitamin K4 is a chemically synthesized Vitamin K that plays an important role in the normal blood coagulation system. |
Last Update：2024-04-09 21:54:55
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