1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydroisochinolin-6,7-diol

Name	1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol
Synonyms	Norcoclaurine Demethyl-Coclaurine Demethyl coclaurine 1-(4-Hydroxybenzyl) Higenamine - natural DL-Demethylcoclaurine 1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydroisochinolin-6,7-diol 1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol 1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol Isoquinolin-6,7-diol, 1,2,3,4-tetrahydro-1-[4-hydroxybenzyl]- 1-[(4-hydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol 1,2,3,4-Tetrahydro-1-[(4-hydroxyphenyl)methyl]-6,7-isoquinolinediol 6,7-isoquinolinediol, 1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]- 6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-((4-hydroxyphenyl)methyl)-, (+-)-
CAS	5843-65-2
InChI	InChI=1/C16H17NO3/c18-12-3-1-10(2-4-12)7-14-13-9-16(20)15(19)8-11(13)5-6-17-14/h1-4,8-9,14,17-20H,5-7H2

Molecular Formula	C16H17NO3
Molar Mass	271.31
Density	1.317±0.06 g/cm3(Predicted)
Melting Point	208-210 °C
Boling Point	522.4±50.0 °C(Predicted)
Flash Point	209.6°C
Solubility	DMSO (Slightly), Methanol (Slightly)
Vapor Presure	1.56E-11mmHg at 25°C
Appearance	Solid
Color	White to Off-White
pKa	9.72±0.40(Predicted)
Storage Condition	Refrigerator
Refractive Index	1.666

Overview	noraconitine, also known as demethylhengzhou aconitine, is an antiarrhythmic drug. This product is the active ingredient of aconite, can enhance myocardial contractility, speed up the heart rate; Dilate the heart, brain and surrounding blood vessels; Improve the role of chronic arrhythmia. It is clinically used for the treatment of chronic arrhythmia and sick sinus syndrome.
biological activity	Demethyl-Coclaurine (Higenamine, norcorourine) is a key component of Aconitum root, it is an agonist of beta-2 adreneric receptor (β2-AR). Demethyl-Coclaurine can stimulate the phosphorylation of AKT, and the activation of PI3K is required for the anti apoptotic effect of myocardial cells.
Target	Value
category	toxic substances
toxicity grade	poisoning
Acute toxicity	oral-mouse LD50: 3350 mg/kg; Intraperitoneal-mouse LD50: 300 mg/kg
flammability hazard characteristics	flammable; Thermal decomposition of toxic nitrogen oxide gases
storage and transportation characteristics	warehouse low temperature, ventilation, dry
extinguishing agent	water, carbon dioxide, dry powder, sand

Last Update：2024-04-09 02:00:09

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1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydroisochinolin-6,7-diol Request for Quotation