1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea
BRM/BRG1 ATP Inhibitor-1
CAS: 2270879-17-7
Molecular Formula: C11H9F3N4O2S
1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea - Names and Identifiers
| Name | BRM/BRG1 ATP Inhibitor-1 |
| Synonyms | 1-(3-(DIFLUOROMETHYL)ISOTHIAZOL-5-YL)-3-(2-FLUORO-5-(HYDROXYMETHYL)PYRIDIN-4-YL)UREA 1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea Urea, N-[3-(difluoromethyl)-5-isothiazolyl]-N'-[2-fluoro-5-(hydroxymethyl)-4-pyridinyl]- |
| CAS | 2270879-17-7 |
1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea - Physico-chemical Properties
| Molecular Formula | C11H9F3N4O2S |
| Molar Mass | 318.27 |
| Density | 1.659±0.06 g/cm3(Predicted) |
| Boling Point | 333.4±42.0 °C(Predicted) |
| Solubility | Soluble in DMSO |
| pKa | 11.76±0.70(Predicted) |
| Storage Condition | -20℃ |
| Use | BRM/BRG1 ATP Inhibitor-1 is an allosteric dual Brahma homolog (BRM)/SWI/SNF related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SMARCA2) and BRG1/SMARCA4 ATPase activity inhibitor (IC50s<0.005 µM). |
| Target | BRM, BRG1 : ic50 ﹤0.005 µM |
1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea - Reference
| Reference Show more | [1]. Papillon JPN, et al. Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. J Med Chem. 2018 Nov 21;61(22):10155-10172 |
1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.142 ml | 15.71 ml | 31.42 ml |
| 5 mM | 0.628 ml | 3.142 ml | 6.284 ml |
| 10 mM | 0.314 ml | 1.571 ml | 3.142 ml |
| 5 mM | 0.063 ml | 0.314 ml | 0.628 ml |
Last Update：2024-01-02 23:10:35
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Product Name: BRM/BRG1 ATP Inhibitor-1 Visit Supplier Webpage Request for quotationCAS: 2270879-17-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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