1-(2-Chlorophenyl)-N-(1-Methylpropyl)-3-Isoquinolinecarboxamide

Name	1-(2-Chlorophenyl)-N-(1-Methylpropyl)-3-Isoquinolinecarboxamide
Synonyms	PK 11195 PK 11195 PERIPHERAL BENZODIAZE 1-(2-chlorophenyl)-N-methyl-*N-(1-methylpropyl)-3 chlorophenylmethyl(1-methylpropyl)isoquinolinecarboxamide 1-(2-Chlorophenyl)-N-(1-methylpropyl)-3-isoquinolinecarboxamide 1-(2-Chlorophenyl)-N-(1-Methylpropyl)-3-Isoquinolinecarboxamide 1-(2-chlorophenyl)-n-methyl-n-(1-methylpropyl)-3-isoquinolinecarboxamid n-methyl-n-(1-methylpropyl)-1-(2-chlorophenyl)isoquinoline-3-carboxamide 1-(2-CHLOROPHENYL)-N-METHYL-N-(1-METHYLPROPYL)-3-ISOQUINOLINECARBOXAMIDE
CAS	85532-75-8

Molecular Formula	C21H21ClN2O
Molar Mass	352.86
Density	1.179±0.06 g/cm3(Predicted)
Boling Point	511.7±45.0 °C(Predicted)
Solubility	Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml).
Appearance	White crystalline powder.
Color	White
pKa	1.76±0.50(Predicted)
Storage Condition	Store at RT
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored under nitrogen or argon at -20° for up to 1 month.
In vitro study	Median IC 50 values for PK 11195 are 14.2 μM for L. amazonensis , 8.2 μM for L. major , and 3.5 μM for L. braziliensis . The selective index value for L. amazonensis is 13.7, indicating the safety of PK 11195 for future testing in mammals. Time-and dose-dependent reductions in the percentage of infected macrophages, the number of parasites per infected macrophage, and the number of viable intracellular parasites are observed. Electron microscopy reveals some morphological alterations suggestive of autophagy. Interestingly, MCP-1 and superoxide levels are reduced in L. amazonensis -infected macrophages treated with PK 11195 [1] .

WGK Germany	3
RTECS	NW6987000

biological activity	PK 11195 (RP 52028) is a ligand of TSPO, which can target leishmaniasis. its IC50 values for l. amazonensis, l. major and l. braziliensis are 14.2 μ m, 8.2 μ m and 3.5 μ m respectively.
target	IC50: 14.2 μM ( L. amazonensis ), 8.2 μM ( L. major ), 3.5 μM ( L. braziliensis ) [1] .
in vitro study	Median IC 50 values for PK 11195 are 14.2 μ m for l. amazonensis , 8.2 μ m for l. major , and 3.5 μ m for l. braziliensis. the selective index value for l. amazonensis is 13.7, indicating the safety of PK 11195 for future testing in mammals. Time-and dose-dependent reductions in the percentage of infected macrophages, the number of parasites per infected macrophage, and the number of viable intracellular parasites are observed. Electron microscopy reveals some morphological alterations suggestive of autophagy. Interestingly, MCP-1 and superoxide levels are reduced in L. amazonensis -infected macrophages treated with PK 11195 [1] .

Last Update：2024-04-09 20:49:11

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