1-(2-Aminophenyl)-3-(3-nitrophenyl)prop-2-en-1-one
1-(2-Aminophenyl)-3-(3-nitrophenyl)prop-2-en-1-one
CAS: 123134-61-2
Molecular Formula: C15H12N2O3
1-(2-Aminophenyl)-3-(3-nitrophenyl)prop-2-en-1-one - Names and Identifiers
1-(2-Aminophenyl)-3-(3-nitrophenyl)prop-2-en-1-one - Physico-chemical Properties
| Molecular Formula | C15H12N2O3 |
| Molar Mass | 268.27 |
| Density | 1.315±0.06 g/cm3(Predicted) |
| Boling Point | 482.1±45.0 °C(Predicted) |
| pKa | -0.47±0.10(Predicted) |
| Storage Condition | 2-8°C |
1-(2-Aminophenyl)-3-(3-nitrophenyl)prop-2-en-1-one - Reference Information
| biological activity | TMBIM6 angiist -1 is a potential TMBIM6 antagonist that inhibits the binding of TMBIM6 to mTORC2, mTORC2 activity is reduced, regulating the release of Ca2 from tmbmi 6. |
| Cell Line: | HT1080, MCF7, MDA-MB-2341 and SKBR3 cells. WT and TMBIM6 KO HT1080 cells. |
| Concentration: | 0.5-10 μM. 0, 2, 5 μM. |
| Incubation Time: | 3 days. |
| Result: | Inhibited cell viability. Downregulated the protein levels of AKT-pS473. Impaired cell-driven tumor growth. |
| Animal Model: | Six- to eight-week BklNbt:BALB/c/nu/nu old mice (HT1080 and MDA-MB-231 cells). |
| Dosage: | 1 mg/kg. |
| Administration: | IP 5 days per week during 25 days. |
Last Update：2024-04-09 02:00:13
