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1-(2-deoxypentofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione

(+)-5-Iodo-2'-deoxyuridine

CAS: 54-42-2

Molecular Formula: C9H11IN2O5

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1-(2-deoxypentofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione - Names and Identifiers

Name (+)-5-Iodo-2'-deoxyuridine
Synonyms IDU
5iudr
5-IUdR
DENDRID
Idoxuridine
5-Iodo-deoxyuridine
2-Deoxy-5-iodouridine
5-Iodo-2'-deoxyuridine
5-Indo-2ˊ-deoxyuridine
2'-deoxy-5-iodo-uridin
5-iodo-2'-deoxy-d-uridine
5-iodouracildeoxyriboside
(+)-5-Iodo-2'-deoxyuridine
5-Iodouracil deoxyriboside
1beta-D-2'-Deoxyribofuranosyl-5-iodouracil
1-beta-d-2'-deoxyribofuranosyl-5-iodouracil
1-(2-deoxypentofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione
1-(2-deoxy-beta-D-threo-pentofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione
1-[(3xi)-2-deoxy-beta-D-glycero-pentofuranosyl]-5-iodopyrimidine-2,4(1H,3H)-dione
CAS 54-42-2
EINECS 200-207-8
InChI InChI=1/C9H11IN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7?/m0/s1
InChIKey XQFRJNBWHJMXHO-FSDSQADBSA-N

1-(2-deoxypentofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione - Physico-chemical Properties

Molecular FormulaC9H11IN2O5
Molar Mass354.1
Density1.7911 (estimate)
Melting Point194 °C (lit.)
Specific Rotation(α)280 º (c=1,1M NaOH)
Water Solubility1.6 g/L (20 ºC)
Solubility DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated), Water (Sligh
AppearanceWhite crystal
ColorWhite to slightly beige
Merck14,4891
BRN30397
pKa8.25(at 25℃)
Storage Condition2-8°C
SensitiveAir & Light Sensitive
Refractive Index30 ° (C=1, 1mol/L Na
MDLMFCD00134656
Physical and Chemical PropertiesThis product is white crystalline powder. Slightly soluble in water, methanol, ethanol or acetone, almost insoluble in chloroform or ether; Soluble in sodium hydroxide solution, slightly soluble in dilute hydrochloric acid. mp 176-184 °c (decomposition).
UseA cytotoxic analog of thymidine, antiviral

1-(2-deoxypentofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione - Risk and Safety

Risk CodesR45 - May cause cancer
R46 - May cause heritable genetic damage
R61 - May cause harm to the unborn child
R40 - Limited evidence of a carcinogenic effect
R68 - Possible risk of irreversible effects
R62 - Possible risk of impaired fertility
R36/37/38 - Irritating to eyes, respiratory system and skin.
R63 - Possible risk of harm to the unborn child
Safety DescriptionS53 - Avoid exposure - obtain special instructions before use.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36 - Wear suitable protective clothing.
S22 - Do not breathe dust.
S36/37 - Wear suitable protective clothing and gloves.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany3
RTECSYU7700000
FLUKA BRAND F CODES8-23
TSCAYes
HS Code29389090
ToxicityLD50 i.p. in mice: 2.5 g/kg (Prusoff, 1979)

1-(2-deoxypentofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione - Nature

Open Data Verified Data
  • This product is a white crystalline powder. Slightly soluble in water, methanol, ethanol or acetone, almost insoluble in chloroform or ether; Soluble in sodium hydroxide solution, slightly soluble in dilute hydrochloric acid. Melting point 17 6~184 C (decomposition).
  • This product can compete with Virus thymidine for phosphorylase and polymerase, so that Virus of the ability to synthesize deoxyribonucleic acid is inhibited, stop breeding or lose activity. In ophthalmology, it is mainly used to treat superficial herpes simplex keratitis, herpes zoster ophthalmicus and vaccine virus infectious diseases.
Last Update：2024-01-02 23:10:35

1-(2-deoxypentofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione - Use

Open Data Verified Data

antiviral drugs.

Last Update：2022-01-01 11:12:39

1-(2-deoxypentofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione - Safety

Open Data Verified Data

light shielding, closed storage.

Last Update：2022-01-01 11:12:39

1-(2-deoxypentofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione - Reference Information

NIST chemical information Information provided by: webbook.nist.gov (external link)
EPA chemical information Information provided by: ofmpub.epa.gov (external link)
biological activity Idoxuridine (NSC 39661, SKF 14287) is an antiviral drug that acts on a feline herpes virus type 1 with an IC50 of 4.3 μM.
TargetValue
Feline herpesvirus type-1(FHV-1) 4.3 μM
use antiviral drugs. Used for herpetic keratitis and other herpetic eye diseases. Long-term application may appear corneal opacities or staining dots, not easy to disappear. Pregnant women are banned.
Antiviral drugs are used for herpes simplex keratitis and herpes encephalitis.
production methods there are many production methods. Starting from propargyl alcohol, after oxidation, esterification, and cyclization with 2-aminooxazoline nucleoside, 2,2-oxopyrimidine nucleoside can be obtained, and then acylation, bromination, catalytic hydrogenation, and hydrolysis Get iodide. 5 '-deoxycytosine nucleotides can be prepared from fish essence, and iodide can also be prepared after further processing.
toxic substance data information provided by: pubchem.ncbi.nlm.nih.gov (external link)
Last Update：2024-04-09 19:05:12
1-(2-deoxypentofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione
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Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: (+)-5-Iodo-2'-deoxyuridine Request for quotation
CAS: 54-42-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: 5-IDU Visit Supplier Webpage Request for quotation
CAS: 54-42-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Shanghai Worldyang Chemical Co.,Ltd.
Product Name: 5--Iodo-2'-deoxyuridine Request for quotation
CAS: 54-42-2
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228 Click to send a QQ message
Wechat: 13651600618
WhatsApp: +8613651600618
Zouping Mingxing Chemical Co., Ltd.
Product Name: Iodoside Request for quotation
CAS: 54-42-2
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987 Click to send a QQ message
Wechat: 13605431940
WhatsApp: 13605431940
Hangzhou Verychem Science And Technology Co.Ltd
Multiple Specifications
Product Name: 5-Iodo-2'-Deoxyuridine Request for quotation
CAS: 54-42-2
Tel: +86-571-88162785
Email: Lucy@verypharm.com
Mobile: +86-13606544505
QQ: 472954302 Click to send a QQ message
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1-(2-deoxypentofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione
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