1-(2-Hydroxy-naphthalen-1-yl)-ethanone

1-(2-Hydroxy-naphthalen-1-yl)-ethanone - Names and Identifiers

Name	1-(2-hydroxy-1-naphthyl)ethan-1-one
Synonyms	1-Acetyl-2-naphthol 1-Acetyl-2-naphthalenol 1-Acetylnaphthalen-2-ol 1-Acetyl-2-hydroxynaphthlene 2'-Hydroxy-1'-acetonaphthone 2-Hydroxy-1-acetylnaphthalene 1-Acetyl-2-hydroxynaphthalene 1'-Acetonaphthone, 2'-hydroxy- 1-(2-Hydroxy-1-naphthyl)ethanone 1-Acetonaphthone,2-hydroxy- (4CI) Methyl2-hydroxy-1-naphthyl ketone 2-Hydroxy-1-naphthyl methyl ketone (2-Hydroxynaphthen-1-yl)ethan-1-one 1-(2-hydroxy-1-naphthyl)ethan-1-one 1-(2-Hydroxy-naphthalen-1-yl)-ethanone Ethanone,1-(2-hydroxy-1-naphthalenyl)- 1-(2-Hydroxynaphthalen-1-yl)ethan-1-one 1'-Acetonaphthone, 2'-hydroxy- (6CI,7CI,8CI) 1-Acetyl-2-hydroxynaphthalene1-Acetyl-2-naphthol
CAS	574-19-6
EINECS	209-369-4
InChI	InChI=1/C12H10O2/c1-8(13)12-10-5-3-2-4-9(10)6-7-11(12)14/h2-7,14H,1H3

1-(2-Hydroxy-naphthalen-1-yl)-ethanone - Physico-chemical Properties

Molecular Formula	C12H10O2
Molar Mass	186.21
Density	1.1032 (rough estimate)
Melting Point	65-67°C(lit.)
Boling Point	130-132°C 2mm
Flash Point	130-132°C/2mm
Vapor Presure	6.37E-05mmHg at 25°C
Appearance	powder to crystal
Color	Light yellow to Brown to Dark green
BRN	1869900
pKa	8.12±0.50(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.6010 (estimate)
MDL	MFCD00012131

1-(2-Hydroxy-naphthalen-1-yl)-ethanone - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection
WGK Germany	3
HS Code	29145090
Hazard Note	Irritant

1-(2-Hydroxy-naphthalen-1-yl)-ethanone - Introduction

1-(2-hydroxy-1-naphthyl)ethan-1-one, also known as 1-(2-hydroxy-1-naphthyl) ethanone, has the chemical formula C12H10O2. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
1-(2-hydroxy-1-napthyl) ethan-1-one is a yellow solid. It has a unique aroma, a density of 1.191g/cm3, a melting point of 91-95°C, and a boiling point of 288-290°C. The compound is stable at room temperature and soluble in organic solvents such as ethanol, ether and chloroform.

Use:
1-(2-hydroxy-1-napthyl) ethan-1-one have a variety of applications in chemical research and industry. It is an important fluorescent dye and organic synthesis intermediate, which can be used to synthesize various naphthyl compounds. In addition, it is also used as a pharmaceutical raw material in the field of biomedicine, such as some drugs with fluorescent probe properties.

Preparation Method:
1-(2-hydroxy-1-napthyl) ethan-1-one can be synthesized by the following method:
1.1-naphthalene ethyl ketone is reacted with sodium hypochlorite and caustic potash in ethanol, neutralized by sodium hydroxide, and esterified with acetic anhydride to generate 1-(2-hydroxy-1-napthyl) ethan-1-one.
2.1-naphthalene ethyl ketone and bromine in the presence of potassium carbonate reaction, and then potassium bicarbonate and alcohol aqueous solution treatment, and finally through the acid acetic anhydride esterification reaction.

Safety Information:
1-(2-hydroxy-1-napthyl) ethan-1-one is generally considered to be a low-toxic compound, but appropriate safety measures still need to be taken. Avoid inhaling dust or solution, avoid contact with skin and eyes, and use protective gloves and goggles. Avoid reaction with oxidants, strong acids and strong bases and store them properly. For accidental contact or ingestion, seek medical attention promptly.

Last Update：2024-04-09 02:00:46