1-(3-fluoro-4-methoxyphenyl)cyclopropane-1-carbonitrile - Names and Identifiers
1-(3-fluoro-4-methoxyphenyl)cyclopropane-1-carbonitrile - Physico-chemical Properties
1-(3-fluoro-4-methoxyphenyl)cyclopropane-1-carbonitrile - Introduction
1-(3-fluoro-4-methoxyphenyl)cyclopropane-1-carbonitrile is an organic compound with the molecular formula C11H9FNO. Its properties are as follows:
Appearance: Colorless to yellowish solid
Melting point: 97-100 ° C
Boiling point: 276-278 ° C
Density: 1.25g/cm³
1-(3-fluoro-4-methoxyphenyl)cyclopropane-1-carbonitrile is an important organic synthesis intermediate with a wide range of applications. Its Main uses include:
1. For the synthesis of drugs and pesticide intermediates.
2. In the field of medicine, it can be used for synthetic steroid hormones, β-receptor blockers and other drugs.
3. In the field of pesticides, can be used for synthetic pesticides, herbicides and other pesticides.
The method of preparing 1-(3-fluoro-4-methoxyphenyl)cyclopropane-1-carbonitrile is generally carried out by the following steps:
1. Reaction of 3-fluoro-4-methoxyacetophenone and hydrocyanic acid with a base yields 1-(3-fluoro-4-methoxyphenyl)-2-buten-1-one.
2. The reaction of 1-(3-fluoro-4-methoxyphenyl)-2-buten-1-one with ethyl bromoacetate and triisopropylboron fluoride yields 1-(3-fluoro-4-methoxyphenyl)cyclopropane-1-carbonitrile.
Regarding safety information, 1-(3-fluoro-4-methoxyphenyl)cyclopropane-1-carbonitrile needs to pay attention to the following matters when handling and storing:
1. Avoid contact with oxidants and strong acids to avoid dangerous reactions.
2. Avoid inhalation, contact with skin and eyes. In case of accidental contact, rinse immediately with plenty of water and seek medical help.
3. Operate in a well-ventilated area and wear appropriate protective equipment, such as gloves, protective glasses and masks.
4. In storage should avoid high temperature and fire.
Please note that when handling and using chemicals, you should follow relevant safety operations and carefully read the safety data sheet (SDS) of the chemical.
Last Update：2024-04-09 19:05:55