1-(2,3,4,5,6-Pentafluorophenyl)ethanone

1-(2,3,4,5,6-Pentafluorophenyl)ethanone - Names and Identifiers

Name	2',3',4',5',6'-Pentafluoroacetophenone
Synonyms	PENTAFLUOROACETOPHENONE 1-(pentafluorophenyl)ethanone Ethanone, 1-(pentafluorophenyl)- 2,3,4,5,6-PENTAFLUOROACETOPHENONE 2,3,4,5,6-Pentafluoroacetophenone 2',3',4',5',6'-Pentafluoroacetophenone 2',3',4',5',6'-PENTAFLUOROACETOPHENONE 1-(2,3,4,5,6-Pentafluorophenyl)ethanone Acetophenone, 2',3',4',5',6'-pentafluoro-
CAS	652-29-9
EINECS	211-487-6
InChI	InChI=1/C8H3F5O/c1-2(14)3-4(9)6(11)8(13)7(12)5(3)10/h1H3

1-(2,3,4,5,6-Pentafluorophenyl)ethanone - Physico-chemical Properties

Molecular Formula	C8H3F5O
Molar Mass	210.1
Density	1.476g/mLat 25°C(lit.)
Melting Point	130.5 °C
Boling Point	130-131°C(lit.)
Flash Point	150°F
Vapor Presure	9.68mmHg at 25°C
Specific Gravity	1.476
BRN	2053225
Storage Condition	Inert atmosphere,Room Temperature
Refractive Index	n20/D 1.4366(lit.)
MDL	MFCD00000296

1-(2,3,4,5,6-Pentafluorophenyl)ethanone - Risk and Safety

Hazard Symbols	F - Flammable
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	24/25 - Avoid contact with skin and eyes.
WGK Germany	3
HS Code	29147000
Hazard Note	Flammable

1-(2,3,4,5,6-Pentafluorophenyl)ethanone - Introduction

2 ',3',4 ',5',6 '-Pentafluoroacetophenone, also known as 2',3 ',4',5 ',6'-Pentafluoroacetophenone, is an organic compound. The following is a description of the nature, use, preparation and safety information of 2 ',3',4 ',5',6 '-Pentafluoroacetophenone:

Nature:
-Appearance: White solid
-Molecular formula: C8H3F5O
-Molecular weight: 210.10g/mol
-Melting point: 38-41 degrees Celsius
-Boiling point: 133-135 degrees Celsius
-Solubility: Soluble in organic solvents such as methanol and ethanol

Use:
- 2 ',3',4 ',5',6 '-Pentafluoroacetophenone is often used as an important intermediate in drug synthesis. It can be used to synthesize drugs containing fluorine compounds, such as antiambivalent amines and fluoroazoles.
- 2 ',3',4 ',5',6 '-Pentafluoroacetophenone can also be used as a reagent in organic synthesis, for example, as a catalyst in the synthesis of aromatic ketones.

Preparation Method:
- 2 ',3',4 ',5',6 '-Pentafluoroacetophenone are generally prepared by fluorinated acetophenone. A specific step is to react acetophenone with potassium pentafluoride or ammonium pentafluoride to give 2 ',3',4 ',5',6 '-Pentafluoroacetophenone. The reaction conditions are generally carried out under inert gas protection.

Safety Information:
- 2 ',3',4 ',5',6 '-Pentafluoroacetophenone are organic compounds and need to pay attention to safe operation.
-During use or operation, good laboratory practices should be observed, such as wearing appropriate protective equipment (such as gloves and glasses).
- 2 ',3',4 ',5',6 '-Pentafluoroacetophenone are irritating and contact with skin and eyes may cause irritation or burns. Therefore, direct contact and inhalation should be avoided during use.
-During handling and storage, care should be taken to prevent contact with oxidants and high-temperature substances to avoid the risk of fire or explosion.

Please note that the above information is for reference only, and specific experimental operations and safety measures still need to be evaluated and taken according to the actual situation.

Last Update：2024-04-09 20:48:19