1-(2,4-Dihydroxyphenyl)hexan-1-one
4-Hexanoylresorcinol
CAS: 3144-54-5
Molecular Formula: C12H16O3
1-(2,4-Dihydroxyphenyl)hexan-1-one - Names and Identifiers
1-(2,4-Dihydroxyphenyl)hexan-1-one - Physico-chemical Properties
| Molecular Formula | C12H16O3 |
| Molar Mass | 208.25 |
| Density | 1.0989 (rough estimate) |
| Melting Point | 53-56 °C(lit.) |
| Boling Point | 217 °C14 mm Hg(lit.) |
| Flash Point | >230 °F |
| pKa | 7.83±0.35(Predicted) |
| Refractive Index | 1.5141 (estimate) |
| Physical and Chemical Properties | Chemical properties solid. Melting point 53-56 ℃, boiling point 217 ℃(1.87kPa). |
| Use | Uses intermediates in organic synthesis. It is used for the production of anthelmintic drug casostatin. |
1-(2,4-Dihydroxyphenyl)hexan-1-one - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
1-(2,4-Dihydroxyphenyl)hexan-1-one - Production method
It is obtained by the reaction of resorcinol and hexanoic acid. First, 1/2 amount of acid is put into the dissolving pot, anhydrous zinc chloride is added under stirring, heated and stirred to completely dissolve the mixture at about 120 ℃. In addition, the 1/2 acid is put into a condensation pot, resorcinol is added, stirred to heat up and dissolve, the above zinc chloride-acid solution is added dropwise at about 120 ℃, the pressure is reduced to 93.3kPa, the temperature is kept for 3 hours, and the water generated by the reaction is steamed out at the same time. After the reaction is over, reduce the temperature to 80°C, add water to wash 5 times, move to a distillation pot, perform atmospheric dehydration, decompression dehydration, and recover the unreacted acid to obtain the condensation product hexanoylresorcinol.
Last Update：2024-04-09 19:04:55