1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)thiourea
NS-11021
CAS: 956014-19-0
Molecular Formula: C16H9BrF6N6S
1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)thiourea - Names and Identifiers
| Name | NS-11021 |
| Synonyms | NS11021 CS-2184 NS 11021 NS-11021 (3,5-Bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)thiourea 1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)thiourea N′-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-thiourea Thiourea, N'-[3,5-bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]- |
| CAS | 956014-19-0 |
1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)thiourea - Physico-chemical Properties
| Molecular Formula | C16H9BrF6N6S |
| Molar Mass | 511.24 |
| Solubility | DMSO: soluble15mg/mL, clear |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | Sealed in dry,2-8°C |
| Use | NS-11021 is an activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle. NS11021 enhances erectile responses in rats. |
1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)thiourea - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)thiourea - Reference
| Reference Show more | 1: Frankenreiter S, Groneberg D, Kuret A, Krieg T, Ruth P, Friebe A, Lukowski R. Cardioprotection by ischemic postconditioning and cGMP-elevating agents involves cardiomyocyte nitric oxide-sensitive guanylyl cyclase. Cardiovasc Res. 2018 Feb 9. doi: 10.1093/cvr/cvy039. [Epub ahead of print] PubMed PMID: 29438488. 2: Zaidman NA, Panoskaltsis-Mortari A, O'Grady SM. Large-conductance Ca(2+) -activated K(+) channel activation by apical P2Y receptor agonists requires hydrocortisone in differentiated airway epithelium. J Physiol. 2017 Jul 15;595(14):4631-4645. doi: 10.1113/JP274200. Epub 2017 Jun 11. PubMed PMID: 28481415; PubMed Central PMCID: PMC5509885. 3: Su F, Guo AC, Li WW, Zhao YL, Qu ZY, Wang YJ, Wang Q, Zhu YL. Low-Dose Ethanol Preconditioning Protects Against Oxygen-Glucose Deprivation/Reoxygenation-Induced Neuronal Injury By Activating Large Conductance, Ca(2+)-Activated K(+) Channels In Vitro. Neurosci Bull. 2017 Feb;33(1):28-40. doi: 10.1007/s12264-016-0080-3. Epub 2016 Nov 16. PubMed PMID: 27854008; PubMed Central PMCID: PMC5567547. 4: Zhong XZ, Sun X, Cao Q, Dong G, Schiffmann R, Dong XP. BK channel agonist represents a potential therapeutic approach for lysosomal storage diseases. Sci Rep. 2016 Sep 27;6:33684. doi: 10.1038/srep33684. PubMed PMID: 27670435; PubMed Central PMCID: PMC5037385. |
1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)thiourea - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.956 ml | 9.78 ml | 19.56 ml |
| 5 mM | 0.391 ml | 1.956 ml | 3.912 ml |
| 10 mM | 0.196 ml | 0.978 ml | 1.956 ml |
| 5 mM | 0.039 ml | 0.196 ml | 0.391 ml |
Last Update：2024-01-02 23:10:35
1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)thiourea - Reference Information
| biological activity | NS 11021 is a potent and specific activator of Ca2-activated large-conductance K (KCa1.1) channels. At concentrations above 0.3 μm, NS 11021 generates more negative potentials by moving the channel activation curve in parallel, activating KCa1.1 in a concentration-dependent manner. |
| Target | Ca 2 -activated big-conduction K Channels |
Last Update：2024-04-09 21:54:55
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Spot supply
Product Name: NS-11021 Visit Supplier Webpage Request for quotationCAS: 956014-19-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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