1-(3-Chlorophenyl)-4,4,4-trifluoro-1,3-butanedione
1-(3-chlorophenyl)-4,4,4-trifluoro-butane-1,3-dione
CAS: 23975-61-3
Molecular Formula: C10H6ClF3O2
1-(3-Chlorophenyl)-4,4,4-trifluoro-1,3-butanedione - Names and Identifiers
| Name | 1-(3-chlorophenyl)-4,4,4-trifluoro-butane-1,3-dione |
| Synonyms | LogP 1-(3-CHLOROPHENYL)-4,4,4-TRIFLUOROBUTANE-1,3-DIONE 1-(3-Chlorophenyl)-4,4,4-trifluoro-1,3-butanedione 1-(3-Chlorophenyl)-4,4,4-trifluorobutane-1,3-dione 1-(3-chlorophenyl)-4,4,4-trifluoro-butane-1,3-dione 1,3-Butanedione, 1-(3-chlorophenyl)-4,4,4-trifluoro- |
| CAS | 23975-61-3 |
| InChI | InChI=1/C10H6ClF3O2/c11-7-3-1-2-6(4-7)8(15)5-9(16)10(12,13)14/h1-4H,5H2 |
1-(3-Chlorophenyl)-4,4,4-trifluoro-1,3-butanedione - Physico-chemical Properties
| Molecular Formula | C10H6ClF3O2 |
| Molar Mass | 250.6 |
| Density | 1.396g/cm3 |
| Boling Point | 105°C/1mm |
| Flash Point | 129.7°C |
| Vapor Presure | 0.00202mmHg at 25°C |
| Refractive Index | 1.479 |
1-(3-Chlorophenyl)-4,4,4-trifluoro-1,3-butanedione - Introduction
1-(3-chlorophenyl)-4,4, 4-trifluororo-butane-1, 3-dione is an organic compound with the chemical formula C10H8ClF3O2. The following is a description of its nature, use, preparation and safety information:
Nature:
1-(3-chlorophenyl)-4,4, 4-trifluororo-butane-1, 3-dione is a colorless crystal or white crystalline powder with a special odor. It has a density of 1.49g/cm³ and a melting point of 87-88 ° C. Stable at room temperature, but may decompose when heated.
Use:
1-(3-chlorophenyl)-4,4,4-trifluoro-butane-1,3-dione is widely used in the field of organic synthesis. It can be used as a reagent in organic synthesis for the synthesis of other organic compounds. It can also be used as an intermediate in the preparation of pesticides, pharmaceuticals and materials science.
Method:
The method for preparing 1-(3-chlorophenyl)-4,4,4-trifluoro-butane-1,3-dione can be carried out through fluorination reaction and ketone synthesis reaction. First, under suitable conditions, 3-chlorobenzoic acid and hydrogen oxide are subjected to fluorination reaction to obtain 3-chlorobenzoic acid fluoride. Then, 3-chlorobenzoic acid fluoride was reacted with butanedione, and the substitution reaction was carried out under suitable conditions to obtain 1-(3-chlorophenyl)-4,4, 4-trifluororo-butane-1, 3-dione.
Safety Information:
1-(3-chlorophenyl)-4,4, 4-trifluororo-butane-1, 3-dione produces toxic smoke and corrosive gases when heated, so inhalation and swallowing should be avoided. Wear protective glasses and gloves during operation to ensure good ventilation. During storage and handling, it needs to be stored separately from flammable substances, oxidants and other substances. If the skin or eyes are exposed, rinse immediately with plenty of water for at least 15 minutes and seek medical help.
Nature:
1-(3-chlorophenyl)-4,4, 4-trifluororo-butane-1, 3-dione is a colorless crystal or white crystalline powder with a special odor. It has a density of 1.49g/cm³ and a melting point of 87-88 ° C. Stable at room temperature, but may decompose when heated.
Use:
1-(3-chlorophenyl)-4,4,4-trifluoro-butane-1,3-dione is widely used in the field of organic synthesis. It can be used as a reagent in organic synthesis for the synthesis of other organic compounds. It can also be used as an intermediate in the preparation of pesticides, pharmaceuticals and materials science.
Method:
The method for preparing 1-(3-chlorophenyl)-4,4,4-trifluoro-butane-1,3-dione can be carried out through fluorination reaction and ketone synthesis reaction. First, under suitable conditions, 3-chlorobenzoic acid and hydrogen oxide are subjected to fluorination reaction to obtain 3-chlorobenzoic acid fluoride. Then, 3-chlorobenzoic acid fluoride was reacted with butanedione, and the substitution reaction was carried out under suitable conditions to obtain 1-(3-chlorophenyl)-4,4, 4-trifluororo-butane-1, 3-dione.
Safety Information:
1-(3-chlorophenyl)-4,4, 4-trifluororo-butane-1, 3-dione produces toxic smoke and corrosive gases when heated, so inhalation and swallowing should be avoided. Wear protective glasses and gloves during operation to ensure good ventilation. During storage and handling, it needs to be stored separately from flammable substances, oxidants and other substances. If the skin or eyes are exposed, rinse immediately with plenty of water for at least 15 minutes and seek medical help.
Last Update：2024-04-09 21:01:54
