1-(3,5-dichloro-2-hydroxyphenyl)ethanone

1-(3,5-dichloro-2-hydroxyphenyl)ethanone - Names and Identifiers

Name	3',5'-dichloro-2'-hydroxyacetophenone
Synonyms	4,6-Dichloro-2-acetylphenol 2-Acetyl-4,6-dichlorophenol 3,5-Dichloro-2-hydroxyacetophenone 3',5'-dichloro-2'-hydroxyacetophenone 2'-Hydroxy-3',5'-dichloroacetophenone 3',5'-DICHLORO-2'-HYDROXYACETOPHENONE Acetophenone, 3',5'-dichloro-2'-hydroxy- 1-(3,5-dichloro-2-hydroxyphenyl)ethanone 1-(3,5-DICHLORO-2-HYDROXYPHENYL)ETHANONE 1-(3,5-DICHLORO-2-HYDROXYPHENYL)ETHAN-1-ONE Ethanone, 1-(3,5-dichloro-2-hydroxyphenyl)-
CAS	3321-92-4
EINECS	628-184-3
InChI	InChI=1/C8H6Cl2O2/c1-4(11)6-2-5(9)3-7(10)8(6)12/h2-3,12H,1H3

1-(3,5-dichloro-2-hydroxyphenyl)ethanone - Physico-chemical Properties

Molecular Formula	C8H6Cl2O2
Molar Mass	205.04
Density	1.3806 (rough estimate)
Melting Point	94-97°C(lit.)
Boling Point	132-134°C18mm Hg(lit.)
Flash Point	132-134°C/18mm
Solubility	soluble in Acetone
Vapor Presure	0.000856mmHg at 25°C
Appearance	powder to crystal
Color	White to Orange to Green
Maximum wavelength(λmax)	['343nm(lit.)']
BRN	1638099
pKa	8.26±0.23(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.5490 (estimate)
MDL	MFCD00016417

1-(3,5-dichloro-2-hydroxyphenyl)ethanone - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3
HS Code	29147000
Hazard Note	Irritant

1-(3,5-dichloro-2-hydroxyphenyl)ethanone - Introduction

3 ',5'-dichloro-2 '-hydroxyacetophenone is an organic compound with the chemical formula C8H6Cl2O2. It is a white solid with a special aroma. The following is a detailed description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: White crystalline solid
-Melting point: 78-80 degrees Celsius
-Boiling point: 335 degrees Celsius
-Density: 1.5g/cm³
-Solubility: Soluble in ethanol, ether, chloroform and benzene and other organic solvents, slightly soluble in water.

Use:
3 ',5'-dichloro-2 '-hydroxyacetophenone has a variety of uses in chemical synthesis, including:
-As an important reagent in scientific research, it is used in organic synthesis reaction.
-In the field of medicine, it is used as a raw material for the synthesis of certain drugs.
-Due to its special aroma, it can also be used for the synthesis of flavors and spices.

Method:
3 ',5'-dichloro-2 '-hydroxyacetophenone can be synthesized by the following steps:
1. Acetophenone is reacted with chlorine in the presence of sodium hydroxide to obtain 2 '-chloroacetophenone.
2.2.2 '-Hydroxyacetophenone is obtained by reacting 2'-chloroacetophenone with ferrous oxide.
3. Finally, on the basis of 2 '-hydroxyacetophenone, chlorine atoms at 3' and 5 'positions are introduced by chlorination reaction to obtain the final product 3',5 '-dichloro-2'-hydroxyacetophenone.

Safety Information:
3 ',5'-dichloro-2 '-hydroxyacetophenone is an organic compound. The following safety precautions should be paid attention to when using it:
-Avoid contact with skin and eyes. Wear appropriate protective gloves, goggles and laboratory coats when using.
-During operation and storage, it is necessary to maintain a well-ventilated environment and avoid inhaling its vapor or dust.
-Avoid contact with strong oxidants and strong acids. Avoid open flames, heat and sparks.
-Do not eat and avoid entering the mouth by mistake. If you accidentally enter, please seek medical attention in time.

Last Update：2024-04-09 21:04:16