Name | 4-Methoxychalcone |
Synonyms | 4-Methoxychalcone 4'-METHOXYCHALCONE RARECHEM AM UC 0609 METHOXYCHALCONE, 4'- alpha-styryl p-anisyl ketone 2-BENZYLIDENE-4'-METHOXYACETOPHENONE 1-(4-METHOXYPHENYL)-3-PHENYLPROP-2-EN-1-ONE (E)-1-(4-METHOXYPHENYL)-3-PHENYLPROP-2-EN-1-ONE |
CAS | 959-23-9 |
EINECS | 213-495-5 |
Molecular Formula | C16H14O2 |
Molar Mass | 238.28 |
Density | 1.114±0.06 g/cm3(Predicted) |
Melting Point | 101-103°C(lit.) |
Boling Point | 397.5±42.0 °C(Predicted) |
Water Solubility | Soluble in dichloromethane and methanol. Insoluble in water. |
Solubility | Soluble in dichloromethane and methanol. Insoluble in water. |
BRN | 644640 |
Storage Condition | 2-8℃ |
Sensitive | Avoid oxide contact |
MDL | MFCD00008407 |
In vitro study | 4'-Methoxychalcone (5 μM; 8 days) markedly increases the mRNA expression of adipogenic genes during adipocyte differentiation, PPARγ, aP2, FAS, adiponectin and GluT 4. 4'-Methoxychalcone (5 μM; 8 days) reduces the upregulated mRNA expression of IL-6, PAI-1, and MCP-1 by TNF-α in preadipocyte 3T3-L1 cells. 4'-Methoxychalcone (5 μM; 0-8 days) causes an increase in PPARγ expression during differentiation, while C/EBPβ protein expression is relatively unaffected. RT-PCR Cell Line: Preadipocyte 3T3-L1 cells Concentration: 5 μM Incubation Time: 0 day; 2 days; 4 days; 6 days; 8 days Result: Increased the mRNA expression of all adipogenic genes, except GluT1 in adipocyte. Western Blot Analysis Cell Line: Preadipocyte 3T3-L1 cells Concentration: 5 μM Incubation Time: 8 days Result: Increased PPARγ expression in adipocyte. |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
WGK Germany | 3 |
biological activity | 4 '-Methoxychalcone exists in citrus plants and is a chalcone derivative with a variety of pharmacological activities, such as anti-tumor and anti-inflammatory activities. |
target | PPARγ |
in vitro research | 4 '-Methoxychalcone (5 μM; 8 days) markedly increases the mRNA expression of adipogenic genes duration adipocyte differentiation, PPARγ, aP2, FAS, adiponectin and GluT 4.4'-Methoxychalcone (5 μ M; 8 days) reduces the upregulated mRNA expression of IL-6, PAI-1, and MCP-1 by TNF-α in preadipocyte 3T3-L1 cells. 4 '-Methoxychalcone (5 μ M; 0-8 days) causes an increase in PPARγ expression duration differentiation, while C/EBPβ protein expression is relatively unaffected. RT-PCR Cell Line: Preadipocyte 3T3-L1 cells Concentration: 5 μM Incubation Time: 0 day; 2 days; 4 days; 6 days; 8 days Result: Increased the mRNA expression of all adipogenic genes, except GluT1 in adipocyte. Western Blot Analysis Cell Line: Preadipocyte 3T3-L1 cells Concentration: 5 μM Incubation Time: 8 days Result: increased PPARγ expression in adipocyte. |
Cell Line: | Preadipocyte 3T3-L1 cells Preadipocyte 3T3-L1 cells |
Concentration: | 5 μM 5 μM |
Incubation Time: | 0 day; 2 days; 4 days; 6 days; 8 days 8 days |
Result: | Increased the mRNA expression of all adipogenic genes, except GluT1 in adipocyte. Increased PPARγ expression in adipocyte. |