1-(2-hydroxy-4,5-dimethoxyphenyl)ethanone

1-(2-hydroxy-4,5-dimethoxyphenyl)ethanone - Names and Identifiers

Name	2'-hydroxy-4',5'-dimethoxyacetophenone
Synonyms	AURORA KA-3659 4,5-DIMETHOXY-2-HYDROXYACETOPHENONE 4,5-Dimethoxy-2-hydroxyacetophenone 2'-HYDROXY-4',5'-DIMETHOXYACETOPHENONE 4',5'-DIMETHOXY-2'-HYDROXYACETOPHENONE 2'-hydroxy-4',5'-dimethoxyacetophenone 1-(2-hydroxy-4,5-dimethoxyphenyl)ethanone 1-(2-HYDROXY-4,5-DIMETHOXYPHENYL)ETHAN-1-ONE Ethanone, 1-(2-hydroxy-4,5-dimethoxyphenyl)-
CAS	20628-06-2
InChI	InChI=1/C10H12O4/c1-6(11)7-4-9(13-2)10(14-3)5-8(7)12/h4-5,12H,1-3H3

1-(2-hydroxy-4,5-dimethoxyphenyl)ethanone - Physico-chemical Properties

Molecular Formula	C10H12O4
Molar Mass	196.2
Density	1.172±0.06 g/cm3(Predicted)
Melting Point	113-114°C
Boling Point	332.3±37.0 °C(Predicted)
Flash Point	130.6°C
Vapor Presure	7.63E-05mmHg at 25°C
Appearance	powder
Color	White to Light yellow to Light orange
pKa	10.29±0.23(Predicted)
Storage Condition	Room Temprature
Refractive Index	1.527
MDL	MFCD00017241

1-(2-hydroxy-4,5-dimethoxyphenyl)ethanone - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3

1-(2-hydroxy-4,5-dimethoxyphenyl)ethanone - Introduction

2 '-hydroxy-4',5 '-dimethoxyacetophenone, chemical formula C10H12O4, molecular weight of 196.20g/mol. The following is its nature, use, preparation and safety information:

Nature:
2 '-hydroxy-4',5 '-dimethoxyacetophenone is an organic compound with colorless or yellowish crystal appearance. It is stable at room temperature and is not volatile. It has an aromatic odor and can be dissolved in some organic solvents such as ethanol and dimethylformamide.

Use:
2 '-hydroxy-4',5 '-dimethoxyacetophenone is commonly used as a drug intermediate, mainly for the synthesis of anti-inflammatory drugs, analgesic drugs and anti-allergic drugs. Because of its regulatory effect on inflammatory reaction and allergic reaction, it is widely used in the field of medicine.

Method:
2 '-hydroxy-4',5 '-dimethoxyacetophenone has various preparation methods. One commonly used method is the condensation reaction of acetanilide and methyl iodide under alkaline conditions, hydroxymethylation and methoxylation reactions are then carried out to give the target product.

Safety Information:
2 '-hydroxy-4',5 '-dimethoxyacetophenone needs to pay attention to safety protection measures in the use of scientific laboratories. It is irritating and may cause damage to the skin, eyes and respiratory system. Avoid direct contact with skin and eyes, and wear appropriate protective gloves and goggles when necessary. At the same time, the experimental site should be kept well ventilated to avoid inhaling the gas of the compound. Avoid contact with oxidants, acids and high temperatures during storage and handling. For safety reasons, the safe operation manual of the compound should be carefully understood before use, and the handling and storage should be carried out according to relevant regulations.

Last Update：2024-04-09 21:11:58