Molecular Formula | C17H22O3 |
Molar Mass | 274.35 |
Density | 1.182±0.06 g/cm3(Predicted) |
Melting Point | 193-196 °C (lit.) |
Boling Point | 449.6±45.0 °C(Predicted) |
Specific Rotation(α) | 20546 +165° (c = 4 in abs ethanol) |
Merck | 13,7625 |
pKa | 4.66±0.40(Predicted) |
Storage Condition | 2-8℃ |
In vitro study | Podocarpic acid anhydride acts as a 1 nM agonist of LXRalpha and beta receptors. It shows over 8-10-fold better activator of LXR receptors compared to one of the natural ligands, 22-(R)-hydroxy cholesterol, in HEK-293 cells. |
In vivo study | Podocarpic acid activates SKN-1 in C. elegans, similar to known Nrf2 activators such as α-lipoic acid (LA). Podocarpic acid- or LA-induced SKN-1 activation also requires TRPodocarpic acid-1: trPodocarpic acid-1 knockdown in glod-4;gst-4p::gfp animals reduces expression of gst-4 to wild-type levels. A and LA supplementation results in a robust Ca 2+ flux, which is significantly reduces when the Ca 2+ -impermeable TRPodocarpic acid-1E1018A channel is present, suggesting that TRPodocarpic acid-1 activation is key for these drugs' function. Finally, Podocarpic acid and LA alleviate the Podocarpic acidthogenic phenotypes of glod-4 animals by reverting the high endogenous MGO and GO to almost wild-type-like levels. |
WGK Germany | 3 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.645 ml | 18.224 ml | 36.448 ml |
5 mM | 0.729 ml | 3.645 ml | 7.29 ml |
10 mM | 0.364 ml | 1.822 ml | 3.645 ml |
5 mM | 0.073 ml | 0.364 ml | 0.729 ml |
biological activity | Podocarpic acid is a natural product that is an activator of TRPA1 and has a variety of effects. |