1-(1-甲基-1H-吡唑-5-基)乙酮

1-(1-甲基-1H-吡唑-5-基)乙酮 - Names and Identifiers

Name	Ethanone, 1-(1-methyl-1H-pyrazol-5-yl)- (9CI)
Synonyms	5-Acetyl-1-methylpyrazole 1-(1-Methyl-1H-pyrazol-5-yl) 1-(1-Methyl-1H-pyrazol-5-yl)ethanone Ethanone, 1-(1-methyl-1H-pyrazol-5-yl)- Ethanone, 1-(1-methyl-1H-pyrazol-5-yl)- (9CI)
CAS	137890-05-2
InChI	InChI=1/C6H8N2O/c1-5(9)6-3-4-7-8(6)2/h3-4H,1-2H3

1-(1-甲基-1H-吡唑-5-基)乙酮 - Physico-chemical Properties

Molecular Formula	C6H8N2O
Molar Mass	124.14
Density	1.11g/cm³
Boling Point	221°C at 760 mmHg
Flash Point	87.4°C
Vapor Presure	0.11mmHg at 25°C
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.543

1-(1-甲基-1H-吡唑-5-基)乙酮 - Introduction

1-Methyl -5-acetyl -1H-pyrazole (abbreviated MEP) is an organic compound with the formula C8H9NO2. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: MEP is a colorless to light yellow crystalline object.
-Melting point: about 108-110°C.
-Boiling point: about 242-243°C.
-Density: about 1.176g/cm³.
-Solubility: MEP is soluble in some organic solvents (such as alcohols and ketones), but has low solubility in water.

Use:
MEP has a certain importance in organic synthesis, and its uses mainly include:
-As a drug intermediate: MEP is an intermediate for the synthesis of some drugs, such as the antiepileptic drug phenytoin.
-Used in the synthesis of chemical reagents: MEP can be used as a chemical reagent for the synthesis of other organic compounds.

Preparation Method:
A commonly used method for preparing MEP is to react 1-methyl -1H-pyrazole-5-methanone and acetic anhydride as raw materials under alkaline conditions. The specific preparation method is as follows:
1. In absolute ethanol, add an alkaline reagent (such as sodium carbonate or potassium carbonate) solution.
2. 1-Methyl-1H-pyrazole-5-methanone and acetic anhydride are gradually added to the solution and allowed to react at room temperature for a period of time (e. g., several hours).
3. After completion of the reaction, the precipitate was filtered and purified by crystallization to obtain the MEP product.

Safety Information:
As a chemical, safety precautions are required when using and handling MEP:
-operation should wear chemical protective gloves, safety glasses and other personal protective equipment, avoid contact with skin and eyes.
-Operate in a well-ventilated place to avoid inhaling its dust.
-Avoid contact with strong oxidants and strong acids to avoid dangerous reactions.
-For storage, store the MEP in a dry, cool, and sealed container, away from fire and static electricity.

Last Update：2024-04-09 19:05:46