1-(1-(4-fluorophenyl)-2,5-diMethyl-1H-pyrrol-3-yl)-2-(pyrrolidin-1-yl)ethanone
IU1
CAS: 314245-33-5
Molecular Formula: C18H21FN2O
1-(1-(4-fluorophenyl)-2,5-diMethyl-1H-pyrrol-3-yl)-2-(pyrrolidin-1-yl)ethanone - Names and Identifiers
1-(1-(4-fluorophenyl)-2,5-diMethyl-1H-pyrrol-3-yl)-2-(pyrrolidin-1-yl)ethanone - Physico-chemical Properties
| Molecular Formula | C18H21FN2O |
| Molar Mass | 300.37 |
| Density | 1.16±0.1 g/cm3(Predicted) |
| Boling Point | 437.0±45.0 °C(Predicted) |
| Solubility | DMSO: >10mg/mL |
| Appearance | powder |
| Color | off-white to light brown |
| pKa | 8.20±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| In vitro study | IU1 specifically binds to the active form of usp14. IU1 inhibits USP14 by inhibiting its docking to the proteasome, whereas it inhibits the binding of USP14 to 8 other DUBs, IsoT, UCH37, BAP1, UCH-L1, UCH-L3, USP15, USP2, USP7 had little or no inhibitory activity. USP14 was rapidly inhibited by the addition of IU1 and the inhibition was rapidly reversed after removal. IU1 inhibits usp14-induced chain modification and reduces the electrophoretic mobility of types by Ub-CCNB. IU1 enhances Ub-CCNB degradation of the proteasome in the presence of usp14. In the study of protein toxicity mechanism, IU1 promotes the degeneration of tau and reduces by TDP-43, ATXN3, and glial fibrillary acidic protein (GFAP). |
1-(1-(4-fluorophenyl)-2,5-diMethyl-1H-pyrrol-3-yl)-2-(pyrrolidin-1-yl)ethanone - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 41 - Risk of serious damage to eyes |
| Safety Description | 61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| WGK Germany | 3 |
1-(1-(4-fluorophenyl)-2,5-diMethyl-1H-pyrrol-3-yl)-2-(pyrrolidin-1-yl)ethanone - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.329 ml | 16.646 ml | 33.292 ml |
| 5 mM | 0.666 ml | 3.329 ml | 6.658 ml |
| 10 mM | 0.333 ml | 1.665 ml | 3.329 ml |
| 5 mM | 0.067 ml | 0.333 ml | 0.666 ml |
Last Update：2024-01-02 23:10:35
1-(1-(4-fluorophenyl)-2,5-diMethyl-1H-pyrrol-3-yl)-2-(pyrrolidin-1-yl)ethanone - Reference Information
| biological activity | IU1 is a cell-permeable, reversible proteasome (proteasome) selective inhibitor. when acting on USP14, IC50 is 4.7 μM, and the selectivity when acting on IsoT is 25 times higher. IU1 can induce autophagy. |
| target | TargetValue USP14 (cell-free say) 4.7 μM |
| Target | Value |
| USP14 (cell-free assay) | 4.7 μM |
| in vitro study | IU1 specifically binds to the active form of USP14. IU1 inhibits USP14 by inhibiting its attachment to the proteasome, while 8 other DUBs, IsoT, UCH37, BAP1, UCH-L1, UCH-L3, USP15, USP2, USP7 have little or no inhibitory activity. IU1 was added to quickly inhibit USP14. After removal, the inhibition was quickly reversed. IU1 inhibits USP14-induced chain modification and reduces electrophoretic mobility of Ub-CCNB types. In the presence of USP14, IU1 enhances the Ub-CCNB degradation of the proteasome. In the study of protein toxicity mechanism, IU1 promotes the degradation of tau and reduces TDP-43, ATXN3, and glial fibrillary acidic protein (GFAP). |
Last Update：2024-04-10 22:29:15
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Spot supply
Product Name: IU1 Visit Supplier Webpage Request for quotationCAS: 314245-33-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History
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