Name | 2'-Hydroxyacetophenone |
Synonyms | usafke-20 FEMA 3548 USAF ke-20 AKOS 90575 O-ACETOPHENOL 2-ACETOPHENOL o-Acetyl phenol AKOS BBS-00003239 O-HYDROXYACETOPHENONE 2'-HYDROXYACETOPHENONE 2'-Hydroxyacetophenone 1-(2-Hydroxyphenyl)ethanone 1-(2-hydroxyphenyl)-ethanon o-hydroxyphenylmethylketone 1-(3-hydroxyphenyl)ethanone 2-Hydroxyphenyl methyl ketone 2-HYDROXYPHENYL METHYL KETONE |
CAS | 118-93-4 104809-67-8 |
EINECS | 204-288-0 |
InChI | InChI=1/C8H8O2/c1-6(9)7-4-2-3-5-8(7)10/h2-5,10H,1H3 |
Molecular Formula | C8H8O2 |
Molar Mass | 136.15 |
Density | 1.131g/mLat 25°C(lit.) |
Melting Point | 3-6°C(lit.) |
Boling Point | 213°C717mm Hg(lit.) |
Flash Point | >230°F |
JECFA Number | 727 |
Water Solubility | slightly soluble |
Solubility | 0.2g/l |
Vapor Presure | ~0.2 mm Hg ( 20 °C) |
Vapor Density | 4.7 (vs air) |
Appearance | Liquid |
Color | Clear yellow to brown |
BRN | 386123 |
pKa | 10.06(at 25℃) |
Storage Condition | Store below +30°C. |
Explosive Limit | 0.98-11.8%(V) |
Refractive Index | n20/D 1.558(lit.) |
Physical and Chemical Properties | Density 1.131 melting point 4-6°C Boiling Point 213 ° C (717 mmHg) refractive index 1.558-1.56 flash point 112°C water-soluble easily soluble |
Use | For the synthesis of pharmaceutical intermediates |
Hazard Symbols | Xi - Irritant |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R36/38 - Irritating to eyes and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
WGK Germany | 3 |
RTECS | AM8575000 |
FLUKA BRAND F CODES | 8 |
TSCA | Yes |
HS Code | 29145000 |
Hazard Note | Harmful/Irritant |
Toxicity | LD50 orally in Rabbit: 2127 mg/kg LD50 dermal Rat > 2000 mg/kg |
Downstream Products | Propafenone HCl |
FEMA | 3548 | 2-HYDROXYACETOPHENONE |
LogP | 1.92-1.97 at 25℃ |
dissociation constant | 10.06-10.25 at 20-25 ℃ |
NIST chemical information | information provided by: webbook.nist.gov (external link) |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
toxicity | GRAS(FEMA). |
usage limit | FEMA(mg/kg): baked goods, snack food, 0.2; Meat products, soup, poultry products, flavorings, instant coffee and tea, household spices, 0.1. |
Use | an intermediate of propafenone. O-hydroxyacetophenone is used in the synthesis of pharmaceutical intermediates, such as propafenone. perfume additives used in organic synthesis. |