1,4-anhydro-6-O-hexadecanoyl-D-glucitol
span (R) 40 hlb-value 6.7
CAS: 26266-57-9
Molecular Formula: C22H42O6
1,4-anhydro-6-O-hexadecanoyl-D-glucitol - Names and Identifiers
| Name | span (R) 40 hlb-value 6.7 |
| Synonyms | Span-40 Span?40 Span 40 ARLACEL 40 SPAN NO 40 SPAN(TM) 40 Emulsifier S-40 Sorbitanpalmitat sorbitan palmitate SORBITAN PALMITATE SORBITAN MONOPALMITATE Sorbitan monopalmitate SORBITANE MONOPALMITATE SORBITANMONOPALMITATE,NF span (R) 40 hlb-value 6.7 1,4-anhydro-6-O-hexadecanoyl-D-glucitol [2-[(2R,3S,4R)-3,4-dihydroxytetrahydrofuran-2-yl]-2-hydroxy-ethyl] hexadecanoate |
| CAS | 26266-57-9 |
| EINECS | 247-568-8 |
| InChI | InChI=1/C22H42O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-20(25)27-17-19(24)22-21(26)18(23)16-28-22/h18-19,21-24,26H,2-17H2,1H3/t18-,19+,21+,22+/m0/s1 |
| InChIKey | DOCCLKYMPJSXGB-VCDGYCQFSA-N |
1,4-anhydro-6-O-hexadecanoyl-D-glucitol - Physico-chemical Properties
| Molecular Formula | C22H42O6 |
| Molar Mass | 402.57 |
| Density | 1.0412 (rough estimate) |
| Melting Point | 46-47°C(lit.) |
| Boling Point | 444.68°C (rough estimate) |
| Flash Point | >230°F |
| Water Solubility | Insoluble in water |
| Solubility | Practically insoluble in water, soluble in fatty oils, slightly soluble in alcohol. |
| Vapor Presure | 8.77E-15mmHg at 25°C |
| Appearance | White to yellow powder or crystal |
| Color | White flakes |
| Storage Condition | 贮存于阴凉、干燥处，避免日晒、雨淋；有效贮存期12个月。按一般货物运输。 |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.4593 (estimate) |
| MDL | MFCD00080946 |
| Physical and Chemical Properties | Opalescent to light brown waxy solid, with slightly fatty odor. Melting point 45 °c. Dispersed in hot water, soluble in hot oil. Stable in different pH and electrolyte solutions at room temperature. The HLB value was 6.7. Rat oral LD50>10 g/kg,ADl0 ~ 25 mg/kg(FAO/WHO,1994). |
| Use | Used as emulsifier, lubricant, wetting agent, dispersant, thickener, etc |
| Caution | Has low irritancy. Avoid contact with skin and eyes. If accidentally splashed into the eyes, lift the eyelids and rinse with running water or physiological saline. |
1,4-anhydro-6-O-hexadecanoyl-D-glucitol - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 1 |
| RTECS | WG2932900 |
| HS Code | 29400090 |
1,4-anhydro-6-O-hexadecanoyl-D-glucitol - Upstream Downstream Industry
| Raw Materials | Sorbitol Palmitic acid |
1,4-anhydro-6-O-hexadecanoyl-D-glucitol - Standard
Authoritative Data Verified Data
This product is Sorbitan and single palmitic acid ester mixture, sorbitol dehydration, in alkaline catalyst, and single palmitic acid esterification prepared; alternatively, it can be obtained by direct esterification of sorbitol with monopalmitic acid at 180-280°C.
Last Update：2024-01-02 23:10:35
1,4-anhydro-6-O-hexadecanoyl-D-glucitol - Trait
Authoritative Data Verified Data
- This product is a light yellow waxy solid with slight odor.
- This product is insoluble in anhydrous ethanol or water.
acid value
The acid value of this product (General 0713) is not greater than 8.
saponification value
The saponification value of this product (General rule 0713) is 140~150 (saponification time 1 hour).
hydroxyl value
The Hydroxyl value of this product (General 0713) is 275~305.
iodine value
The iodine value of this product (General 0713) is not more than 10.
peroxide value
The peroxide value of this product (General 0713) is not greater than 5.
Last Update：2022-01-01 11:26:10
1,4-anhydro-6-O-hexadecanoyl-D-glucitol - Differential diagnosis
Authoritative Data Verified Data
take about 2 g of this product, put it in a 250ml flask, add 100ml of ethanol and 3.5g of potassium hydroxide, and mix well. Heat reflux for 2 hours, add about 100ml of water, transfer to 250ml beaker while hot, evaporate on a water bath and continue to add water, continue to evaporate until no ethanol odor, finally heat 100ml of water, slowly Dropwise add sulfuric acid solution (1-2) While it is hot until the litmus paper is neutral, record the consumed volume, continue to Dropwise add sulfuric acid solution (1-2)(about 10% of the above consumed volume), the liquid in the lower layer was clarified by standing. Transfer the above solution to a 10%-ml separatory funnel, extract with n-hexane for 3 times, each time, discard the n-hexane layer, take the aqueous layer solution, and adjust the p H value to 7 with potassium hydroxide solution. 0, water bath evaporation to dryness, residual (if necessary, the residue is triturated) and anhydrous ethanol 150ml, stirred with a glass rod, boiled in water bath for 3 minutes, the above solution was placed in a funnel covered with diatomaceous earth, filtered, the filtrate was evaporated to dryness, and the residue was dissolved with 2M l of methanol. As the test solution t, 33mg and 1 of isosorbide were separately taken, 4-to water sorbitol 25mg and sorbitol 25mg, and methanol 1 ml dissolved as a reference solution. According to the thin layer chromatography (General 0502) test, absorb 2 u1 of each of the above two solutions, respectively point on the same silica gel G thin layer plate, with acetone-glacial acetic acid (50:1) as the developing solvent, expand, take out, dry, spray sulfuric acid solution (1-2) to just wet, immediately heat at 200°C until the spots are clear, cool, immediately check, the position and color of the spots of the test solution should be the same as that of the control solution.
Last Update：2022-01-01 11:26:10
1,4-anhydro-6-O-hexadecanoyl-D-glucitol - Exam
Authoritative Data Verified Data
fatty acids
make up 0.lg of this product, put it in a 25ml Erlenmeyer flask, add 2 m l of sodium hydroxide methanol solution of 0.5mo L/l, shake until dissolved, and heat and reflux for 30 minutes, add 2ml of 14% boron trifluoride methanol solution along the condenser tube, heat and reflux for 30 minutes, add 4 ml of n-heptane along the condenser tube, heat and reflux for 5 minutes, cool, add 10ml of saturated gasification sodium solution, shake for 15 seconds, add saturated sodium chloride solution to the neck of the bottle, mix well, let stand for stratification, take 2ml of the upper layer, wash with water for 3 times, 2ml each time, take the upper layer and dry it with anhydrous sodium sulfate,
Test solution; The following appropriate amount of each fatty acid methyl ester reference substance was accurately weighed, dissolved and diluted with n-heptane to prepare a mixed reference solution (1) containing 9.0 mg of methyl palmitate and 1.0 mg of methyl stearate per 1 ml. Take 1.0ml, put it in a 10ml measuring flask, dilute it to the scale with n-heptane, shake it well, and use it as a mixed control solution (2). According to the gas chromatography (General 0521) test, the capillary column with polyethylene glycol as stationary liquid is used as the chromatographic column, the initial temperature is 170°C, the temperature is raised to 230°C at a rate of 2°C per minute, and the temperature is maintained for 10 minutes, injection Port temperature 250°C, detector temperature 250°C, take mixed reference solution (1 )(2) each lul, respectively injection human gas chromatograph, record chromatogram, mixed reference solution (1) the degree of separation between the methyl palmitate peak and the methyl stearate peak is not less than 1 .8, the number of theoretical plate should not be less than 30000 according to the peak of methyl palmitate; The signal to noise ratio of the minimum fatty acid methyl ester peak in the mixed reference solution (2) should be greater than 5. 1ul of sample solution was taken and injected into human Gas Chromatograph. According to the peak area normalization method, palmitic acid was not less than 92.0%, and hard acid was not more than 6 .0%.
moisture
take this product, according to the moisture determination method (General 0832 first method 1), the water content shall not exceed 1.5%.
ignition residue
The l .O g of this product shall be taken for inspection according to law (General rule 0841), and the remaining residue shall not exceed.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
Last Update：2022-01-01 11:26:11
1,4-anhydro-6-O-hexadecanoyl-D-glucitol - Category
Authoritative Data Verified Data
pharmaceutical excipients, emulsifiers and Defoamers.
Last Update：2022-01-01 11:26:11
1,4-anhydro-6-O-hexadecanoyl-D-glucitol - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 11:26:12
1,4-anhydro-6-O-hexadecanoyl-D-glucitol - Preparation method
Open Data Verified Data
Put the measured amount of sorbitol into the reaction vessel, open the vacuum, and dehydrate at 75-80 ℃ until small bubbles are formed inside the vessel. Melt the measured amount of palmitic acid and press it into dehydrated sorbitol anhydride. Add 50% alkaline solution as a catalyst while stirring, gradually raise the temperature to 190-200 ℃ under reduced pressure, and keep it at 190-200 ℃ for 4 hours. Sample and analyze the acid value. The esterification reaction is completed when the acid value is 7-8mgKOH/g. Let it stand and cool overnight, remove the bottom coking material, add an appropriate amount of hydrogen peroxide for decolorization under stirring, and finally heat up to 80-90 ℃. Stir and shape while hot, and cool the packaging to obtain the finished product.
Last Update：2023-12-22 11:49:50
1,4-anhydro-6-O-hexadecanoyl-D-glucitol - Reference Information
| hydrophilic and hydrophilic balance value (HLB value) | 6.7 |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| identification test | solubility is soluble in ethanol, methanol, ether, ethyl acetate, aniline, toluene, dicylethane, petroleum ether and carbon tetrachloride when the temperature is higher than its melting point; Insoluble in cold water but dispersible in warm water. Measured by 0T-42 method. The freezing point is 45~47 ℃. Measured by conventional methods. After saponification of 100g sample with alkali, about 37g polyols and 65g fatty acids can be obtained. According to the method in "polyoxyethylene (8) stearate (10021). |
| content analysis | is the same as in "sorbitan monolaurate (10042). |
| toxicity | ADI O ~ 25 mg/kg(FAO/WHO,2001). |
| usage limit | GB 2760-2001(g/kg): beverage turbidity agent 0.05 (based on final product); Juice (flavor) beverage 0.5; Moon cake 1.5; Ice cream chocolate layer 2.2; Vegetable protein beverage 6.0. FAO/WHO(1984) margarine 10 g/kg. |
| use | as a non-ionic food emulsifier, used alone or mixed with Twain -60, Twain -65, Twain -80. my country stipulates that it can be used for vegetable protein beverages, with a maximum usage of 6.0 g/kg; the maximum usage in ice cream, chocolate, etc. is 2.2 g/kg; the maximum usage in moon cakes is 1.5 g/kg; in fruit juice (flavor) The maximum usage in type beverages is 0.5g.kg; the usage as a turbidity agent in beverages is 0.05 g/kg (based on the final product). used as gas chromatography stationary liquid used as emulsifier, lubricant, wetting agent, dispersant, thickener, etc. gas chromatography stationary liquid, separation and analysis of oxygen-containing compounds. Nonionic surfactant, water/oil emulsifier, thickener. This product is used as a dispersant for printing ink, a dispersant for emulsification of various oil products, an emulsion stabilizer during emulsion polymerization, an effective additive for textile water-resistant composites, an emulsifier for oil fields, and a treatment agent for near wells. |
| production method | put 1 mol sorbitol into the reaction kettle, dehydrate at 75~80 ℃ under vacuum until the small bubbles are turned up in the kettle. 1 mol of palmitic acid was melted and pressed into dehydrated sorbitan anhydride, 1 kg of 50% lye was added under stirring, gradually heated to 190~200 ℃ under reduced pressure, kept at 190~200 ℃ for 4 h, and the acid value was sampled and analyzed. when the acid value was about 7~8, the esterification reaction was completed. Let it stand and cool overnight, remove the bottom coking material, add an appropriate amount of hydrogen peroxide under stirring to decolorize, and finally raise the temperature to 80~90 ℃, stir and form while hot, and cool the package to obtain the finished product. See sorbitan monostearate (10003) |
Last Update：2024-04-09 02:00:07
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Raw Materials for 1,4-anhydro-6-O-hexadecanoyl-D-glucitol