1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea
SB 225002
CAS: 182498-32-4
Molecular Formula: C13H10BrN3O4
1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea - Names and Identifiers
| Name | SB 225002 |
| Synonyms | SB225002 SB-225002 SB 225002 1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea N-(2-HYDROXY-4-NITROPHENYL)-N'-(2-BROMOPHENYL)UREA N-(2-BROMOPHENYL)-N'-(2-HYDROXY-4-NITROPHENYL)UREA Urea, N-(2-bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)- |
| CAS | 182498-32-4 |
| InChIKey | MQBZVUNNWUIPMK-UHFFFAOYSA-N |
1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea - Physico-chemical Properties
| Molecular Formula | C13H10BrN3O4 |
| Molar Mass | 352.14 |
| Solubility | Soluble to 100mM in DMSO and to 50mM in ethanol |
| Appearance | Yellow solid |
| Color | white to beige |
| Storage Condition | room temp |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| Sensitive | Moisture Sensitive |
| In vitro study | In vitro experiments, SB225002 inhibited groα-stimulated calcium mobilization and effectively inhibited IL-8 and groα-induced chemotaxis of human and rabbit neutrophils. SB 225002 substantially reduced the level of phosphorylated ERK1/2 and reduced cell differentiation in WHCO1 cells. SB225002 also exhibits anti-tumor activity as a microtubule inhibitor. In an in vitro experiment, SB225002 inhibited groα-stimulated calcium mobilization and effectively inhibited IL-8 and groα-induced chemotaxis of human and rabbit neutrophils. SB 225002 substantially reduced the level of phosphorylated ERK1/2 and reduced cell differentiation in WHCO1 cells. SB225002 also exhibits anti-tumor activity as a microtubule inhibitor. |
| In vivo study | In rabbits, SB225002 selectively blocked IL-8-induced neutrophil flanking. SB225002 (1 mg/kg I. p.) inhibits the growth of subcutaneously implanted tumors in a mouse intrahepatic cholangiocarcinoma model. In addition, SB225002 also exhibited a long-acting anti-inflammatory effect and reduced TNBS-induced colitis in a mouse model. In rabbits, SB225002 selectively blocked IL-8-induced neutrophil flanking. SB225002 (1 mg/kg I. p.) inhibits the growth of subcutaneously implanted tumors in a mouse intrahepatic cholangiocarcinoma model. In addition, SB225002 also exhibited a long-acting anti-inflammatory effect and reduced TNBS-induced colitis in a mouse model. |
1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.84 ml | 14.199 ml | 28.398 ml |
| 5 mM | 0.568 ml | 2.84 ml | 5.68 ml |
| 10 mM | 0.284 ml | 1.42 ml | 2.84 ml |
| 5 mM | 0.057 ml | 0.284 ml | 0.568 ml |
Last Update：2024-01-02 23:10:35
1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea - Reference Information
| biological activity | SB225002 is a potent and selective CXCR2 antagonist that inhibits the binding of interleukin IL-8 to CXCR2, the IC50 was 22 nM and the selectivity was more than 150-fold higher than the other 7-TMRs tested. SB225002 is a potent and selective CXCR2 antagonist that inhibits the binding of interleukin IL-8 to CXCR2 with an IC50 of 22 nM and is more than 150-fold more selective than the other 7-TMRs tested. |
| in vitro study | in vitro experiment, SB225002 inhibits calcium mobilization stimulated by GRO Alpha, and effectively inhibit the chemotaxis of human and rabbit neutrophils induced by IL-8 and groα. SB 225002 substantially reduced the level of phosphorylated ERK1/2 and reduced cell differentiation in WHCO1 cells. SB225002 also exhibits anti-tumor activity as a microtubule inhibitor. In an in vitro experiment, SB225002 inhibited groα-stimulated calcium mobilization and effectively inhibited IL-8 and groα-induced chemotaxis of human and rabbit neutrophils. SB 225002 substantially reduced the level of phosphorylated ERK1/2 and reduced cell differentiation in WHCO1 cells. SB225002 also exhibits anti-tumor activity as a microtubule inhibitor. |
| in vivo study | in rabbits, SB225002 selectively blocked IL-8-induced flanking of neutrophils. SB225002 (1 mg/kg I. p.) inhibits the growth of subcutaneously implanted tumors in a mouse intrahepatic cholangiocarcinoma model. In addition, SB225002 also exhibited a long-acting anti-inflammatory effect and reduced TNBS-induced colitis in a mouse model. In rabbits, SB225002 selectively blocked IL-8-induced neutrophil flanking. SB225002 (1 mg/kg I. p.) inhibits the growth of subcutaneously implanted tumors in a mouse intrahepatic cholangiocarcinoma model. In addition, SB225002 also exhibited a long-acting anti-inflammatory effect and reduced TNBS-induced colitis in a mouse model. |
| Target | TargetValue CXCR2 (Cell-free assay) 22 nM |
| Target | Value |
| CXCR2 (Cell-free assay) | 22 nM |
Last Update：2024-04-10 22:29:15
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CAS: 182498-32-4
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Product Name: SB-225002 Request for quotation
CAS: 182498-32-4
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
CAS: 182498-32-4
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: SB 225002 Visit Supplier Webpage Request for quotationCAS: 182498-32-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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